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[1] Dasari S, Tchounwou PB. Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol. 2014; 740: 364-378.

[2] Florea A-M, Büsselberg D. Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects. Cancers. 2011; 3(1): 1351-1371.

[3] Rybak LP, Whitworth CA, Mukherjea D, Ramkumar V. Mechanisms of cisplatin-induced ototoxicity and prevention. Hearing Res. 2007; 226(1): 157-167.

[4] Kaplowitz N. Drug-induced liver injury. Clin Infect Dis. 2004;38(Supplement_2): S44-S48.

[5] Waseem M, Bhardwaj M, Tabassum H, Raisuddin S, Parvez S. Cisplatin hepatotoxicity mediated by mitochondrial stress. Drug Chem Toxicol. 2015; 38(4): 452-459.

[6] Huang T-H, Chiu Y-H, Chan Y-L, Wang H, Li T-L, Liu C-Y, Yang C-T, Lee T-Y, You J-S, Hsu K-H, Wu C-J.Antrodia cinnamomeaalleviates cisplatin-induced hepatotoxicity and enhances chemo-sensitivity of line-1 lung carcinoma xenografted in BALB/cByJ mice. Oncotarget. 2015; 6(28): 25741.

[7] Kart A, Cigremis Y, Karaman M, Ozen H. Caffeic acid phenethyl ester (CAPE) ameliorates cisplatin-induced hepatotoxicity in rabbit. Exp Toxicol Pathol. 2010; 62(1): 45-52.

[8] Karasawa T, Steyger PS. An integrated view of cisplatin-induced nephrotoxicity and ototoxicity. ToxicolLett. 2015; 237(3): 219-227.

[9] Tohamy AA, Aref AM, Moneim AEA, Sayed RH. Cinnamic acid attenuates cisplatin-induced hepatotoxicity and nephrotoxicity. J Basic Environ Sci. 2016; 3(1-9).

[10] Pandir D, Kara Ö. Cisplatin-induced kidney damage and the protective effect of bilberry (Vaccinium myrtillusL.): an experimental study. Turk J Med Sci. 2013; 43(6): 951-956.

[11] Omar HA, Mohamed WR, Arafa E-SA, Shehata BA, El Sherbiny GA, Arab HH,Elgendy AN.A.M.Hesperidin alleviates cisplatin-induced hepatotoxicity in rats without inhibiting its antitumor activity. Pharmacol Rep. 2016; 68(2): 349-356.

[12] Farooqui Z, Afsar M, Rizwan S, Khan AA, Khan F. Oral administration of Nigella sativaoil ameliorates the effect of cisplatin on membrane enzymes, carbohydrate metabolism and oxidative damage in rat liver. Toxicol Rep. 2016; 3: 328-335.

[13] Alizadeh NS, Khoei EM, Fazelimanesh M, Astaneh A. Antibacterial effects of Zataria multifloraboiss (shirazi avishan extract) on urinary tract Escherichia coliinfections. Res J Biol Sci. 2009; 4(8): 891-894.

[14] Norooznezhad AH, Keshavarz M, Norooznezhad F, Mansouri K. Inhibition of Angiogenesis: A Novel Effect of Zataria multiflora.Int J HematolOncol Stem Cell Res. 2017; 11(2): 96-101.

[15] Nakhai LA, Mohammadirad A, Yasa N, Minaie B, Nikfar S, Ghazanfari G, Zamani MJ, Dehghan G, Jamshidi H, Shetab Boushehri V, Khorasani R, Abdollahi M.Benefits of Zataria multifloraBoiss in experimental model of mouse inflammatory bowel disease. Evid-Based Compl Alt. 2007; 4(1): 43-50.

[16] Hosseinimehr SJ, Mahmoudzadeh A, Ahmadi A, Ashrafi SA, Shafaghati N, Hedayati N. The radioprotective effect of Zataria multifloraagainst genotoxicity induced by γ irradiation in human blood lymphocytes. Cancer Biother Radio. 2011; 26(3): 325-329.

[17] Hosseinimehr SJ, Ahmadashrafi S, Naghshvar F, Ahmadi A, Ehasnalavi S, Tanha M. Chemoprotective effects of Zataria multifloraagainst genotoxicity induced by cyclophosphamide in mice bone marrow cells. Integr Cancer Ther. 2010; 9(2): 219-223.

[18] Minaiyan M, Ghannadi A, Salehi E. Antiulcerogenic effect of Zataria multiflora Boiss. on cysteamine induced duodenal ulcer in rats. Iran J Pharm Sci. 2005; 1(4): 223-229.

[19] Shomali T, Raeesi M, Eskandari-Roozbahani N. Zataria multifloraBoiss. essential oil against ethanol-induced gastric ulcer in rats by antioxidant properties and increase in nitric oxide production. J HerbMed Pharmacol. 2016; 5(4): 143-148.

[20] Sharififar F, Moshafi M, Mansouri S, Khodashenas M, Khoshnoodi M. In vitro evaluation of antibacterial and antioxidant activities of the essential oil and methanol extract of endemic Zataria multifloraBoiss. Food Control. 2007; 18(7): 800-805.

[21] Mahboubi M, Bidgoli FG. Antistaphylococcal activity of Zataria multiflora essential oil and its synergy with vancomycin. Phytomedicine. 2010; 17(7): 548-550.

[22] Sajed H, Sahebkar A, Iranshahi M. Zataria multifloraBoiss.(Shirazi thyme)—an ancient condiment with modern pharmaceutical uses. J Ethnopharmacol. 2013; 145(3): 686-698.

[23] Peng Y, Zhang H, Liu R, Mine Y, McCallum J, Kirby C, Tsao R.Antioxidant and anti-inflammatory activities of pyranoanthocyanins and other polyphenols from staghorn sumac (Rhus hirtaL.) in Caco-2 cell models. J Funct Foods. 2016; 20:139-147.

[24] Arab H-A, Fathi M, Mortezai E, Hosseinimehr SJ. Chemoprotective effect of thymol against genotoxicity induced by bleomycin in human lymphocytes. Pharm Biomed Res. 2015; 1(1): 26-31.

[25] Ahmadipour A, Sharififar F, Nakhaipour F, Samanian M, Karami-Mohajeri S. Hepatoprotective effect of Zataria multifloraBoiss on cisplatin-induced oxidative stress in male rat. J Med Life. 2015; 8(4): 275-281.

[26] Almaghrabi OA. Molecular and biochemical investigations on the effect of quercetin on oxidative stress induced by cisplatin in rat kidney. Saudi J Biol Sci. 2015; 22(2): 227-231.

[27] Sinha S, Jothiramajayam M, Ghosh M, Jana A, Chatterji U, Mukherjee A. Vetiver oil (Java) attenuates cisplatin-induced oxidative stress, nephrotoxicity and myelosuppression in Swiss albino mice. Food Chem Toxicol. 2015; 81: 120-128.

[28] Tsikas D. Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges. Anal Biochem. 2017; 524: 13-30.

[29] Wei Q-Y, Chen W-F, Zhou B, Yang L, Liu Z-L. Inhibition of lipid peroxidation and protein oxidation in rat liver mitochondria by curcumin and its analogues. BBA-Gen Subjects. 2006; 1760(1): 70-77.

[30] Ahmadipour A, Sharififar F, Najafi A, Atashbar J, Karami-Mohajeri S. Preventive effect of methanolic extract of Zataria multifloraBoiss on liver toxicity of paracetamol in rats. J Med Life. 2015; 8(Spec Iss 4): 270-274.

[31] Hosseinimehr SJ, Asadian R, Naghshvar F, Azizi S, Jafarinejad M, Noaparast Z, Abdi SM, Hosseini SAH.Protective effects of thymol against nephrotoxicity induced by cisplatin with using 99mTc-DMSA in mice. Renal Failure. 2015; 37(2): 280-284.

[32] Saei-Dehkordi SS, Tajik H, Moradi M, Khalighi-Sigaroodi F. Chemical composition of essential oils in Zataria multifloraBoiss. from different parts of Iran and their radical scavenging and antimicrobial activity. Food Chem Toxicol. 2010; 48(6): 1562-1567.

[33] El-Sayed EM, Abd-Allah AR, Mansour AM, El-Arabey AA. Thymol and carvacrol prevent cisplatin‐induced nephrotoxicity by abrogation of oxidative stress, inflammation,and apoptosis in rats. J Biochem Mol Toxic. 2015; 29(4): 165-172.

[34] El‐Sayed ESM, Mansour AM, Abdul‐Hameed MS. Thymol and carvacrol prevent doxorubicin‐induced cardiotoxicity by abrogation of oxidative stress, inflammation, and apoptosis in rats. J Biochem Mol Toxic. 2016; 30(1): 37-44.

[35] Boskabady MH, Gholami Mhtaj L. Effect of the Zataria multifloraon systemic inflammation of experimental animals model of COPD. Biomed Res Int. 2014; 1-9.

[36] Dai W, Sun C, Huang S, Zhou Q. Carvacrol suppresses proliferation and invasion in human oral squamous cell carcinoma. OncoTargets Ther. 2016; 9: 2297-2304.

[37] Aksu EH, Kandemir FM, Altun S, Küçükler S, Çomaklı S, Ömür AD. Ameliorative effect of carvacrol on cisplatin‐induced reproductive damage in male rats. J Biochem Mol Toxic. 2016; 30(10): 513-520.

[38] Shergojri FA, Bhat BA, Gaur M. Amelioration of cisplatin induced hepatotoxicity in Swiss albino mice by gallic acid.Int J Eng Tech Sci Res. 2017; 4(12): 547-554.

[39] Afsar T, Razak S. Modulatory influence of Acacia hydaspica R. Parker ethyl acetate extract against cisplatin inveigled hepatic injury and dyslipidemia in rats. BMC Complem Altern M. 2017; 17(1): 307.

[40] Zeashan H, Amresh G, Singh S, Rao CV. Hepatoprotective and antioxidant activity of Amaranthus spinosus against CCl4induced toxicity. J Ethnopharmacol. 2009; 125(2): 364-366.

[41] Shokrzadeh M, Chabra A, Ahmadi A, Naghshvar F, Habibi E, Salehi F, Assadpour S.Hepatoprotective effects of Zataria multifloraethanolic extract on liver toxicity induced by cyclophosphamide in mice. Drug Res. 2015; 65(04): 169-175.

[42] Brozovic G, Orsolic N, Knezevic F, Knezevic AH, Benkovic V, Sakic K, Borojevic N,Dikic D.Thein vivogenotoxicity of cisplatin, isoflurane and halothane evaluated by alkaline comet assay in Swiss albino mice. J Appl Genetics. 2011; 52(3): 355-361.

[43] Shokoohinia Y, Khajouei S, Ahmadi F, Ghiasvand N, Hosseinzadeh L. Protective effect of bioactive compounds from Echinophora cinereaagainst cisplatin-induced oxidative stress and apoptosis in the PC12 cell line. Iran J Basic Med Sci. 2017; 20(4): 438-445.

[44] Qin S, Yang C, Wang X, Xu C, Li S, Zhang B, Ren H.Overexpression of Smac promotes Cisplatin-induced apoptosis by activating caspase-3 and caspase-9 in lung cancer A549 cells. Cancer Biother Radio. 2013; 28(2): 177-182.

[45] El-Sayed EM, Abd-Allah AR, Mansour AM, and EL-Arabey AA. Thymol and carvacrol prevent cisplatin‐induced nephrotoxicity by abrogation of oxidative stress, inflammation, and apoptosis in rats. J Biochem Mol Toxic. 2015; 29(4): 165-172.

[46] Aghamohammadi A, Azadbakht M, Hosseinimehr SJ. Quantification of thymol content in different extracts of Zataria multifloraby HPLC method. Pharm Biomed Res. 2016; 2(1):8-13.

[47] Aghamohammadi A, Hosseinimehr SJ, Ghasemi A, Azadbakht M, Pourfallah TA. Radiosensitization effects of a Zataria multiflora extract on human glioblastoma cells. Asian Pac J Cancer P. 2015; 16(16): 7285-7290.

[48] Naeimi RA, Amiri FT, Khalatbary AR, Ghasemi A, Zargari M, Ghesemi M, Hosseinimehr SJ.Atorvastatin mitigates testicular injuries induced by ionizing radiation in mice. Reprod Toxicol. 2017; 72:115-121.