Ankilozan spondilitli hastalarda komorbidite profilleri
Amaç: Ankilozan spondilit (AS) hastalarındaki komorbiditeleri ve klinik parametrelerle ilişkisini değerlendirmeyi amaçladık. Hastalar ve Yöntem: Çalışmaya 110 AS hastası dahil edildi. Hastalık aktivitesi Bath Ankilozan Spondilit Hastalık Aktivite İndeksi [Bath Ankylosing Disease Activity Index (BASDAI)] ile, fonksiyonel durum Bath Ankilozan Spondilit Fonksiyonel İndeks [Bath Ankylosing Spondylitis Functional Index (BASFI)] ile, spinal mobilite Bath Ankilozan Spondilit Metroloji İndeksi [Bath Ankylosing Spondylitis Metrology Index (BASMI)] ile ve yaşam kalitesi ise Nottingham Sağlık Profili [Nottingham Health Profile (NHP)] ile değerlendildi. Bulgular: Hastaların %28,18’inde komorbidite saptandı. Bunlar sırası ile peptik ülser (20,91%), hipertansiyon (%20), akciğer hastalığı (%15,45), diabetes mellitus (%13,64), osteoporoz (%10,91), iskemik kalp hastalığı (%10), böbrek hastalıkları (Ig A nefropatisi ve renal papiller nekroz, %1,82) ve kanserler (papiller tiroid kanseri ve renal hücreli kanser, %1,82) idi. Komorbiditesi bulunan hastalar BASDAI, BASMI, BASFI, VAS-ağrı ve NHP’nin ağrı, fiziksel mobilite ve enerji alt gruplarında belirgin olarak yüksek skorlama gösterdiler (p
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- 1. Braun J, Sieper J Ankylosing spondylitis. Lancet 2007; 369: 1379-90.
- 2. Gensler L. Clinical features of ankylosing spondylitis. In: MC Hochberg, AJ Silman, JS Smolen, ME Weinblatt, MH Weisman, editors. Rheumatology. 5th ed. Philadelphia: Mosby Elsevier, 2009: 1129-34.
- 3. Kang JH, Chen YH, Lin HC. Comorbidity profiles among patients with ankylosing spondylitis: a nationwide populationbased study. Ann Rheum Dis 2010;69: 1165-8. doi: 10.1136/ ard.2009.116178.
- 4. Bremander A, Petersson IF, Bergman S, Englund M. Population-based estimates of common comorbidities and cardiovascular disease in ankylosing spondylitis. Arthritis Care Res (Hoboken) 2011;63:550-6. doi: 10.1002/acr.20408.
- 5. Study protocol for the World Health Organization project to develop a Quality of Life assessment instrument (WHOQOL). Qual Life Res 1993;2:153-9.
- 6. Fortin M, Dubois MF, Hudon C, Soubhi H, Almirall J. Multimorbidity and quality of life: a closer look. Health Qual Life Outcomes 2007;5:52. doi: 10.1186/1477-7525-5- 52
- 7. Stolwijk C, van Tubergen A, Ramiro S, et al. Aspects of validity of the self-administered comorbidity questionnaire in patients with ankylosing spondylitis. Rheumatology (Oxford) 2014;53:1054-64.
- 8. Mercieca C, van der Horst-Bruinsma IE, Borg AA. Pulmonary, renal and neurological comorbidities in patients with ankylosing spondylitis; implications for clinical practice. Curr Rheumatol Rep 2014;16:434. doi: 10.1007/s11926-014- 0434-7.
- 9. Moll JM. New criteria for the diagnosis of ankylosing spondylitis. Scand J Rheumatol Suppl 1987;65:12-24
- 10. Sieper J, Rudwaleit M, Baraliakos X, et al. The Assessment of SpondyloArthritis International Society (ASAS) handbook: a guide to assess spondyloarthritis. Ann Rheum Dis 2009;68:1- 44. doi:10.1136/ard.2008.104018
- 11. Price DD, McGrath P, Rafii A, Buckingham B. The validation of visual analogue scales as ratio scale measures for chronic and experimental pain. Pain 1983; 17:45-56.
- 12. Akkoc Y, Karatepe AG, Akar S, Kirazli Y, Akkoc N. A Turkish version of the Bath Ankylosing Spondylitis Disease Activity Index: reliability and validity. Rheumatol Int 2005;25:280-4.
- 13. Calin A, Garrett S, Whitelock H, et al. A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index. J Rheumatol 1994;21:2281-5
- 14. Küçükdeveci AA, Mc Kenna SP, Kutlay S, Gürsel Y, Whalley D, Arasil T. The development and psycometric assessment of the Turkish version of the Nottingham Health Profile. Int J Rehabil Res 2000;23:31-8
- 15. Jenkinson TR, Mallorie PA, Whitelock HC, Kennedy LG, Garrett SL, Calin A. Defining spinal mobility in ankylosing spondylitis (AS): The Bath AS Metrology Index. J Rheumatol 1994;21:1694-8.
- 16. Bodur H, Ataman S, Buğdaycı DS, et al. Description of the registry of patients with ankylosing spondylitis in Turkey: TRASD-IP. Rheumatol Int 2012;32:169-76. doi: 10.1007/ s00296-010-1599-7
- 17. Casals-Sánchez JL, García De Yébenes Prous MJ, Descalzo Gallego MÁ, et al. Characteristics of patients with spondyloarthritis followed in rheumatology units in Spain. emAR II study. Reumatol Clin 2012;8:107-13
- 18. Ara RM, Packham JC, Haywood KL. The direct healthcare costs associated with ankylosing spondylitis patients attending a UK secondary care rheumatology unit. Rheumatology (Oxford) 2008;47:68-71.
- 19. Bostan EE, Borman P, Bodur H, Barca N. Functional disability and quality of life in patients with ankylosing spondylitis. Rheumatol Int 2003; 23: 121-6.
- 20. Brunner R, Kissling RO, Auckenthaler C, Fortin J. Clinical evaluation of ankylosing spondylitis in Switzerland. Pain Physician 2002; 5: 49-56.
- 21. Collantes E, Zarco P, Muñoz E, et al. Disease pattern of spondyloarthropathies in Spain: description of the first national registry (REGISPONSER) extended report. Rheumatology (Oxford) 2007;46:1309-15.
- 22. Tayel MY, Soliman E, El Baz WF, El Labaan A, Hamaad Y,Ahmed MH. Registry of the clinical characteristics of spondyloarthritis in a cohort of Egyptian population. Rheumatol Int 2012; 32:2837-42. doi: 10.1007/s00296-011-2068-7
- 23. Ariza-Ariza R, Hernández-Cruz B, López-Antequera G, Navarro-Sarabia F. Variables related to utility in patients with ankylosing spondylitis. Clin Rheumatol 2009;28: 207- 11. doi: 10.1007/s10067-008-1019-5
- 24. Boonen A, Chorus A, Miedema H, et al. Withdrawal from labour force due to work disability in patients with ankylosing spondylitis. Ann Rheum Dis 2001; 60: 1033-9.
- 25. Salaffi F, Carotti M, Gasparini S, Intorcia M, Grassi W. The health-related quality of life in rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis: a comparison with a selected sample of healthy people. Health Qual Life Outcomes 2009;7:25. doi: 10.1186/1477-7525-7-25