Neonatal İshalli Buzağılarda 25 (OH) D3 Konsantrasyonlarının Araştırılması

Bu araştırma ile neonatal dönemde ishal semptomu gösteren buzağıların plazma vitamin D3 ve fibrinojen konsantrasyonları arasındaki ilişkinin belirlenmesi amaçlandı. Bu kapsamda neonatal ishalli (n=100) ve sağlıklı (n=20) buzağılar araştırmaya dahil edildi. İshalli buzağılar kendi içerisinde mono enfekte ve ko enfeksiyon gruplarına göre iki ana gruba, mono-enfekte buzağılar kendi içerisinde E. coli, Rotavirus, Coronavirus, Cryptosporidium sp., ve Giardia sp., ko-enfekte buzağılar ise Rotavirus + Cryptosporidium sp. ve E. coli + Cryptosporidium sp. olacak şekilde alt gruplara ayrıldı. Buzağıların %6’sının E. coli, %19’u Cryptosporidium sp., %13’ü Rotavirus, %6’sı Coronovirus, %6’sı Giardia ile mono-enfekte, ko-enfekte buzağıların ise %11’i E. coli + Cryptosporidium sp., ve %22’sinin Rotavirüs + Cryptosporidium sp., ile enfekte ve %17’nin sağlıklı olduğu belirlendi. Sağlıklı buzağılara göre mono enfekte ve ko-enfekte buzağıların fibrinojen konsantrasyonlarının anlamlı düzeyde yüksek olduğu buna karşın 25 (OH) D3 seviyelerinin ise her iki grupta sağlıklı buzağılara göre anlamlı derecede düşük olduğu belirlendi. İshalli buzağılarda fibrinojen ve 25 (OH) D3 konsantrasyonları arasında (r= - 403, p<0,05) negatif korelasyon bulunduğu belirlendi. Sonuç olarak 25 (OH) D3 konsantrasyonlarının ishalli buzağılarda enfeksiyonun varlığı ve şiddetine bağlı olarak azaldığı tespit edildi.

Anahtar Kelimeler:

Akut faz protein, Buzağı, Fibrinojen, İshal, Vitamin D3

Evaluation of 25 (OH) D3 Concentrations in Neonatal Calves with Diarrhea

In the present study the aim was to determine the relationship between plasma vitamin D3 and fibrinogen concentrations of calves with diarrhea. İn this context, calves neonatal diarrhea (n = 100) and healthy (n = 20) ones were enrolled. Diarrheic calves were enrolled into two intra-groups of mono and co-infected, then mono-infected calves and co-infected calves were divided into subgroups according to E. coli, Rotavirus, Coronavirus, Cryptosporidium sp., and Giardia sp., and Rotavirus + Cryptosporidium sp. and E. Coli + Cryptosporidium sp. It was determined that 6% of the calves were infected with and E.coli, 13% Rotavirus, 6% Coronavirus, 6% Giardia in mono-infected ones and 11% E.coli + Cryptosporidium sp., and 22% Rotavirus + Cryptosporidium sp., with co-infection and 17% healthy. According to healthy calves, mono-infected and co-infected calves had significantly higher fibrinogen concentrations, whereas 25 (OH) D3 levels were significantly lower in both groups than healthy calves. There was a negative correlation between fibrinogen and 25 (OH) D3 concentrations (r = - 403, p <0.05) in calves with diarrhea. As a result, 25 (OH) D3 concentrations decreased in diarrhea calves due to the presence and severity of the infection.

Keywords:

vitamin D3, Calf, fibrinogen, diarrhea,

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