The Protective Effect of Kefir on Carbon Tetrachloride-induced Histopathological Changes in the Livers of Rats

Çalışmada deneysel karbon tetraklorür (CCI4) toksikasyonu oluşturulan ratlarda kefirin karaciğer hasarına karşı koruyucu etkilerinin histolojik ve immunohistokimyasal olarak araştırılması amaçlandı. Kırkbeş günlük deneme boyunca, 18 adet, dişi, Wistar albino rat kullanıldı. Biri kontrol olmak üzere, üç deneme grubu oluşturuldu. Grup 2 ve 3'e haftada 2 kez 0.5 cc karbon tetraklorür (CCI4) + zeytinyağı (1:1) süspansiyonu subkutan yolla verildi. Grup 3'e buna ek olarak günlük 30 ml kefir oral gavaj yoluyla verildi. CCI4'e bağlı hepatoselüler dejenerasyon ve apoptosis gözlendi, ancak kefir eklenmesi ile bu olumsuz değişiklikler azaldı. Bu bulgular kefirin karaciğer hasarında koruyucu rolü olabileceğini gösterdi.

Karbon Tetraklorüre Bağlı Ratların Karaciğerinde Oluşan Histopatolojik Değişikliklere Karşı Kefirin Koruyucu Etkisi

The aim of the study was to investigate the protective effects of kefir in the liver damage of rats, at experimental carbon tetrachloride (CCI4) intoxication by histologically and immunohistochemically. During the 45 days trial period, 18, female, Wistar albino rats were used. One of them was control, three experimental group was created. Twice a week 0.5 cc carbon tetrachloride (CCI4) + olive-oil (1:1) suspension was injected subcutaneously to the second and third group. At third group additionally to this administration 30 ml kefir was given daily by oral gavage. CCI4-induced hepatocellular damage and apoptosis was observed but these adverse findings reduced with kefir administration. These findings indicate that kefir may have a protective role at liver damage.

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