ERDOĞAN UZLU, MAHMUT KARAPEHLİVAN, HİDAYET METİN ERDOĞAN, Şemistan KIZILTEPE, EKİN EMRE ERKILIÇ, Hacı Ahmet DEVECİ, ERHAN GÖKÇE, İNAN KAYA, MEHMET ÇİTİL

Serum and Saliva Sialic Acid and Oxidative Stress Parameters Changes in Bulls with Foot and Mouth Disease [1]

Bu çalışmada 18-36 ay yaşları arasında klinik açıdan şiddetli şap belirtileri tespit edilen 12 ve aynı yaş aralığındaki sağlıklı 10 adet boğa değerlendirildi. Serum ve salyada total sialik asit (SA), malondialdehit (MDA), glutathione (GSH) ve nitrik oksit (NO) düzeyleri ölçüldü. Çalışmada klinik belirtiler olarak; akut ateş, iştahsızlık, ağızda çok yaygın veziküler lezyonlar ve buna bağlı aşırı salivasyon, şiddetli topallık ve verim düşüklüğü belirlendi. Sağlıklı boğalarda ortalama serum SA, MDA, GSH ve NO düzeyleri sırasıyla 503.96±21.43 mg/L, 31.82±3.43 µmol/L, 63.43±2.92 mg/dL ve 6.49±0.36 nmol/L, şaplı olarak değerlendirilen boğalarda ise 862.01±17.35 mg/L, 82.49±9.90 µmol/L, 24.96±2.32 mg/dL ve 13.89±0.53 nmol/L olarak belirlendi. Sağlıklı boğalardan elde edilen salyalarda ortalama SA, MDA, GSH ve NO düzeyleri sırasıyla 75.98±10.25 mg/L, 1.06±0.17 µmol/L, 0.67±0.05 mg/dL ve 1.44±0.14 nmol/L iken bu değerler şaplı olarak değerlendirilen boğalarda 156.49±14.07 mg/L, 1.81±0.15 µmol/L 0.34±0.03 mg/dL ve 2.44±0.16 nmol/L, olarak tespit edildi. İki grup arasındaki farkın istatistiksel olarak anlamlı olduğu belirlendi (P

Şap Hastalıklı Boğalarda Serum ve Salya Sialik Asit ve Oksidatif Stres Parametrelerindeki Değişiklikler

The study comprised of 12 bulls, aged between 18-36 months, determined severe symptoms of Foot-and-mouth disease (FMD) and 10 clinically healthy bulls of similar age. Serum and saliva total sialic acid (SA), malondialdehyde (MDA), glutathione (GSH) and nitric oxide (NO) levels were measured. In this study were determined acute fever, anorexia, vesicular lesions in the mouth and feet of infected animals with consequent excessive salivation, lameness and reduced productivity as clinical signs. Mean serum SA, MDA, GSH and NO levels were 503.96±21.43 mg/L, 31.82±3.43 µmol/L, 63.43±2.92 mg/dL, and 6.49±0.36 nmol/L in healthy bulls and 862.01±17.35 mg/L, 82.49±9.90 µmol/L, 24.96±2.32 mg/dL, and 13.89±0.53 nmol/L in FMD cases, respectively. Mean saliva SA, MDA, GSH and NO levels were 75.98±10.25 mg/L, 1.06±0.17 µmol/L, 0.67±0.05 mg/dL, and 1.44±0.14 nmol/L in healthy bulls and 156.49±14.07 mg/L, 1.81±0.15 µmol/L, 0.34±0.03 mg/dL, and 2.44±0.16 nmol/L in FMD cases, respectively. The differences between the two groups were statistically significant (P<0.001 and P<0.01). Mean serum and saliva GSH level was lower in FMD while all other parameters were considerable high. As a result, showing signs of foot and mouth disease in bulls, serum and saliva in sialic acid and oxidative stress parameters are affected very significantly.

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