Hasan ÇANTAY, Turgut ANUK, Uğur AYDIN, Emin KARAKURT, Uğur YILDIZ, Hilmi NUHOĞLU

The Eff ect of Synovial Fluid as a Natural Source of Hyaluronic Acid on Limberg Flap and Elliptical Rotation Flap Healing: A Comparative Study of Full-Thickness Excisional Dermal Wounds in Mice

The purpose of this study was to investigate the effi cacy of synovial fl uid (SF) as a source of hyaluronic acid (HA) on Limberg and Elliptical rotationfl ap healing. In this study conducted on 24 male Mus musculus mice, the animals were divided into 2 main groups. Group 1 (n = 12): Limbergfl apgroup; Group 2 (n = 12) Elliptical rotation fl ap group. Six of the animals in Group 1 and Group 2 were assigned as the Flap (Control) Group, and 6 asthe Flap + SF Group. In SF subgroups of animals in each group, 1 mL SF was injected into the operation area in addition to the fl ap surgical procedure.The groups were compared in terms of epithelialization, angiogenesis, neutrophil leukocyte infiltration and fibroblast activity, and the eff ect of SFon the infl ammation and wound healing was evaluated. It was observed that epithelization was completed in all animals in the groups which wereadministered compared to the other groups, and there was a statistically significant diff erence (P

Doğal Bir Hyaluronik Asit Kaynağı Olarak Sinovyal Sıvının Limberg Flep ve Eliptik Rotasyon Flep İyileşmesi Üzerine Etkisi: Farelerde Tam Katmanlı Eksizyonel Dermal Yaralarda Karşılaştırmalı Bir Çalışma

Bu çalışmada, doğal bir hyaluronik asit (HA) kaynağı olarak sinovyal sıvının (SS) Limberg ve Eliptik rotasyon fl ep iyileşmesi üzerine etkinliğinin araştırılması amaçlandı. Yirmi dört adet erkek Mus musculus cinsi fare üzerinde yapılan bu çalışmada hayvanlar 2 ana gruba ayrıldı. Grup 1 (n=12): Limberg fl ep grubu; Grup 2 (n=12) Eliptik rotasyon fl ep grubu. Grup 1 ve Grup 2’deki hayvanların 6’sı Flep (Kontrol) Grubu, 6’sı ise Flep + SS Grubu olarak ayrıldı. Her bir gruptaki hayvanların SS alt gruplarında fl ep cerrahi prosedürüne ek olarak operasyon bölgesine 1 mL SS enjekte edildi. Epitelizasyon, anjiyogenezis, nötrofil lökosit infiltrasyonu ve fibroblast aktivitesi yönünden gruplar karşılaştırılarak SS’nın fl ep viabilitesi ve yara iyileşmesine olan etkisi değerlendirildi. SS uygulanan gruplarda hayvanların tamamında, diğer gruplara göre epitelizasyonun tamamlandığı ve istatistiksel olarak anlamlı farklılık olduğu görüldü (P

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