MEHMET ŞAHAL, ABDÜLKERİM DENİZ, Rıfat VURAL, ŞÜKRÜ KÜPLÜLÜ, İBRAHİM MERT POLAT, EKREM ÇAĞATAY ÇOLAKOĞLU, NACİ ÖCAL, Hasan Ceyhun MACUN, MERT PEKCAN, Marion OCAK

Evaluation of the Effect of Different Doses of Butaphosphan and Cyanocobalamin Combination in Dairy Cattle with Subclinical Ketosis

Bu çalışma, subklinik ketozisli (SCK) süt ineklerinde farklı dozlarda butafosfan-siyanokobalamin kombinasyonunun vücut kondisyon skoru (VKS), betahidroksibütirat (BHBA) ve reprodüktif parametreler üzerine etkilerini değerlendirmek amacıyla gerçekleştirildi. Holştayn-Frizyan inekler (n=544) BHBA yönünden kontrol edildi. SCK'li inekler (n=53, 1.00-3.00 mmol/L BHBA); 4 gün süresince günlük salin uygulanan (C0, n=18) ve canlı ağırlığa 5 mL/100 kg dozunda (C5, n=18) ya da canlı ağırlığa 10 mL/100 kg dozunda (C10, n=17) butafosfan-siyanokobalamin kombinasyonunun uygulandığı gruplara rastgele olarak ayrıldı. BHBA düzeyleri; 0, 10 ve 18. günlerde ölçüldü. VKS postpartum 60. güne kadar haftalık değerlendirildi. Reprodüktif parametreler için inekler doğum sonrası 150. güne kadar takip edildi. Kan BHBA düzeyinde medyan azalma C0, C5 ve C10 grubunda sırasıyla %28, %57 ve %75 olarak gerçekleşti. NEFA ve total bilirübin düzeyleri C10 grubunda anlamlı şekilde azaldı. VKS'un relatif medyan değişimi baseline ile karşılaştırıldığında C0, C5 ve C10 grubunda sırasıyla %17, %12 ve %6 olarak belirlendi. Postpartum 15 ve 25. günler arasında uterus involüsyonu C0, C5 ve C10 gruplarında sırasıyla %44, %83 ve %88 tamamlandı. C10 grubunda buzağılama ilk tohumlama aralığı kontrol grubundan daha kısaydı. Ortalama gebelik oranı gruplar arasında farklılık göstermedi. Sonuç olarak butafosfan-siyanokobalamin kombinasyonu; hiperketonomi şiddetini azalttı, uterus involüsyonunu uyardı, ilk tohumlama zamanını kısalttı ve gebelik oranını arttırdı

Subklinik Ketosisli Süt İneklerinde Farklı Dozlarda Butafosfan ve Siyanokobalamin Kombinasyonunun Etkisinin Değerlendirilmesi

This study was conducted to assess the effects of different doses of butaphosphan-cyanocobalamin combination onbody condition score (BCS), betahydroxybutyrate (BHBA) and reproductive parameters in cows with subclinical ketosis (SCK). Holstein-Friesen cows (n=544) were checked for BHBA concentration. Cows with SCK (n=53, BHBA ranging from 1.00 to 3.00 mmol/L) were assigned randomly to receive saline (C0, n=18), 5 mL/100 kg BW (C5, n=18) or 10 mL/100 kg BW (C10, n=17) butaphosphan-cyanocobalamin combination. BHBA concentration was measured on d 0, 10, and 18 relative to treatment application. BCS was evaluated weekly until d 60 postpartum. For reproductive parameters cows were monitored until d 150 postpartum. The median reduction in blood BHBA concentrations was 28, 57, and 75% for C0, C5, and C10, respectively. NEFA and total bilirubin concentrations were significantly decreased in C10 group. The relative median change in BCS as compared to baseline was 17, 12, and 6% for C0, C5, and C10, respectively. Between d 15 and 25 postpartum uterine involution was completed in 44, 83, and 88% of cows in groups C0, C5, and C10, respectively. Interval from calving to first insemination in group C10 was shorter than control group. Overall pregnancy rate was not different among groups. In conclusion butaphosphan-cyanocobalamin combination decreased severity of hyperketonemia, stimulated uterine involution, shortened time to first insemination and increased pregnancy rate

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