Le-Ying ZHANG, Pei-Bin QU, Yan TU, Chun-Tao YANG, Qi-Yu DIAO

Effects of Flavonoids from Mulberry Leaves and Candida tropicalison Performance and Nutrient Digestibility in Calves

Dut yaprağından elde edilen flavonoidler (FML) doğal flavonoidler olup Candida tropicalis (CT) de mantar benzeri mikroplardır. Bu çalışmada, doğumda 40.5±0.7 kg ağırlığa sahip 20±2 günlük kırk sekiz erkek buzağı kullanılarak rastgele 4 gruba ayrıldı. FML sütten kesme öncesi her bir buzağı için 2 g/d olarak buzağı başlangıç yemi içerisinde veya her bir buzağı için 4 g/d olarak sütten kesme sonrası (FML grup), CT ise her bir buzağı için 1 g/d olarak buzağı başlangıç yemi içerisinde (CT grup) verildi. Çalışma sonucunda FML'nin diyetin eter ekstraktının (EE) sindirilebilirliğini ve serum büyüme hormonu (GH) ve insülin benzeri büyüme faktörü 1 (IGF-1)'in seviyelerini belirgin bir şekilde arttırmak yoluyla 56 günlükten sonrasında buzağıların vücut ağırlığını (BW) geliştirmek amacıyla kullanılabileceği tespit edilmiştir. CT; buzağıların vücut ağırlığını sütten kesme öncesinde diyetteki nötr deterjan fiberin sindirilebilirliğini belirgin ölçüde geliştirdi ve serum IGF-1'in seviyesini yükseltmek suretiyle sütten kesme sonrasında diyetteki eter ekstraktının sindirilebilirliğini belirgin ölçüde artırdı. FML ve CT karışımı büyümeyi geliştirme, gıda tüketimini ve besin sindirilebilirliğini iyileştirmekte sinerjistik bir rol oynadı. Sonuç olarak, FML ve CT büyüme ve besin sindirilebilirliğini artırmak amacıyla buzağılarda bir katkı olarak kullanılabilir

Dut Yaprağından Elde Edilen Flavonoidler İle Candida tropicalis'in Buzağılarda Performans ve Besin Sindirilebilirliği Üzerine Etkileri

Flavonoids from mulberry leave (FML) are natural flavonoids, and Candida tropicalis (CT) is yeast like microbe. In this study, forty-eight male calves were selected with born weight (40.5±0.7 kg) and 20±2 days age, divided into 4 groups randomly. FML was supplemented in a dairy calf starter at 2 g/d per calf before weaning, or 4 g/d per calf after weaning (FML group), while CT was added in a dairy calf starter at 1 g/d per calf (CT group). Our results showed that FML could be used to enhance body weight (BW) of calves through enhancing apparent digestibility of ether extract (EE) of the diet, and increased the levels of serum growth hormone (GH) and insulin-like growth factors 1 (IGF-1) in calves after the age of 56 days. CT enhanced the BW of calves before weaning through increasing the apparent digestibility of neutral detergent fiber (NDF) of the diet, and elevated the apparent digestibility of EE of the diet of calves after weaning through increasing the level of serum IGF-1 in calves. Furthermore, the mixture of FML and CT plays a synergistic role in enhancing growth, improving feed intake and nutriment digestibility. In conclusion, FML and CT could be used as additives to increase growth and nutrient digestibility in calves

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Redding LE, Cubas-Delgado F, Sammel MD, Smith G, Galligan DT,
Levy MZ, hennessy S: The use of antibiotics on small dairy farms in rural Peru. Prev Vet Med, 113, 88-95, 2014. DOI: 10.1016/j.prevetmed. 10.012
Bell L, Lamport DJ, Butler LT, Williams CM: A review of the cognitive effects observed in humans following acute supplementation with flavonoids, and their associated mechanisms of action. Nutrients, 7, 10306, 2015. DOI: 10.3390/nu7125538
Vezza T, Rodríguez-Nogales a, algieri F, Utrilla MP, Rodriguez- Cabezas ME, Galvez J: Flavonoids in inflammatory bowel disease: A review. Nutrients, 8, 211, 2016. DOI: 10.3390/nu8040211
Jenkins KJ, atwal aS: Flavonoids increase tissue essential fatty acids in vitamin E-deficient chicks. J Nutr Biochem, 6, 97-103, 1995. DOI: 1016/0955-2863(94)00018-H
Soltan Ya, Morsy aS, Sallam SM, Lucas RC, Louvandini h, Kreuzer M, abdalla aL: Contribution of condensed tannins and mimosine to the methane mitigation caused by feeding Leucaena leucocephala. Arch Anim Nutr, 67, 169-184, 2013. Arch Anim Nutr, 2013. DOI: 1080/1745039X.2013.801139
Balcells J, aris a, Serrano a, Seradj aR, Crespo J, Devant M: Effects of an extract of plant flavonoids (Bioflavex) on rumen fermentation and performance in heifers fed high-concentrate diets. J Anim Sci, 90, 4975- , 2012. DOI: 10.2527/jas.2011-4955
Girard M, Dohme-Meier F, Silacci P, ampuero Kragten S, Kreuzer M, Bee G: Forage legumes rich in condensed tannins may increase n-3 fatty acid levels and sensory quality of lamb meat. J Sci Food Agric, 96,1923- 2016. DOI: 10.1002/jsfa.7298
El-Sayyad hI, El-Sherbiny Ma, Sobh Ma, abou-El-Naga aM, Ibrahim Ma, Mousa Sa: Protective effects of Morus alba leaves extract on ocular functions of pups from diabetic and hypercholesterolemic mother rats. Int J Biol Sci, 7, 715-728, 2011. DOI: 10.7150/ijbs.7.715
Wong a, Ngu DY, Dan La, Ooi a, Lim RL: Detection of antibiotic resistance in probiotics of dietary supplements. Nutr J, 14, 95, 2015. DOI: 1186/s12937-015-0084-2
Paserakung a, Pattarajinda V, Vichitphan K, Froetschel Ma: Selection and identification of oleaginous yeast isolated from soil, animal feed and ruminal fluid for use as feed supplement in dairy cattle. Lett Appl Microbiol, 61, 325-332, 2015. DOI: 10.1111/lam.12475
Jensen GS, Patterson KM, Yoon I. Yeast culture has anti-inflammatory effects and specifically activates NK cells. Comp Immunol Microbiol Infect Dis, 31, 487-500, 2008. DOI: 10.1016/j.cimid.2007.08.005
Jensen GS, hart aN, Schauss aG: An antiinflammatory immunogen from yeast culture induces activation and alters chemokine receptor expression on human natural killer cells and B lymphocytes in vitro. Nutr Res, 27, 327-335, 2007. DOI: 10.1016/j.nutres.2007.04.008
Brewer MT, anderson KL, Yoon I, Scott MF, Carlson Sa: Amelioration of salmonellosis in pre-weaned dairy calves fed Saccharomyces cerevisiae fermentation products in feed and milk replacer. Vet Microbiol, 172, 248- , 2014. DOI: 10.1016/j.vetmic.2014.05.026
Uyeno Y, Shigemori S, Shimosato T: Effect of probiotics/prebiotics on cattle health and productivity. Microbes Environ, 30, 126-132, 2015. DOI: 10.1264/jsme2.ME14176
Silva S, Negri M, henriques M, Oliveira R, Williams DW, azeredo J: Candida glabrata, Candida parapsilosis and Candida tropicalis: Biology, epidemiology, pathogenicity and antifungal resistance. FEMS Microbiol Rev, 36, 288-305, 2012. DOI: 10.1111/j.1574-6976.2011.00278.x
Renaville R, hammadi M, Portetelle D: Role of the somatotropic axis in the mammalian metabolism. Domest Anim Endocrinol, 23, 351-360, DOI: 10.1016/S0739-7240(02)00170-4
Kammes KL, allen MS: Nutrient demand interacts with grass particle length to affect digestion responses and chewing activity in dairy cows. J Dairy Sci, 95, 807-823, 2012. DOI: 10.3168/jds.2011-4588
Mejía M, Gonzalez-Iglesias a, Díaz-Torga GS, Villafañe P, Formía N, Libertun C, Becş-Villalobos D, Lacau-Mengido IM: Effects of continuous ivermectin treatment from birth to puberty on growth and reproduction in dairy heifers. J Anim Sci, 77, 1329-1334, 1999. DOI: 2527/1999.7761329x
Casewell M, Friis C, Marco E, McMullin P, Phillips I: The European ban on growth-promoting antibiotics and emerging consequences for human and animal health. J Antimicrob Chemother, 52, 159-161, 2003. DOI: 10.1093/jac/dkg313
Yang C, Chowdhury Ma, huo Y, Gong J: Phytogenic compounds as alternatives to in-feed antibiotics: Potentials and challenges in application. Pathogens 4, 137-56, 2015. DOI: 10.3390/pathogens4010137
Yaghoubi SM, Ghorbani GR, Rahmani hR, Nikkhah a: Growth, weaning performance and blood indicators of humoral immunity in Holstein calves fed supplemental flavonoids. J Anim Physiol Anim Nutr (Berl), 92, 456-462, 2008. DOI: 10.1111/j.1439-0396.2007.00734.x
Rodriguez-Mateos a, Vauzour D, Krueger CG, Shanmuganayagam D, Reed J, Calani L, Mena P, Del Rio D, Crozier a: Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: An update. Arch Toxicol, 88, 1803-1853, 2014. DOI: 10.1007/ s00204-014-1330-7
Kobayashi Y, Miyazawa M, Kamei a, abe K, Kojima T: Ameliorative effects of mulberry (Morus alba L.) leaves on hyperlipidemia in rats fed a high-fat diet: Induction of fatty acid oxidation, inhibition of lipogenesis, and suppression of oxidative stress. Biosci Biotechnol Biochem, 74, 2385- , 2010. DOI: 10.1271/bbb.100392
Beauchemin Ka, McGinn SM, Martinez TF, Mcallister Ta: Use of condensed tannin extract from quebracho trees to reduce methane emissions from cattle. J Anim Sci, 85, 1990-1996, 2007. DOI: 10.2527/ jas.2006-686
Benchaar C, Chouinard PY: Short communication: Assessment of the potential of cinnamaldehyde, condensed tannins, and saponins to modify milk fatty acid composition of dairy cows. J Dairy Sci, 92, 3392- 2009. DOI: 10.3168/jds.2009-2111
Zin SR, Omar SZ, Khan NL, Musameh NI, Das S, Kassim NM: Effects of the phytoestrogen genistein on the development of the reproductive system of Sprague Dawley rats. Clinics (Sao Paulo), 68, 253-262, 2013. DOI: 6061/clinics/2013(02)OA21
Böttner M, Christoffel J, Wuttke W: Effects of long-term treatment with 8-prenylnaringenin and oral estradiol on the GH-IGF-1 axis and lipid metabolism in rats. J Endocrinol, 198, 395-401, 2008. DOI: 10.1677/JOE08
Romero CJ, Pine-Twaddell E, Sima DI, Miller RS, he L, Wondisford F, Radovick S: Insulin-like growth factor 1 mediates negative feed- back to somatotroph GH expression via POU1F1/CREB binding protein interactions. Mol Cell Biol, 32, 4258-4269, 2012. DOI: 10.1128/ MCB.00171-12
Zhou Y, Capuco aV, Jiang h: Involvement of connective tissue growth factor (CTGF) in insulin-like growth factor-I (IGF1) stimulation of proliferation of a bovine mammary epithelial cell line. Domest Anim Endocrinol, 35, 180-189, 2008. DOI: 10.1016/j.domaniend.2008.05.003
Malekkhahi M, Tahmasbi aM, Naserian aa, Danesh Mesgaran M, Kleen JL, Parand aa: Effects of essential oils, yeast culture and malate on rumen fermentation, blood metabolites, growth performance and nutrient digestibility of Baluchi lambs fed high-concentrate diets. J Anim Physiol Anim Nutr (Berl), 99, 221-229, 2015. DOI: 10.1111/jpn.12230 hill SR, hopkins Ba, Davidson S, Bolt SM, Diaz DE, Brownie C,
Brown T, huntington GB, Whitlow LW: The addition of cottonseed hulls to the starter and supplementation of live yeast or mannanoligosaccharide in the milk for young calves. J Dairy Sci, 92, 790-798, 2009. DOI: 10.3168/ jds.2008-1320
Lesmeister KE, heinrichs aJ, Gabler MT: Effects of supplemental yeast (Saccharomyces cerevisiae) culture on rumen development, growth characteristics, and blood parameters in neonatal dairy calves. J Dairy Sci, , 1832-1839, 2004. DOI: 10.3168/jds.S0022-0302(04)73340-8
Galvão KN, Santos JE, Coscioni a, Villaseñor M, Sischo WM, Berge aC: Effect of feeding live yeast products to calves with failure of passive transfer on performance and patterns of antibiotic resistance in fecal Escherichia coli. Reprod Nutr Dev, 45, 427-440, 2005. DOI: 10.1051/ rnd:2005040
Fonty G, Chaucheyras-Durand F: Effects and modes of action of live yeasts in the rumen. Biologia, 61, 741-750, 2006. DOI: 10.2478/s11756- 0151-4
Gebru E, Lee JS, Son JC, Yang SY, Shin Sa, Kim B, Kim MK, Park SC: Effect of probiotic-, bacteriophage-, or organic acid-supplemented feeds or fermented soybean meal on the growth performance, acute- phase response, and bacterial shedding of grower pigs challenged with Salmonella enterica serotype Typhimurium. J Anim Sci, 88, 3880-3886, DOI: 10.2527/jas.2010-2939
avella Ma, Place a, Du SJ, Williams E, Silvi S, Zohar Y, Carnevali O: Lactobacillus rhamnosus accelerates zebrafish backbone calcification and gonadal differentiation through effects on the GnRH and IGF systems. PlosOne, 7, e45572, 2012. DOI: 10.1371/journal.pone.0045572