EKİN EMRE ERKILIÇ, METİN ÖĞÜN, ALİ HAYDAR KIRMIZIGÜL, YASEMEN ADALI, CELAL ŞAHİN ERMUTLU, HÜSEYİN AVNİ EROĞLU, ABDULSAMED KÜKÜRT, MEHMET ÇİTİL, ERDOĞAN UZLU

Determination of Some Oxidative Stress and Inflammation Markers in Serum, Blood and CSF in Cattle with Head-Eye Form of Malignant Catarrhal Fever

Bu çalışmanın amacı Koriza Gangrenosa Bovum'lu sığırlarda serum ve beyin omurilik sıvısı (BOS), total sialik asit (TSA), malondialdehit (MDA), nitrik oksit (NO), indüklenebilir nitrik oksit sentetaz (iNOS) ve endotelyal nitrik oksit sentetaz (eNOS) ile kan redükte glutatyon (GSH), düzey değişikliklerinin belirlenmesidir. Bu amaçla klinik olarak Coryza Gangrenosa Bovum'un (CGB) "Baş-Göz Formu" teşhisi konulan 17 adet ve kontrol amacı ile klinik olarak sağlıklı sığırlardan oluşan 10 adet sığır değerlendirildi. Hasta ve kontrol gruplarındaki hayvanlardan kan ve BOS alındı. CGB teşhisi konulan grupta MDA, GSH, NO, eNOS, iNOS ve TSA değerlerinin sırası ile 25.65±0.42 µmol/L, 37.21±1.12 mg/dL, 30.61±0.41 µmol/L, 4.05±0.09 U/L ve 10.98±0.35 U/L, 88.33±1.03 mg/dL kontrol grubunda ise 13.77±0.55 µmol/L, 60.06±1.73 mg/dL, 11.27±0.4 µmol/L, 3.12±0.18 U/L, 5.55±0.3 U/L ve 63.60±1.86 mg/dL olduğu ve tüm parametre değişikliklerinin gruplar arasında istatistiksel olarak önemli (P

Koriza Gangrenosa Bovum Baş-Göz Formlu Sığırlarda Serum, Kan ve BOS’ta Bazı Oksidatif Stres ve İnflamasyon Belirteçlerinin Tespiti

The aim of this study was to determine changes in total sialic acid (TSA), malondialdehyde (MDA), nitric oxide (NO), inducible nitric oxide synthase (iNOS) and endothelial nitric oxide synthase (eNOS) levels on sera and CSF and reduced glutathione (GSH) levels on blood in cattle with Malignant Catarrhal Fever (MCF). For this purpose 17 cattle which clinically diagnosed “head-eye form” of MCF and clinically healthy 10 cattle were evaluated. Blood and cerebrospinal fluid (CSF) were taken from the animals on the MCF diagnosed group MDA, GSH, NO, eNOS, iNOS, and TSA values were 25.65±0.42 µmol/L, 37.21±1.12 mg/dL, 30.61±0.41 µmol/L, 4.05±0.09 U/L and 10.98±0.35 U/L, 88.33±1.03 mg/dL, on the control group 13.77±0.55 µmol/L, 60.06±1.73 mg/dL, 11.27±0.4 µmol/L, 3.12±0.18 U/L, 5.55±0.3 U/L and 63.60±1.86 mg/dL respectively, and all parameter changes between the groups were determined to be statistically significant (P

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