Hazal OZTURK-GURGEN, Aydın GÜREL, Evrim EGEDEN, Özlem CALP-EGEDEN

Abdominal Wall Hibernoma in a Cat: A Case Report

Hibernoma is a very rare benign tumor of brown fat tissue which is found in hibernating and non-hibernating mammals. Until now, it has been reported in rats, dogs, and human beings. In this case report, a thirteen-year-old, spayed, female Siamese cat was examined for intestinal motility disorder. Local obstruction of the colon descendens was observed on radiographs 72 h after contrast medium administration. In order for the abdominal organs to be examined, diagnostic laparotomy was performed. A mass 1 cm in diameter located on the abdominal wall showing adhesion to mesenterium of the colon descendens was observed and completely removed. Post-operative treatment was maintained by intestinal diet, metoclopramide, and enrofloxacin administration. Histopathological examination of the mass revealed hibernoma, a benign tumor of brown fat tissue. Further immunohistochemical analyses were performed to evaluate the origin and behavior of the tumor by using S-100 and osteopontin antibodies. As a result, immunohistochemical staining was positive for S-100 and was weakly positive for osteopontin antibodies. In the presented report, a case of hibernoma in a cat was described with the clinical, histopathological, immunohistochemical findings and treatment procedure.

Bir Kedide Abdominal Hibernoma: Olgu Sunumu

Hibernoma, kış uykusunda ve kış uykusunda olmayan memelilerde bulunan, çok nadir görülen, iyi huylu bir kahverengi yağ dokusu tümörüdür. Bugüne kadar farelerde, köpeklerde ve insanlarda bildiren raporlar bulunmaktadır. Bu olgu sunumunda; on üç yaşında, kısır, dişi bir Siyam kedisi bağırsak motilite bozukluğuna yönelik muayene edildi. Kontrast madde verilmesinden 72 saat sonra radyografilerde colon descendens’te lokal obstruksiyon gözlendi. Abdominal organların incelenmesi için diyagnostik laparotomi yapıldı. Karın duvarında, colon descendens ile mezenteryum adezyonuyla karakterize 1 cm çapında bir kitle gözlendi ve kitle tamamen çıkarıldı. Ameliyat sonrası tedavi; intestinal diyet, metoklopramid ve enrofloksasin uygulamasıyla sürdürüldü. Kitlenin histopatolojik incelemesinde; kitleye kahverengi yağ dokusunun iyi huylu tümörü olan Hibernoma tanısı konuldu. Tümörün orijinini ve biyolojik davranışını değerlendirebilmek için S-100 ve osteopontin antikorları kullanılarak, immünohistokimyasal analizler yapıldı. Sonuç olarak, immünohistokimyasal boyamalarda tümör dokusu S-100 için kuvvetli pozitifken, osteopontin’e karşı çok zayıf pozitif yanıt verdi. Bu yazıda, bir kedide saptadığımız hibernoma klinik, histopatolojik, immünohistokimyasal bulgular ve tedavi prosedürü birlikte sunulmuştur.

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