Mustafa CAN GÜLER, Ayhan TANYELİ, ERSEN ERASLAN, Fazile Nur EKİNCİ AKDEMİR, ÖMER TOPDAĞI, Tuncer NACAR

Higenamine Decreased Oxidative Kidney Damage Induced By Ischemia Reperfusion in Rats

The aim of this research is to determine protective effects of higenamine on kidney tissue injury caused by ischemia reperfusion. In this study, 24 Sprague Dawley female rats were divided into 3 groups. The groups were designed as follows; control, ischemia reperfusion, and ischemia reperfusion + higenamine. Some oxidant, antioxidant and inflammatory parameters were evaluated in kidney tissues at the end of the experimental procedure. It was confirmed that the oxidant and inflammatory parameters of kidney tissue increased and antioxidant parameters decreased in ischemia reperfusion group compared to control group. Antioxidant parameters increased while oxidant and inflammatory parameters decreased in the ischemia reperfusion + higenamine group compared to ischemia reperfusion group. These results have demonstrated that higenamine administration as single dose is effective against oxidative kidney damage originating from ischemia reperfusion.

Higenamin Ratlarda İskemi Reperfüzyonunun Neden Olduğu Oksidatif Böbrek Hasarını Azaltır

Bu araştırmanın amacı, higenaminin, iskemi reperfüzyonunun neden olduğu böbrek dokusu hasarı üzerine koruyucu etkilerini belirlemektir. Bu araştırmada 24 adet Sprague Dawley dişi sıçan üç gruba ayrıldı. Bu çalışmanın grupları aşağıdaki şekilde tasarlanmıştır; kontrol, iskemi reperfüzyon ve iskemi reperfüzyon + higenamin grupları. Deney sonunda elde edilen böbrek dokularındaki bazı oksidan, antioksidan ve inflamatuvar parametreler değerlendirildi. İskemi reperfüzyon grubu kontrol grubu ile kıyaslandığında, böbrek dokusundaki oksidan ve inflamatuvar parametrelerin arttığı fakat antioksidan parametrelerin azaldığı belirlendi. Tedavi grubu (iskemi reperfüzyon + higenamin) yalnızca iskemi reperfüzyon grubu ile kıyaslandığında antioksidan parametreler artarken, oksidan ve inflamatuvar parametreler azaldı. Bu sonuçlar, tek doz higenamin uygulamasının, iskemi reperfüzyon kaynaklı oksidatif böbrek hasarına karşı etkili olduğunu göstermiştir.

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1. Mole DJ, Olabi B, Robinson V, Garden OJ, Parks RW: Incidence of individual organ dysfunction in fatal acute pancreatitis: Analysis of 1024 death records. HPB, 11 (2): 166-170, 2009. DOI: 10.1111/j.1477- 2574.2009.00038.x

2. Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW: Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol, 16 (11): 3365-3370, 2005. DOI: 10.1681/ asn.2004090740

3. Deng Y, Yuan J, Chi R, Ye H, Zhou D, Wang S, Mai C, Nie Z, Wang L, Zhai Y, Gao L, Zhang D, Hu L, Deng Y, Chen C: The Incidence, risk factors and outcomes of postoperative acute kidney injury in neurosurgical critically ill patients. Sci Rep, 7:4245, 2017. DOI: 10.1038/s41598-017- 04627-3

4. Deng Y, Chi R, Chen S, Ye H, Yuan J, Wang L, Zhai Y, Gao L, Zhang D, Hu L, Lv B, Long Y, Sun C, Yang X, Zou X, Chen C: Evaluation of clinically available renal biomarkers in critically ill adults: A prospective multicenter observational study. Crit Care, 21:46, 2017. DOI: 10.1186/s13054-017- 1626-0

5. Negi S, Koreeda D, Kobayashi S, Yano T, Tatsuta K, Mima T, Shigematsu T, Ohya M: Acute kidney injury: Epidemiology, outcomes, complications, and therapeutic strategies. Semin Dial, 31 (5): 519-527, 2018. DOI: 10.1111/sdi.12705

6. Chen H, Xing B, Liu X, Zhan B, Zhou J, Zhu H, Chen Z: Similarities between ozone oxidative preconditioning and ischemic preconditioning in renal ischemia/reperfusion injury. Arch Med Res, 39 (2): 169-178, 2008. DOI: 10.1016/j.arcmed.2007.09.005

7. Kim J, Jang HS, Park KM: Reactive oxygen species generated by renal ischemia and reperfusion trigger protection against subsequent renal ischemia and reperfusion injury in mice. Am J Physiol Renal Physiol, 298 (1): F158-F166, 2010. DOI: 10.1152/ajprenal.00474.2009

8. Shanley PF, Rosen MD, Brezis M, Silva P, Epstein FH, Rosen S: Topography of focal proximal tubular necrosis after ischemia with reflow in the rat kidney. Am J Pathol, 122 (3): 462-468, 1986.

9. Kaleli B, Aktan E, Gezer S, Kirkali G: Reperfusion injury after detorsion of unilateral ovarian torsion in rabbits. Eur J Obstet Gynecol Reprod Biol, 110 (1): 99-101, 2003.

10. Del Rio D, Stewart AJ, Pellegrini N: A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis, 15 (4): 316-328, 2005. DOI: 10.1016/j. numecd.2005.05.003

11. Linas SL, Shanley PF, Whittenburg D, Berger E, Repine JE: Neutrophils accentuate ischemia-reperfusion injury in isolated perfused rat kidneys. Am J Physiol, 255 (4): F728-F735, 1988. DOI: 10.1152/ ajprenal.1988.255.4.F728

12. Wang L, Shan Y, Chen L, Lin B, Xiong X, Lin L, Jin L: Colchicine protects rat skeletal muscle from ischemia/reperfusion injury by suppressing oxidative stress and inflammation. Iran J Basic Med Sci, 19 (6): 670-675, 2016.

13. Hashmp SF, Sattar MZA, Rathore HA, Ahmadi A, Johns EJ: A critical review on pharmacological significance of hydrogen sulfide (H2S) on NFκB concentration and icam-1 expression in renal ischemia reperfusion injury. Acta Pol Pharm, 74 (3): 747-752, 2017.

14. Peng J, Ren X, Lan T, Chen Y, Shao Z, Yang C: Renoprotective effects of ursolic acid on ischemia/reperfusioninduced acute kidney injury through oxidative stress, inflammation and the inhibition of STAT3 and NFkappaB activities. Mol Med Rep, 14 (4): 3397-3402, 2016. DOI: 10.3892/ mmr.2016.5654

15. Schrier RW, Wang W, Poole B, Mitra A: Acute renal failure: definitions, diagnosis, pathogenesis, and therapy. J Clin Invest, 114 (1): 5-14, 2004. DOI: 10.1172/JCI22353

16.Andreucci M, Faga T, Pisani A, Sabbatini M, Michael A: Acute kidney injury by radiographic contrast media: Pathogenesis and prevention. Biomed Res Int, 2014:362725, 2014. DOI: 10.1155/2014/362725

17. Zhang N, Lian Z, Peng X, Li Z, Zhu H: Applications of higenamine in pharmacology and medicine. J Ethnopharmacol, 196, 242-252, 2017. DOI: 10.1016/j.jep.2016.12.033

18. Singhuber J, Zhu M, Prinz S, Kopp B: Aconitum in traditional Chinese medicine: A valuable drug or an unpredictable risk? J Ethnopharmacol, 126 (1): 18-30, 2009. DOI: 10.1016/j.jep.2009.07.031

19. Kosuge T, Yokota M: Studies on cardiac principle of aconite root. Chem Pharm Bull (Tokyo), 24 (1): 176-178, 1976. DOI: 10.1248/cpb.24.176

20. Ohkawa H, Ohishi N, Yagi K: Assay for lipid peroxides in animaltissues by thiobarbituric acid reaction. Anal Biochem, 95 (2): 351-358, 1979.

21. Sun Y, Oberley LW, Li Y: A Simple method for clinical assay of superoxide-dismutase. Clin Chem, 34 (3): 497-500, 1988.

22. Bradley PP, Priebat DA, Christensen RD, Rothstein G: Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker. J Invest Dermatol, 78 (3): 206-209, 1982.

23. Eraslan E, Tanyeli A, Polat E, Yetim Z: Evodiamine alleviates kidney ischemia reperfusion injury in rats: A biochemical and histopathological study. J Cell Biochem, 120 (10): 17159-17166, 2019. DOI: 10.1002 /jcb.28976

24. Zuk A, Bonventre JV: Acute kidney injury. Annu Rev Med, 67, 293-307, 2016. DOI: 10.1146/annurev-med-050214-013407

25. Lameire N, Van Biesen W, Vanholder R: The changing epidemiology of acute renal failure. Nat Clin Pract Nephrol, 2, 364-377, 2006. DOI: 10.1038/ncpneph0218

26. Oliveira RC, Brito MV, Ribeiro RFJ, Oliveira LO, Monteiro AM, Brandao FM, Cavalcante LC, Gouveia EH, Henriques HY: Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats. Acta Cir Bras, 32 (3): 229-235, 2017. DOI: 10.1590/s0102-865020170030000007

27. Sheashaa H, Lotfy A, Elhusseini F, Aziz AA, Baiomy A, Awad S, Alsayed A, El-Gilany AH, Saad MA, Mahmoud K, Zahran F, Salem DA, Sarhan A, Ghaffar HA, Sobh M: Protective effect of adiposederived mesenchymal stem cells against acute kidney injury induced by ischemia-reperfusion in Sprague-Dawley rats. Exp Ther Med, 11 (5): 1573- 1580, 2016. DOI: 10.3892/etm.2016.3109

28. Noiri E, Nakao A, Uchida K, Tsukahara H, Ohno M, Fujita T, Brodsky S, Goligorsky MS: Oxidative and nitrosative stress in acute renal ischemia. Am J Physiol Renal Physiol, 281 (5): F948-F957, 2001.

29. Aragno M, Cutrin JC, Mastrocola R, Perrelli MG, Restivo F, Poli G, Danni O, Boccuzzi G: Oxidative stress and kidney dysfunction due to ischemia/reperfusion in rat: Attenuation by dehydroepiandrosterone. Kidney Int, 64 (3): 836-843, 2003. DOI: 10.1046/j.1523-1755.2003.00152.x

30. Sedaghat Z, Kadkhodaee M, Seifi B, Salehi E, Najafi A, Dargahi L: Remote preconditioning reduces oxidative stress, downregulates cyclooxygenase-2 expression and attenuates ischaemia-reperfusion-induced acute kidney injury. Clin Exp Pharmacol Physiol, 40 (2): 97-103, 2013. DOI: 10.1111/1440-1681.12044

31. Kusano C, Ferrari C: Total antioxidant capacity: A biomarker in biomedical and nutritional studies. J Cell Mol Biol 7, 1-15, 2008.

32. Keith ES, Powers JJ: Effect of phenolic acids and esters on respiration and reproduction of bacteria in urine. Appl Microbiol, 13, 308-313, 1965.

33. Vaghasiya J, Sheth N, Bhalodia Y, Manek R: Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes. Regul Pept, 166 (1-3): 48-54, 2011. DOI: 10.1016/j.regpep.2010.08.007

34. Molitoris BA, Sutton TA: Endothelial injury and dysfunction: Role in the extension phase of acute renal failure. Kidney Int, 66 (2): 496-499, 2004. DOI: 10.1111/j.1523-1755.2004.761_5.x

35. Erdogan H, Fadillioglu E, Yagmurca M, Ucar M, Irmak MK: Protein oxidation and lipid peroxidation after renal ischemia-reperfusion injury: Protective effects of erdosteine and N-acetylcysteine. Urol Res, 34 (1): 41- 46, 2006. DOI: 10.1007/s00240-005-0031-3

36. Wang F, Yu G, Liu SY, Li JB, Wang JF, Bo LL, Qian LR, Sun XJ, Deng XM: Hydrogen-rich saline protects against renal ischemia/reperfusion injury in rats. J Surg Res, 167 (2): e339-e344, 2011. DOI: 10.1016/j.jss. 2010.11.005

37. Shen X, Hu B, Xu G, Chen F, Ma R, Zhang N, Liu J, Ma X, Zhu J, Wu Y, Shen R: Activation of Nrf2/HO-1 pathway by glycogen synthase kinase3β ınhibition attenuates renal ischemia/reperfusion ınjury in diabetic rats. Kidney Blood Press Res, 42 (2): 369-378, 2017. DOI: 10.1159/000477947

38. Zhang Y, Hu F, Wen J, Wei X, Zeng Y, Sun Y, Luo S, Sun L: Effects of sevoflurane on NF-кB and TNF-α expression in renal ischemia-reperfusion diabetic rats. Inflamm Res, 66 (10): 901-910, 2017. DOI: 10.1007/s00011- 017-1071-1

39. Munoz M, Lopez-Oliva ME, Pinilla E, Martinez MP, Sanchez A, Rodriguez C, Garcia-Sacristan A, Hernandez M, Rivera L, Prieto D: CYP epoxygenase-derived H2O2 is involved in the endothelium-derived hyperpolarization (EDH) and relaxation of intrarenal arteries. Free Radic Biol Med, 106, 168-183, 2017. DOI: 10.1016/j.freeradbiomed. 2017.02.031

40. Huang R, Zhou Q, Veeraragoo P, Yu H, Xiao Z: Notch2/Hes-1 pathway plays an important role in renal ischemia and reperfusion injuryassociated inflammation and apoptosis and the γ-secretase inhibitor DAPT has a nephroprotective effect. Ren Fail, 33 (2): 207-216, 2011. DOI: 10.3109/0886022x.2011.553979

41. Xing B, Chen H, Wang L, Weng X, Chen Z, Li X: Ozone oxidative preconditioning protects the rat kidney from reperfusion injury via modulation of the TLR4-NF-κB pathway. Acta Cir Bras, 30 (1): 60-66, 2015. DOI: 10.1590/s0102-86502015001000008

42. Dinarello CA: Biologic basis for interleukin-1 in disease. Blood, 87 (6): 2095-2147, 1996.

43. Bai M, Zhang L, Fu B, Bai J, Zhang Y, Cai G, Bai X, Feng Z, Sun S, Chen X: IL-17A improves the efficacy of mesenchymal stem cells in ischemic-reperfusion renal injury by increasing Treg percentages by the COX-2/PGE2 pathway. Kidney Int, 93 (4): 814-825, 2018. DOI: 10.1016/j. kint.2017.08.030

44. Nishikawa H, Taniguchi Y, Matsumoto T, Arima N, Masaki M, Shimamura Y, Inoue K, Horino T, Fujimoto S, Ohko K, Komatsu T, Udaka K, Sano S, Terada Y: Knockout of the interleukin-36 receptor protects against renal ischemia-reperfusion injury by reduction of proinflammatory cytokines. Kidney Int, 93 (3): 599-614, 2018. DOI: 10.1016/j.kint.2017.09.017

45. Wang X, Li X, Jingfen W, Fei D, Mei P: Higenamine alleviates cerebral ischemia-reperfusion injury in rats. Front Biosci, 24, 859-869, 2019.

46. Zhang Y, Zhang J, Wu C, Guo S, Su J, Zhao W, Xing H: Higenamine protects neuronal cells from oxygen-glucose deprivation/reoxygenationinduced injury. J Cell Biochem, 120 (3): 3757-3764, 2019. DOI: 10.1002/ jcb.27656

47.Duan W, Chen J, Wu Y, Zhang Y, Xu Y: Protective effect of higenamine ameliorates collagen-induced arthritis through heme oxygenase-1 and PI3K/Akt/Nrf-2 signaling pathways. Exp Ther Med, 12 (5): 3107-3112, 2016. DOI: 10.3892/etm.2016.3730