Utku BAKIREL, Alev A. KAYMAZ, Cevdet TOSUN, Ercan KARABULUT, Hüseyin TAN, Murat ASLAN, Erman OR

Strongylus türleri ile enfekte genç ve erişkin atlarda doramectin kullanımının klinik ve hematolojik olarak değerlendirilmesi

Bu çalışma; strongylus türleri ile doğal enfekte genç ve erişkin atlarda İ.M. doramectinin uygulanmasını takiben klinik bulgularda ve bazı hematolojik parametrelerde her-hangi bir değişikliğin olup olmadığının belirlenmesi amacıyla yapıldı.Yaşları 1-5 arasında değişen 13'ü erkek, 22'si dişi (Grup-I, ri= 35) ve 6-21 arasında değişen 8'i erkek 27'si dişi (Grup-II, n=35) toplam 70 adet at kullanıldı. Doramectin (0.2 mg/kg İ.M., Dectomax ® Pfizer) uygulamasından önce ve 10 hafta süreyle her hafta bütün atların klinik muayeneleri yapıldı ve gram dışkıdaki strongylus yumurta sayıları McMaster tekniği ile belirlen-di. Her iki gruptan rast gele seçilen 10'ar adet atın tedavi öncesi ve sonrası 6., 12. ve 24. saatlerde WBC ve PCV değerleri ile serum AST, ALT, ALP, GOT, LDH, CK, T.protein, T.bilirubin, kreatirn'n, üre, kolesterol ve trigliserid düzeyleri ölçüldü. Bu parametreler her hafta olmak üzere l O hafta süreyle belirlendi.Çalışma esnasında Doramectin enjeksiyonu sonrası atlarda lokal ve sistemik bir reaksi-yonun oluşmadığı görüldü. Tedaviden 10 hafta sonra dışkıdaki strongylus yumurta sayısındaki azalma Grup-I'de %96.7 ve Grup-II'de ise %97.9 olarak saptandı (p

Clinical and haematological evaluation of use of doramectin in infected young and adult horses with Strongylus spp.

In this study was aimed to determine weather a change in clinical findings and some haematological parameter after using doramectin İ.M. (0.2 mg/kg) in naturally infected young and adult horses with srongylus spp.Seventy horse of either genders (21 males, 49 females) and varied ages (between 1-21) were used in this study. All horses were divided in this groups (22 males, 13 females, ages varied between 1-5 years) and group-II (27 male, 8 females, 6-21 ages varied between years). Before using doramectin (0.2mg/kg İ.M., Dectomax â Pfizer) treatment all horses were clinically exam-ined for 10 weeks and strongylus spp. egg counts were determined in gram faecal with Mcmaster methods.Before and after the therapy WBC, PCV, serum AST, ALT, ALP, GOT, LDH, CK, T.protein, T.bilirubin, creatinin, urea, cholesterol and triglyserid levels were measured at 6., 12. and 24. hours in 10 horses randomised from each group. These parameters were determined every week for ten weeks. During the study, local or systemic reactions were not observed after doramectin injection.After ten weeks of treatment it was observed that efficacy of doramectin against strongy-lus eggs were decreased the ratio of 96.7 % in group-I and of 97.9 % in group-II (pO.OOl). There was no change in WBC, PCV, serum AST, ALT, ALP, GOT, CK, T. protein, T. bilimbin, creatinin, urea, cholesterol and triglyserid levels. Serum LDH levels were increased significantly at 6 and 12 hours in each groups (p

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