Kalp Damar Cerrahisine Bağlı Akut Böbrek Yaralanması

Kardiyopulmoner baypas (KPB), bir ekstrakorporeal dolaşım modeli olup esas olarak bir pompa, rezervuar ve oksijeneratörden oluşur. KPB’ın başlangıcında kan hastadan bu endotelyal yüzey içermeyen ekstrakorporeal dolaşıma katılarak hastanın genotipi, peroperatif parametreler ve patolojinin kompleksitesine göre kalp cerrahisi sonrasında değişik derecelerde gelişen ve kanın hücresel, hücre dışı veya humoral bileşenleri tarafından yönetilen inflamatuvar süreci başlatır. Kalp ameliyatı geçiren hastalar arasında akut böbrek hasarı oluşumu kötü prognoz ve mortalite artışı ile ilişkili görünmektedir. Akut böbrek hasarı (ABH), yoğun bakım hastalarında sık karşılaşılan mortalite ve morbiditeyi arttırarak klinik seyri olumsuz yönde etkileyen bir tablodur.

Anahtar Kelimeler:

cardiopulmonary bypass, acute kidney injury, dialysis

ACUTE KIDNEY INJURY DUE TO CARDIOVASCULAR SURGERY

Cardiopulmonary bypass (CPB) is an extracorporeal circulatory model consisting essentially of a pump, reservoir and oxygenator. At the beginning of CPB, blood of the patient flows into the extracorporeal circulation, which does not contain the endothelial surface, from the patient and initiates the inflammatory process, that is developed by the cellular, extracellular or humoral components of the blood and this process varies according to the patient's genotype, peroperative parameters and complexity of the pathology. Acute renal injury among patients undergoing cardiac surgery appears to be associated with poor prognosis and increased mortality. Acute kidney injury (AKI) is a condition that increases the common mortality and morbidity in intensive care unit (ICU) patients and adversely affects the clinical course.

Keywords:

Kardiyopulmoner baypas, akut böbrek hasarı,

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