Ekrem YETER, Nazif AYGÜL, Mehmet KAYRAK, Mehmet TOKAÇ, Hasan GÖK

Revaskülarizasyon sonrası restenozun efor testi ile değerlendirilmesi ve restenoz için bir risk olarak fibrinojen ve C-reaktif proteinin değeri

Amaç: Biz bu çalışmada revaskülarize edilen hastalarda restenoz tespitinde egzersiz testinin önemini ve restenoz için bir risk olarak fibrinojen ve CRP’nin değerini araştırdık. Yöntem: Çalışmaya Selçuk Üniversitesi Meram Tıp Fakültesi Kardiyoloji Anabilim Dalında 2001-2002 yılları arasında revaskülarize edilen 100 hasta alındı. 20 hasta çeşitli nedenlerden dolayı çalışma dışı bırakıldı. Geriye kalan 80 hasta çalışmaya dahil edildi. Tüm hastalar egzersiz stres testi (EST), C reaktif protein (CRP), fibrinojen ve diğer biokimyasal ölçümler ile 6. ayda kontrol edildi. Elli hastaya kontrol koroner anjiyografi yapıldı. Koroner anjiyografisi yapılıp restenoz tespit edilmiş olanlar grup 1 ve koroner anjiyografi sonrası restenoz tespit edilmeyenler ile maksimal efor testi negatif olup asemptomatik olan olgular grup 2 olarak ayrıldı. Bulgular: Fibrinojen ve CRP değerleri arasında grup 1’de, grup 2’ e göre anlamlı yükseklik belirlendi. Grup 1’de hastaların % 78’ inde efor testi pozitif iken; grup 2’de hastaların % 21’inde pozitif olarak bulundu (p

Anahtar Kelimeler:

C-reaktif protein, Egzersiz testi, Fibrinojen, Koroner anjiyografi, Koroner restenoz

Evaluation of restenosis by the exercise testing in revascularized patients and value of C-reaktive protein and fibrinojen as a risk for restenosis

Objective: This study was designed to investigate; (i) the importance of exercise stress testing (EST) for detection of restenosis, (ii) value of C-reactive protein (CRP) and fibrinogen as a risk factor for restenosis in the revascularized patients. Methods: One hundred revascularized patients were enrolled to the study but 20 of the subjects were excluded from the study due to the various reasons that may affect the results of study. All patients were reevaluated 6 month after revascularization by the EST, CRP, fibrinogen and blood parameters. Fifty patients were underwent control coronary angiography. Patients were divided into two groups according to restenosis. Patients with restenosis in control coronary angiography were assigned as group 1, and patients without restenosis and having maximal negative EST were assigned as group 2. Results: Fibrinogen and CRP values were significantly high in group 1 than group 2 (p<0.05). The sensitivity, specificity of the EST was 78%, and 79% respectively. Conclusion: Although other new diagnostic methods, exercise testing is also an important test for detection of restenosis after revascularization. Sensitivity of EST may be increased with other diagnostic tests. C-reactive protein and fibrinogen may help physician in detection of risk of restenosis in revascularized patients.

Keywords:

C-Reactive Protein, Exercise Test, Fibrinogen, Coronary Angiography, Coronary Restenosis,

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