İnflamatuar medyatörlere toplu bir bakış

Amaç: Bu derlemede inflamasyonun kimyasal medyatörleri olan vazoaktif aminler, plazma proteazları, araşidonik asid metabolitleri, lökosit ürünleri, trombosit aktive edici faktör, sitokinler, büyüme faktörleri, nitrik oksid ve son yıllarda üzerinde çalışılan yeni medyatörler olan P maddesi, kalpainler, hem oksigenaz-1 ve yüksek göçlü grup-1 protein hakkında bilgi verilecektir. Ana Bulgular: İnflamasyonun vasküler ve hücresel yanıtları, plazma hücrelerinden çıkan ve inflamatuar bir uyaranla meydana gelen kimyasal faktörlerle ortaya çıkmaktadır. Ağrı, ateş, ödem, kızarıklık, fonksiyon kaybı ve skar oluşumu gibi akut ve kronik inflamatuar yanıt belirtileri, organizmayı hücre incinmesine neden olan etkenlerden ve buna bağlı oluşan nekrotik hücre ve dokulardan temizleyerek tamir eder ve olayı sınırlar. Sonuç: Kimyasal medyatörlerin aracılık ettiği inflamasyonun koruyucu yanıtları olmaksızın yaşam sürdürülemez. Aksi takdirde, infeksiyonlar azalacak, yanıklar iyileşmeyecek, yaralar açık ve ağrılı olacaktır. Bununla birlikte, artmış inflamatuar yanıt, aşırı duyarlılık ve postinflamatuar reaksiyonlarla komplikasyonlara neden olabilir.

Anahtar Kelimeler:

Nitrik oksit, Kalpain, Araşidonik asit, Sitokinler, Substans P

A global view to inflammatory mediators

Objective: In this review, it has been given information about chemical mediators of inflammations such as vasoactive amines, plasma proteases, arachidonic acid metabolites, leukocyte products, trombocyte activating factor, cytokines, growth factors, nitric oxide, substance P, calpains, hem oxigenases, high mobility grup box-1 protein. Main Findings: Vascular and cellular responses of inflammation arise from chemical mediators, which can be released by plasma cells through an inflammatory stimulus. Acute and chronic inflammatory response symptoms such as pain, fever, edema, rubor, function leasing and scar formation repair by removing necrotic cells and tissues resulted from the damaged cell and, therefore limit the incident. Conclusion: Human being does not live long without these defense mechanism of inflammation. Adversely, infections are going to reduce, but in addition to, burns not heal, wounds be opened, painful and be supurative. However, increased inflammatory response results in complications included hypersensitivity and postinflammatory reactions.

Keywords:

Nitric Oxide, Calpain, Arachidonic Acid, Cytokines, Substance P,

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