Arif KURTDEDE, Erman GÜLENDAĞ, Erdal KARA, Efe KURTDEDE, Mehmet BAġER

Sütçü Ġneklerde Doğum Sonrası Vücut Kondüsyon Skoru, Kolostral IgG Konsantrasyonu, Karaciğer Lipid Metabolizması ve Oksidatif Stres Arasındaki IliĢkiler

Bu çalışmada, vücul kondüsyon skorları (VKS) ≤3.5 ve >3.5 olan süt ineklerinde postpartum VKS ile kolostral IgG, lipid metabolizması, karaciğer fonksiyonları ve oksidatif stres parametreleri arasındaki ilişkilerin değerlendirilmesi amaçlandı. Bu araştırma, bir süt çiftliğinde iki veya daha fazla doğum yapmış, aynı ırktan, 3-5 yaşlarında 60 süt ineğini içermektedir. İneklerin VKS değişikliklerinin kuru dönemden buzağılamaya kadar 3.5 olan 30 inekte ortalama VKS seviyesi 3.96±0.14 ve ortalama serum BHBA seviyesi 0.38±0.07 idi. VKS’si >3.5 olan ineklerde belirlenen değerlerle karşılaştırıldığında; VKS’si ≤3.5 olan ineklerde serum non-ester yağ asidi (NEFA), yüksek yoğunluklu lipoprotein (HDL), paraoksanaz-1 (PON-1) ve malondialdehit (MDA) düzeyleri anlamlı olarak daha düşüktü ve trigliserit, albümin, SOD ve kolostral IgG düzeyleri anlamlı olarak yüksekti. Sonuç olarak, süt ineklerinde lipid metabolizmasının ve oksidatif stresin daha iyi yönetimi ve daha yüksek kolostral IgG seviyesinin sağlanabilmesi için, ineklerdeki VKS değişikliğinin kuru dönemden doğuma kadarki dönemde

Relationships between the Postpartum Body Condition Score, Colostral IgG Content, Liver Lipid Metabolism and Oxidative Stress in Dairy Cows

his study aimed to evaluate the relationships between the postpartum body condition score (BCS) and colostral IgG, lipid metabolism, liver functions and oxidative stress parameters in dairy cows with BCSs of ≤3.5 and >3.5. This investigation included 60 dairy cows of the same breed, that were 3-5 years old and had given two or more births in a dairy farm. Care was taken to ensure that the BCS changes of the cows were 3.5 within 24 hours of birth, the mean BCS level was 3.96±0.14 and the mean serum BHBA level was 0.38±0.07. Compared to the values determined in cows with a BCS >3.5, serum non-esterified fatty acids (NEFA), high-density lipoprotein (HDL), paraoxonase-1 (PON-1) and malondialdehyde (MDA) levels were significantly lower, and triglyceride, albumin, SOD and colostral IgG levels were significantly higher in cows with a BCS of ≤3.5. It was concluded that a BCS change of

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. Serin, G. Sütçü ineklerde beden kondüsyon skorunun reprodüktif performans üzerine etkisi. Kafkas Üniv Vet Fak Derg 2004; 10: 221-225.
2. LeBlanc SJ. Monitoring metabolic health of dairy cattle in the transition period. J Reprod Dev 2010; 56: 29-35.
3. LeBlanc SJ. Interactions of metabolism, inflammation, and reproductive tract health in the postpartum period in dairy cattle. Reprod Dom Anim 2012; 47: 18-30.
4. Ferguson JD, Galligan DT, Thomsen N. Principal descriptors of body condition score in Holstein cows. J Dairy Sci 1994; 77: 2695-2703.
5. Roche JR, Friggens NC, Kay JK, et al. Invited review: Body condition score and its association with dairy cow productivity, health, and welfare. J Dairy Sci 2009; 92: 5769-5801.
6. Varışlı Ö. Tekin N. Holştayn ırkı ineklerde vücut kondisyon skorunun fertilite ve bazı reprodüktif parametrelere etkisi. Ankara Üniv Vet Fak Derg 2011; 58: 111-115.
7. Mulligan FJ, O‟Grady L, Rice DA, Doherty ML. A heard helth approach to dairy cow nutrition and production diseases of the transition cow. Anim Reprod Sci 2006; 96: 331-353.
8. Conneely M, Berry DP, Sayers R, et al. Factors associated with the concentration of immunoglobulin G in the colostrum of dairy cows. Animal 2013; 11: 1824-1832.
9. Grummer RR. Etiology of lipid-related metabolic disorders in periparturient dairy cows. J Dairy Sci 1993; 76: 3882- 3896.
10. Kessler EC, Gross JJ, Bruchmaier, RM, Albrech C. Cholesterol metabolism, transport, and hepatic regulation in dairy cows during transition and early lactation. J Dairy Sci 2014; 97: 5481-5490.
11. Mazur A, Rayssiquier Y. Lipoprotein profile of the lactating cow. Ann Rech Vet 1988; 19: 53-58.
12. Rodriguez-Jimenez S, Haerr KJ, Trevisi E, et al. Prepartal standing behavior as a parameter for early detection of postpartal subclinical ketosis associated with inflammation and liver function biomarkers in peripartal dairy cows. J Dairy Sci 2018; 9: 8224-8235.
13. Gonzalez FD, Muino R, Pereira V, Campos R, Benedito JL. Relationship among blood indicators of lipomobilization and hepatic function during early lactation in high-yielding dairy cows. J Vet Sci 2011; 12: 251-255.
14. Marutsova VJ, Marutsov PD, Binev RG. Evaluation of some blood liver parameters in cows with subclinical and clinical ketosis. Bulgarian Journal of Veterinary Medicine 2019; 22: 314-321.
15. Bernabucci U, Ronchi B, Lacetera N, Nardone A. Influence of body condition score on relationships between metabolic status and oxidative stress in periparturient dairy cows. J Dairy Sci 2005; 88: 2017- 2026.
16. Sordillo LM, O‘Boyle N, Gandy JC, Corl CM. Hamilton, E. Shifts in thioredoxin reductase activity and oxidant status in mononuclear cells obtained from transition dairy cattle. J Dairy Sci 2007; 90: 1186-1192.
17. Pigeolet E, Corbisier P, Houbion A, et al. Glutathione peroxidase, superoxide dismutase, and catalase inactivation by peroxides and oxygen derived free radicals. Mech Ageing Dev 1990; 51: 283-297.
18. Trevisi E, Amadori M, Bakudila AM, Bertoni G. Metabolic changes in dairy cows induced by oral, low-dose interferon-alpha treatment. J Anim Sci 2009; 87: 3020- 3029.
19. Bernabucci U, Ronchi B, Lacetera N, Nardone A. Markers of oxidative status in plasma and erythrocytes of transition airy cows during hot season. J Dairy Sci 2002; 85: 2173- 2179.
20. Castillo C, Hernández J, Bravo A, et al. Oxidative status during late pregnancy and early lactation in dairy cows. The Veterinary Journal 2005; 169: 286-292.
21. Agalakova NI, Gusev GP. Molecular mechanisms of cytotoxicity and apoptosis induced by inorganic fluoride. ISRN Cell Biol 2012; 1-16.
22. Aviram M, Rosenblat M, Bisgaier CL, et al. Paraoxonase inhibits high-density lipoprotein oxidation and preserves its function. J Clin Investig 1999; 101: 1581-1590.
23. Aviram M, Rosenblat M, Billecke S, et al. Human serum paraoxonase (PON1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants Free Radic Biol Med 1999; 26: 892-904.
24. Trevisi E, Grossi P, Bacchetti T, Ferretti G, Bertoni G. Variation factors of paraoxonase in blood and in HDL lipoproteins in dairy cow. Progr Nutr 2012; 14: 43-49.
25. Turk R, Juretic D, Geres D, et al. Influence of oxidative stress and metabolic adaptation on PON1 activity and MDA level in transition dairy cows. Anim Reprod Sci 2008; 108: 98-106.
26. Turk R, Juretic D, Geres D, et al. Serum paraoxonase activity and lipid parameters in the early postpartum period of dairy cows. Research in Veterinary Science 2004; 76: 57-61.
27. Turk R, Juretic D, Geres D, et al. Serum paraoxonase activity in dairy cows during pregnancy. Research in Veterinary Science 2005; 79: 15-18.
28. Çolakoğlu HE, Küplülü Ş. İnek ve düvelerde vücut kondisyon skoru değiģiminin postpartum döneme ve fertilite parametrelerine etkisi. Kocatepe Vet J 2016; 9: 146-158.
29. Zhao W, Chen X, Xiao J, et al. Prepartum body condition score affects milk yield, lipid metabolism, and oxidation status of Holstein cows. Asian-australas J Anim Sci 2019; 32: 1889-1896.
30. Pires JAA, Delavaud C, Faulconnier Y, Pomi, D, Chilliard Y. Effects of body condition score at calving on indicators of fat and protein mobilization of periparturient Holstein- Friesian cows. J Dairy Sci 2013; 96: 6423-6439.
31. Drackley JK. ADSA Foundation Scholar Award. Biology of dairy cows during the transition period: The final frontier. J Dairy Sci 1999; 82: 2259-2273.
32. Gheise EJN, Riasi A, Shahneh ZA, Celi P, Ghoreishi SM. Effect of pre-calving body condition score and previous lactation on BCS change, blood metabolites, oxidative stress and milk production in Holstein dairy cows. Ital J Anim Sci 2017; 16: 474-483.
33. Folnozic I, Turk R, Duricic D, et al. Influence of body condition on serum metabolic ındicators of lipid mobilization and oxidative stress in dairy cows during the transition period. Rep Domestic Anim 2015; 50: 910-917.
34. O'Boyle N, Corl CM, Gandy JC, Sordillo LM. Relationship of body condition score and oxidant stress to tumor necrosis factor expression in dairy cattle. Vet Immunol Immunopathol 2006; 113: 297-304.
35. Çolakoğlu HE, Yazlık MO, Kaya U, et al. Relationship between body condition score, blood metabolites and oxidative stress in transition period and reproductive performance of dairy cows. J Hellenic Vet Med Soc 2020; 71: 2041-2046.
36. Sevinç M, Başoğlu A, Birdane FM, Boydak M. Liver function in dairy cows with fatty liver. Rev Med Vet 2001; 152: 279-300.
37. Zhou Z, Loor JJ, Picciolli-Cappelli F, et al. Circulating amino acids in blood plasma during the peripartal period in dairy cows with different liver functionality index. J Dairy Sci 2016; 99: 2257-2267.
38. Ferguson JD, Galligan DT, Thomsen N. Principal descriptors of body condition score in Holstein cows. J Dairy Sci. 1994; 77: 2695-2703.
39. Vailati-Riboni M, Kanwal M, Bulgari O, et al. Body condition score and plane of nutrition prepartum affect adipose tissue transcriptome regulators of metabolism and inflammation in grazing dairy cows during the transition period. J Dairy Sci 2016; 99: 758-770.
40. Krajnicakova M, Kovac G, Kostecky M, et al. Selected clinic-biochemical parameters in the puerperal period of goats. B Vet I Pulawy 2003; 47: 177-182.
41. Amer HA. Effect of body condition score and lactation number on selected reproductive parameters in lactating dairy cows. Global Veterinaria 2008; 2: 130-137.
42. Jilek F, Pytloun P, Kubesova M, et al. Relationships among body condition score, milk yield and reproduction in Chech Fleckvieh cows. Czech J Anim Sci 2008; 53: 357-367.
43. Mulligan FJ, Doherty ML. Production diseases of the transition cow. The Veterinary Journal 2008; 176: 3-9.
44. Podpecan O, Zrimsek P, Mrkun J, et al. Tresholds of blood variables obtained by receiver operating characteristic analysis for indication of fat and glycogen content in the liver of postpartum dairy cows. Italian Journal of Animal Science 2020; 19: 303-309.
45. Turk RO, Podpecan J, Mrkun M, et al. Lipid mobilisation and oxidative stress as metabolic adaptation processes in dairy heifers during transition period. Anim Reprod Sci 2013; 141: 109-115.
46. Drackley JK, Overton TR, Douglas GN. Adaptations of glucose and long-chain fatty acid metabolism in liver of dairy cows during the periparturient period. J Dairy Sci 2001; 84: 100-E112.
47. Oetzel GR. Monitoring and testing dairy herds for metabolic disease. Vet Clin North Am Food Anim Pract 2004; 20: 651-674.
48. Shearer J, Mohammed H, Brenneman J, Tran T. Factors associated with concentrations of immunoglobulins in colostrum at the first milking post-calving. Prev Vet Med 1992; 14; 143-154.
49. Immler M, Failing K, Wehrend A, Donat K. Associations between the metabolic status of the cow and colostrum quality as determined by Brix refractometry. J Dairy Sci 2021; 104: 10131-10142.
50. Abdullahoğlu E, Duru S, Özlüer A, Filya İ. Factors affecting colostrum quality and calf passive transfer levels in Holstein cattle. Anim Sci Pap Rep 2019; 37: 29-39.
51. Soufleri A, Banos G, Panousis N, et al. Evaluation of Factors affecting colostrum quality and quantity in holstein dairy cattle. Animals 2021; 11: 1-14