Sistemik İnflamatuar Yanıt Sendromu ve Sepsis

Sistemik inflamatuar yanıt sendromu (SIRS), mikroorganizma ile kontamine veya kontamineolmayan etkenlerden dolayı vücudun hematolojik ve immünolojik yanıtlar verdiği olaylar bütünüdür.SIRS ile enfeksiyonun birlikte bulunması sepsistir. Enfeksiyöz ve enfeksiyöz olmayan nedenleretiyolojide önem arz eder. Mukozalarda hiperemi ve peteĢiyel kanama odakları, kapiller dolumzamanında uzama, diĢ etlerinde belirgin koyu renkte toksik çizginin belirmesi gözlenen yaygın klinikbulgulardır. Bu klinik bulgular dinamik ya da dinamik olmayan yanıt dizinlerini barındırmaktadır.Hematolojik profilde lökositoz/lökopeni, nötrofili/nötropeni, lenfopeni, anemi ve trombositopeniönemli sonuçlardır. Biyokimyasal profilde hiperglisemi/hipoglisemi, hipoalbuminemi vehiperbilirubinemi yaygın bulgulardır. Tanıda, anamnez, klinik bulgular, biyokimyasal biyobelirteçlerve hematolojik parametreler birlikte değerlendirilmelidir. Prognoz değerlendirilirken günlük tedaviyeverilen etkin yanıtın yorumlanması gerekir. Tedavide diyet, antibiyotik, immünoterapi, sıvı veelektrolit uygulamaları, semptomatik ve destekleyici tedaviler önemlidir.

Systemic Inflammatory Response Syndrome and Sepsis

Systemic inflammatory response syndrome (SIRS) is the set of events that the body gives hematologic and immunologic responses due to microbial contaminated and decontaminated reasons. It is sepsis that SIRS and infection co-exist. Infectious and non-infectious causes are important in etiology. Hyperemia and petechial bleeding foci, prolongation of capillary filling time, the presence of a distinctive dark toxic line on the gums is common clinical signs. These clinical symptoms include dynamic or non-dynamic response index. Hematologically, leukocytosis/leukopenia, neutrophilia/neutropenia, lymphopenia, anemia, and thrombocytopenia are important results. Hyperglycemia or hypoglycemia, hypoalbuminemia, and hyperbilirubinemia are common findings in the biochemical profile. For diagnosis clinical findings, anamnesis, serum biochemical parameters, serum bioindicators, and hemogram findings should be evaluated together. When evaluating prognosis in SIRS and sepsis, the effective response to daily treatment should be interpreted. In treatment, diet, antibiotics, immunotherapy, fluid and electrolyte applications, and symptomatic and supportive treatments are important.

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