Diyabet Oluşturulan Ratların Böbrek Dokusunda Oksidatif Stres ve Apoptozis Üzerine Perilil Alkolün Koruyucu Etkileri

Bu çalışmada diyabet oluşturulan ratların böbrek dokusunda oksidatif stres ve apoptozis üzerineperilil alkolün etkileri araştırılmıştır. Bu amaçla 40 adet rat eşit olarak rastgele 4 gruba ayrılmıştır.1.Grup (kontrol), 2. Grup (Diyabet; STZ 50 mg/kg i.p, tek doz), 3. Grup (Perilil Alkol; Perilil Alkol 50mg/kg/gün p.o, 7 gün), 4. Grup (Diyabet+Perilil Alkol; STZ 50 mg/kg i.p, tek doz+Perilil Alkol 50mg/kg/gün, p.o 7 gün). Çalışma sonunda böbrek dokusu örneklerinde bazı biyokimyasalparametreler malondialdehit (MDA), glutatyon (GSH), glutatyon peroksidaz (GSH.Px), katalaz(CAT) ve apoptotik indeks markerları olan Bax ve Bcl-2 seviyeleri Western blot analizleri ileölçülmüştür. Çalışma sonucunda diyabet oluşturulan grupta MDA seviyesi kontrol grubuna göreartmış (P

Protective Effects of Perilyl Alcohol on Oxidative Stress and Apoptosis in Kidney Tissues of Diabetic Rats

The aim of this study was to investigate the effects of perilyl alcohol on renal tissue oxidative stress and apoptosis in diabetic rats. For this purpose, 40 rats were divided into 4 groups with 10 rats per group. The experimental groups were Group 1 (control), Group 2 (Diabetes; STZ 50 mg/kg ip, Single Dose), Group 3 (Perilil Alcohol; Perilil Alcohol 50 mg/kg po, 7 days), and Group 4 (Diabetes+Perilil Alcohol; STZ 50 mg/kg ip, Single Dose+Perilyl Alcohol 50 mg/kg po 7 days). Biochemical parameters malondialdehyde (MDA), Glutathione (GSH), Glutathione Peroxidase (GSH.Px), Catalase (CAT) and Bax and Bcl-2 levels were measured at the end of the study. Results showed that MDA level increased in diabetic group compared to control group (P

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