Osman GÜLER, Halil ŞİMŞEK, Ayşe KILIÇ, Mine ERİŞİR, Fulya BENZER, Bülent TAŞDEMİR, Sema TEMİZER OZAN

Ornithobacterium rhinotracheale ile Enfekte Edilen Broylerlerde Lipid Peroksidasyon ve Bazı Antioksidanlar Üzerine Enrofloksasin ve Kafeik Asit Fenetil Ester'in Etkisi *

Bu araştırmada 4 haftalık 96 broyler civciv 8 gruba bölündü. I. Kontrol Grubu, II. Antibiyotik Grubu, III. Kafeik asit fenetil ester (KAFE) Grubu, IV. Antibiyotik+KAFE Grubu, V.Ornithobacterium rhinotracheale (ORT) Grubu, VI. ORT+Antibiyotik Grubu, VII. ORT+KAFE Grubu ve VIII. ORT+Antibiyotik+KAFE Grubu. ORT 3263/91 suşunu (serotip A) 3.8x108 CFU/mL içeren inokulum aerosol olarak verildi (Grup V-VIII). Gruplara antibiyotik ve KAFE uygulanmasına ORT verilmesinden sonraki 17. günde aynı zamanda başlatıldı. 6 gün süre ile enrofloksasin (10 mg/kg/gün) içme sularına katıldı (Grup II, IV, VI, VIII), KAFE (10 µmol/kg) i.p olarak uygulandı (Grup III, IV, VII, VIII). ORT enfeksiyonu sonucu akciğer dokusunda malondialdehit (MDA) düzeyi (P

The Effects of Enrofloxacin and Caffeic Acid Phenethyl Ester on Lipid Peroxidation and Some Antioxidants in Broilers Infected by Ornithobacterium rhinotracheale

In this study, 96 broiler chicks aged 4 weeks were divided into 8 groups. The groups were;I.Control, II.Antibiotic, III. caffeic acid phenethyl ester (CAPE), IV.Antibiotic+CAPE,V.Ornithobacterium rhinotracheale (ORT), VI.ORT+Antibiotic, VII.ORT+CAPE andVIII.ORT+Antibiotic+CAPE. An inoculum of the ORT 3263/91 strain containing 3.8x108 CFU/mLwas given as aerosol (Groups V-VIII). The administration of antibiotic and CAPE to the groups wasstarted at the same time on the 17th day after giving the ORT. Enrofloxacin (10 mg/kg/day) wasadded to drinking water (Groups II, IV, VI, VIII), CAPE (10 µmol/kg) was applied as i.p (Groups III,IV, VII, VIII) for 6 days. ORT infection increased malondialdehyde (MDA) level and superoxidedismutase (SOD) activity in lung tissue, MDA, glutathione (GSH) levels and glutathione peroxidaseactivity (GSH-Px) activity in trachea tissue, while decreased GSH-Px and catalase (CAT) activitiesin lung (P

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