Hasan GENÇOĞLU, Mehmet TUZCU, Cemal ORHAN, Zeynep TUZCU, Can Ali AĞCA, Kazım ŞAHİN

Diyabetik Sıçanlarda Taurinin Kalp Dokusu Antioksidan Düzeyleri ile NF-B ve Nrf2 Sinyal Yolakları Üzerine Etkisi

Taurin'in, nörotransmitterlerin modülasyonu ve antioksidasyon gibi önemli roller oynadığıkanıtlanmıştır. Bununla birlikte, diyabetle ilişkili kardiyak komplikasyonlarda taurinin olumlu etkisininmekanizması hakkında çok az şey bilinmektedir. Bu çalışmada, taurinin, sıçan kalp dokusu nükleerfaktör-kappa B (NF-κB p65) ve nükleer faktör eritroid 2 (Nrf2) sinyal yolağı üzerine etkileriaraştırıldı. Kırk adet (8 haftalık) erkek Wistar sıçan rasgele dört gruba ayrıldı. Gruplar; (i) Kontrolgrubu, (ii) taurin uygulanan grup, (iii) streptozotosin (STZ) enjekte edilip diyabet oluşturulan grup,(iv) STZ enjekte edilip diyabet oluşturulan ve diyabetin başlangıcından sonra 8 hafta süreyle taurin(%2 w/v oral yolla, içme suyuna katılarak) uygulanan grup olarak belirlendi. Diyabetik sıçanlardaartan kalp dokusu malondialdehit (MDA) seviyeleri, taurin takviyesi ile anlamlı şekilde azaldı(P

Effect of Taurine on Antioxidant Levels and NF-B ve Nrf2 Signaling Pathways in Heart Tissue of Diabetic Rats

Taurine has been proved to play important roles such as modulation of neurotransmitters and antioxidation. However, little is known about the mechanism of beneficial action of taurine in diabetes-associated cardiac complications. In the present study, we investigated the effects of taurine on nuclear factor-kappa B (NF-κB p65) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling pathway in heart tissue of rats. Forty (8-week-old) male Wistar rats were randomly divided into four groups; (i) control group, (ii) taurine treated group, (iii) diabetes induced with injection of streptozotocine (STZ) group, (iv) diabetic group treated with taurine (2% w/v, orally, in water) from the day on which STZ was injected or after the onset of diabetes for 8 weeks. The increased heart tissue malondialdehyde levels in diabetic rats were significantly decreased by taurine supplementation (P

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