Ratlarda Siklofosfamid ile Oluşturulmuş Hemorajik Sistitte Propolis ve Enginarın Koruyucu Etkileri

Çalışmada, siklofosfamid (CP) ile oluşturulmuş mesane toksisitesinde propolis ve enginarın etkileriincelenmiştir. Ratlar 6 gruba ayrılmıştır. Gruplar; kontrol grubu, propolis uygulanan grup (200mg/kg/gün gavaj, 7 gün), enginar uygulanan grup (1 g/kg/gün gavaj, 12 gün), CP uygulanan grup(150 mg/kg i.p. tek doz), CP+propolis uygulanan grup ve CP+enginar uygulanan grup şeklindeoluşturulmuştur. Propolis uygulamasına CP uygulamasından 2 gün önce başlanmış ve 7 gün süreile devam edilmiştir. Enginar uygulamasına CP uygulamasından 7 gün önce başlanmış ve 12 günsüre ile devam edilmiştir. Mesane dokusunda malondialdehid (MDA), redükte glutatyon (GSH)düzeyleri, katalaz (KAT), glutatyon-S-transferaz (GST) aktivite tayini yapılmıştır. Kontrol grubunagöre CP uygulanan grupta MDA (P= 0.013) ve GSH (P

Protective Effects of Propolis and Artichoke in Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats

In the study, the effects of propolis and artichoke on bladder toxicity induced by cyclophosphamide (CP) were investigated. The rats were divided into 6 groups. The groups were generated as control group, propolis-treated group (200 mg/kg/day gavage, 7 days), artichoke-treated group (1 g/kg/day gavage, 12 days), CP-treated group (150 mg/kg i.p. single dose), CP+propolis treated group and CP+artichoke-treated group. Propolis treatment was started for 2 days before the CP treatment and continued for 7 days. Artichoke treatment was started for 7 days before CP treatment and continued for 12 days. Malondialdehyde (MDA), reduced glutathione (GSH) levels, catalase (CAT) and glutathione-S-transferase (GST) activities were determined in the bladder tissue. In the CP treated group, MDA (P= 0.013) and GSH (P

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