Taner KASAR, Saadet AKARSU, Erdal YILMAZ

B-Talasemi Taşıyıcılarında Ventriküler Depolarizasyon ve Repolarizasyon Farklı mıdır?

Amaç: Ülkemizde -talasemi taşıyıcılığı (TM) görülme sıklığı %2.1’dir. Demir eksikliği anemisi (DEA) ve -talasemi majörde ventriküler depolarizasyon ve repolarizasyon değişimleri ile kardiyak otonomik disfonksiyon belirtilerine ait elektrokardiyografi (EKG)’de farklı değişiklikler saptanmıştır. Literatürde TM olan olgularda EKG değişiklikleri ile ilgili bir çalışmaya rastlamadık. Bizde, DEA ve -talasemi majör arasında bir tablo gösteren TM olgularındaki düzeltilmiş QT (QTc) ve QTc dispersiyonu (QTcd)’nu araştırmak istedik. Gereç ve Yöntem: Çalışma grubu Grup 1. (TM; n: 15), Grup 2. (DEA; n: 17), Grup 3. (Sağlıklı kontrol; n: 13)’den oluşturuldu. Ortalama yaş Grup 1’de 10.2±17.4 ay, Grup 2’de 13.2±14.5 ay ve Grup 3’de 13.5±2.5 ay olarak saptandı. Tüm olgulardan kan sayımı, serum demiri, demir bağlama kapasitesi, ferritin düzeyi, hemoglobin elektroforezi alındı ve 12 yüzeyli EKG ile kalp tepe atımı, RR, PR, QRS, QT, QTc ve QTcd hesaplandı. Üç gruptaki olgular tüm EKG değişkenleri yönüyle karşılaştırıldı. Bulgular: QTc TM 400 (200-450), DEA 410 (360-420) ve sağlam grupta 400 (380-440) msn saptandı. QTc, TM tanılı olgularda; sağlam gruba göre daha az saptandı. TM ve sağlam grup arasında istatistiksel anlamlı fark saptandı (p

Is Ventricular Depolarization and Repolarization Different in -Talasemi Carriers?

Objective: In our country the incidence of β-thalassemia minor (TM) is 2.1 percent. In cases with IDA, and β-thalassemia major, electrocardiographic (ECG) signs reflecting cardiac autonomic dysfunction, and changes in depolarization, and repolarization differ widely. We haven’t encountered any study related to changes in ECG signs in the literature. So we wanted to investigate corrected QT (QTc), and QTc dispersion (QTcd) in cases with TM which demonstrate clinical manifestations in between IDA, and β-thalassemia major. Material and Method: Study population consisted of Group 1 (TM; n: 15), Group 2 (IDA; n: 17), and Group 3 (healthy control; n:13). Mean ages of Groups 1, 2 and 3 were 10.2±17.4, 13.2±14.5, and 13.5±2.5 months, respectively. In all cases whole blood cell counts, levels of serum iron, iron binding capacity, and ferritin were evaluated, and hemoglobin electrophoresis was performed. Peak heart rate, RR, PR, QRS, QT, QTc and QTcd were calculated using 12-lead ECG. Groups in all 3 groups were compared as for all ECG variables. Results: QTc intervals were estimated for TM 400 (200-450), IDA 410 (360-420), and healthy control groups 400 (380-440) msn as indicated. QTc intervals in cases diagnosed as TM were shorter relative to IDA, and healthy control groups. A statistically significant difference was detected between TM, and healthy control groups (p

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