Reza KHEİRANDİSH, Javad TAJIK, Hamineh ROHANI, Shima ABBASI

Protective effects of vitamin E in experimentally induced rhabdomyolysis

Amaç: Ratlarda deneysel olarak oluşturulan rabdomiyoliz olgularında vitamin E uygulamasının koruyucu etkilerini değerlendirmektir.Gereç ve Yöntem: Yirmi bir adet rat üç eşit gruba ayrıldı: kontrol (Grup 1), gliserol (%50 gliserol, 7 mL/kg, IM) ve gliserol (%50 gliserol, 7 mL/kg, IM) + vitamin E grup (100 mg/ kg, IP, SID). Gliserol uygulamasından doksan altı saat sonra kan örnekleri alındı. Serumdan kreatinin, kan üre nitrojen, kreatin kinaz, aspartat aminotransferaz, alanin aminotransferaz ve laktat dehidrogenaz düzeyleri ölçüldü. Karaciğer ve böbrek dokusunun histopatalojik incelemesi yapıldıBulgular: Gliserol + vitamin E grubu kreatinin, laktat dehidrogenaz ve kreatin kinaz düzeyleri gliserol grubundan düşük (p

Deneysel rabdomiyolizde vitamin E'nin koruyucu etkileri

Aim: Evaluation of the protective effects of vitamin E administration in a rat model of rhabdomyolysis.Material and Method: Twenty one rats were divided to three equal groups; control (Group 1), glycerol (50% glycerol, 7 mL/kg, IM) and glycerol (50% glycerol, 7 mL/kg, IM) + Vitamin E (100 mg/kg, IP, SID). Ninety-six hours after glycerol injection, blood samples were collected. Serum creatinine, blood urea nitrogen, creatine kinase, aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase levels were measured. Histopathologic pattern of hepatic and renal tissue damages was also evaluated.Results: Glycerol + vitamin E groups had lower (P

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