Hüseyin Serkan EROL, Tuba AYDIN, Mesut Bünyami HALICI, İsmail CAN, Serkan YILDIRIM

Oleuropeinin çekal ligasyon ve punktur ile indüklenen sepsiste akciğer ve kalp hasarı üzerine etkileri

The effects of oleuropein on lung and heart injury in cecal ligation and puncture - induced sepsis

Aim: Sepsis is a fatal serious clinical disorder. The oxidative stressin sepsis plays an important role in the inflammation. Therefore, theeffects of oleuropein (OLE) and ceftriaxone (CEFT) on sepsis wereinvestigated in this study.Materials and Methods: Thirty male rats were divided into fiveequal groups: Sham, Sepsis, CEFT, OLE-150 and OLE-300, The150 mg/kg of ceftriaxone (i.p.), and 150 and 300 mg/kg OLE (p.o.)were administered to the treatment groups fifteen minutes beforethe experiment. After 24 hours, blood samples, lungs and hearts tissues were taken. The creatine kinase (CK) and lactate dehydrogenase (LDH) activities in serum, lipid peroxidation (LPO), glutathione(GSH), superoxide dismutase (SOD) and catalase (CAT) levels wereall determined. In addition, the expressions of the interleukin (IL)-8in lung and tumor necrosis factor (TNF)-α in heart were pathologically and immunohistochemically were determined.Results: Sepsis caused significant increases in CK, LDH, LPO, GSHand heart CAT activity and caused inhibition of SOD and lung CATactivity (p

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Aebi H, 1984. Catalase in vitro. Methods Enzymol, 105, 121- 126.
Alirezaei M, Dezfoulian O, Kheradmand A, 2015. Novel Antioxidant properties of ghrelin and oleuropein versus lipopolysaccharide-mediated renal failure in rats. Int J Pept Res Ther, 21(4), 411-421.
Allen TC, Kurdowska A, 2013. Interleukin 8 and acute lung injury. Arch Pathol Lab Med, 138(2), 266-269.
Andrades M, Ritter C, Moreira JCF, Dal-Pizzol F, 2005. Oxidative Parameters Differences during Non-Lethal and Lethal Sepsis Development1. J Surg Res, 125(1), 68-72.
Bar-Or D, Carrick MM, Mains CW, Rael LT et al., 2015. Sepsis, oxidative stress, and hypoxia: are there clues to better treatment? Redox Rep, 20(5), 193-197.
Biolo G, Antonione R, De Cicco M, 2007. Glutathione metabolism in sepsis. Crit Care Med, 35(9 Suppl), S591-595. Blaser H, Dostert C, Mak TW, Brenner D, 2016. TNF and ROS crosstalk in inflammation. Trends Cell Biol, 26(4), 249- 261.
Cadirci E, Altunkaynak BZ, Halici Z, Odabasoglu F et al., 2010. α-lipoic acid as a potential target for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats. Shock, 33(5), 479-484.
Cicerale S, Lucas L, Keast R, 2012. Antimicrobial, antioxidant and anti-inflammatory phenolic activities in extra virgin olive oil. Curr Opin Biotechnol, 23(2), 129-135.
Constantino L, Gonçalves RC, Giombelli VR, Tomasi CD et al., 2014. Regulation of lung oxidative damage by endogenous superoxide dismutase in sepsis. Intensive Care Med Exp, 2(1), 17.
Crimi E, Ignarro L, Napoli C, 2007. Microcirculation and oxidative stress. Free Radic Res, 41(12), 1364-1375. Erol N, Saglam L, Saglam YS, Erol HS et al., 2019. The Protection Potential of Antioxidant Vitamins Against Acute Respiratory Distress Syndrome: a Rat Trial. Inflammation, 42(5), 1585-1594.
Feng Z, Li X, Lin J, Zheng W et al., 2017. Oleuropein inhibits the IL-1β-induced expression of inflammatory mediators by suppressing the activation of NF-κB and MAPKs in human osteoarthritis chondrocytes. Food Funct, 8(10), 3737- 3744.
Geyikoglu F, Isikgoz H, Onalan H, Colak S et al., 2017. Impact of high-dose oleuropein on cisplatin-induced oxidative stress, genotoxicity and pathological changes in rat stomach and lung. J Asian Nat Prod Res, 19(12), 1214-1231. Giamarellos-Bourboulis EJ, Geladopoulos T, Chrisofos M, Koutoukas P et al., 2006. Oleuropein: a novel immunomodulator conferring prolonged survival in experimental sepsis by Pseudomonas aeruginosa. Shock, 26(4), 410-416.
Gray K, 2017. Introduction of a sepsis bundle in the ICU and ER: a case-based discussion. Vet Nurs J, 32(12), 365-368. Halliwell B, 2005. Free radicals and other reactive species in disease. eLS, 1-9.
Hassen I, Casabianca H, Hosni K, 2015. Biological activities of the natural antioxidant oleuropein: Exceeding the expectation–A mini-review. J Funct Foods, 18, 926-940. Keir I, Dickinson AE, 2015. The role of antimicrobials in the treatment of sepsis and critical illness‐related bacterial infections: Examination of the evidence. J Vet Emerg Crit Care, 25(1), 55-62.
Khalili HR, Adeli Behrooz HR, Rashidi Nooshabadi MR, Geravandi S et al., 2018. Evaluation of potential anti-fibrotic effect of oleuropein on bleomycin-induced pulmonary fibrosis in rat. Toxin Rev, 1-9. Kısa A, Akyüz M, Çoğun HY, Kordali Ş et al., 2018. Effects of Olea europaea L. leaf metabolites on the tilapia (Oreochromis niloticus) and three stored pests, Sitophilus granarius, Tribolium confusum and Acanthoscelides obtectus. Rec Nat Prod, 12(3), 201.
Koc K, Cerig S, Ucar S, Colak S et al., 2018. Gastroprotective effects of oleuropein and thymol on indomethacin-induced gastric ulcer in Sprague-Dawley rats. Drug Chem Toxicol, 1-13.
Kruk I, Aboul‐Enein HY, Michalska T, Lichszteld K et al., 2005. Scavenging of reactive oxygen species by the plant phenols genistein and oleuropein. Luminescence, 20(2), 81-89.
Lee O-H, Lee B-Y, 2010. Antioxidant and antimicrobial activities of individual and combined phenolics in Olea europaea leaf extract. Bioresour Technol, 101(10), 3751-3754.
Marikovsky M, Ziv V, Nevo N, Harris-Cerruti C et al., 2003. Cu/ Zn superoxide dismutase plays important role in immune response. J Immunol, 170(6), 2993-3001.
Ohkawa H, Ohishi N, Yagi K, 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem, 95(2), 351-358.
Ozogul B, Halici Z, Cadirci E, Karagoz E et al., 2015. Comparative Study on Effects of Nebulized and Oral Salbutamol on a Cecal Ligation and Puncture-Induced Sepsis Model in Rats. Drug Res (Stuttg), 65(04), 192-198.
Pandır D, Per S, Doğanyiğit Z, Bekdemir FO et al., 2019. All aspects of the toxic effects of lipopolysaccharide on rat liver and the protective effect of vitamin E and sodium selenite. Turk J Zool, 43(6), 566-579.
Park J, Min J-S, Chae U, Lee JY et al., 2017. Anti-inflammatory effect of oleuropein on microglia through regulation of Drp1-dependent mitochondrial fission. J Neuroimmunol, 306, 46-52.
Pourkhodadad S, Alirezaei M, Moghaddasi M, Ahmadvand H et al., 2016. Neuroprotective effects of oleuropein against cognitive dysfunction induced by colchicine in hippocampal CA1 area in rats. J Physiol Sci, 66(5), 397-405.
Qabaha K, AL-Rimawi F, Qasem A, Naser SA, 2018. Oleuropein is responsible for the major anti-inflammatory effects of olive leaf extract. J Med Food, 21(3), 302-305.
Rocha M, Herance R, Rovira S, Hernández-Mijares A et al., 2012. Mitochondrial dysfunction and antioxidant therapy in sepsis. Infect Disord Drug Targets, 12(2), 161-178.
Ryu S-J, Choi H-S, Yoon K-Y, Lee O-H et al., 2015. Oleuropein suppresses LPS-induced inflammatory responses in RAW 264.7 cell and zebrafish. J Agric Food Chem, 63(7), 2098- 2105.
Sedlak J, Lindsay RH, 1968. Estimation of total, proteinbound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem, 25, 192-205.
Spanos A, Jhanji S, Vivian-Smith A, Harris T et al., 2010. Early microvascular changes in sepsis and severe sepsis. Shock, 33(4), 387-391.
Sun Y, Oberley LW, Li Y, 1988. A simple method for clinical assay of superoxide dismutase. Clin Chem, 34(3), 497-500.
Şahin S, Samli R, Tan ASB, Barba FJ et al., 2017. Solvent-free microwave-assisted extraction of polyphenols from olive tree leaves: Antioxidant and antimicrobial properties. Molecules, 22(7), 1056.
Wang F, Jin Z, Shen K, Weng T et al., 2017. Butyrate pretreatment attenuates heart depression in a mice model of endotoxin-induced sepsis via anti-inflammation and antioxidation. Am J Emerg Med, 35(3), 402-409.