Koyunlarda karprofenin çoklu doz uygulamalarının hematolojik ve biyokimyasal parametreler üzerine etkisi

Amaç: Bu araştırmanın amacı koyunlarda karprofenin farklı dozlarda tekrarlayan damar içi uygulamasını takiben hematolojik ve biyokimyasal parametrelere etkisini belirlemektir.Gereç ve Yöntem: Araştırmada, Akkaraman ırkı, 20 adet sağlıklıkoyun kullanıldı. Çalışmada hayvanlar rastgele iki eşit gruba ayrıldı.Karprofen birinci grupta bulunan koyunlara 4 mg/kg dozda, ikincigrupta bulunan koyunlara ise 16 mg/kg dozda damar içi yolla gündebir defa 5 gün boyunca uygulandı. Kan örnekleri 0., 12., 24., 48., ve120. saatlerde alınarak hemogram ve biyokimyasal panel değerlendirildi.Bulgular: Karprofenin doz grupları arasında hematolojik ve biyokimyasal parametrelerde herhangi farklılık belirlenmedi. 4 mg/kggrubunda en yüksek potasyum, kan üre nitrojen, aspartat aminotransferaz ve total protein seviyesi 12. saatte tespit edildi. 16 mg/kggrubunun en yüksek troponin-I seviyesi 12. saatte görüldü. Ayrıca16 mg/kg dozda alyuvar, hemoglobin ve eritrosit düzeylerindeki düşüşün daha belirgin olduğu ve bu değişimin normal referans değerler içinde olduğu görüldü.Öneri: Sonuç olarak koyunlarda karprofenin 4 mg/kg ve 16 mg/kgdozlarda beş gün süre ile güvenle kullanılabileceği görüldü. Ancakgüvenilirliğin histopatolojik ve moleküler düzeyde ortaya konulmasına ihtiyaç vardır

Effect of multiple-dose administration of carprofen on hematological and biochemical parameters in sheep

Aim: The aim of this study was to determine the effects of carprofen on hematological and biochemical parameters following repeated intravenous administration of different doses. Materials and Methods: Twenty healthy Akkaraman sheep were enrolled. The animals were randomly divided into two equal groups. Carprofen was administered intravenously to the sheep in the first group at a dose of 4 mg/kg, and to the sheep in the second group at a dose of 16 mg/kg once a day for 5 days. To evaluation of hemogram and biochemical panel blood samples were taken before carprofen administration (0 hours) and 12, 24, 48, and 120 hours after admi nistration. Results: There was no difference between hematological and bioc hemical parameters of different dose administration groups. The highest potassium, blood urea nitrogen, aspartate amino transferase and total protein levels were determined at the 12th hour after ad ministration of 4 mg/kg carprofen. The highest troponin-I level was seen at the 12th hour after administration of 16 mg/kg carprofen. However, the decrease in the levels of red blood cells, hemoglobin and hematocrit at a dose of 16 mg/kg was more marked, this change was within the normal reference values. Conclusion: It has been observed that carprofen can be used safely at 4 mg/kg and 16 mg/kg doses for 5 days in the sheep. However, safety needs to confirm by histopathological and molecular studies.

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