Mısır şurubu ve trans yağ ilave edilen yemle beslenen ratlarda lipit profilleri ile hemoglobin A1c (HbA1c), alkalen fosfataz (ALP), aspartat aminotransferaz (AST), süperoksit dismutaz (SOD) değerlerinin belirlenmesi

Amaç: Son yıllarda mısır şurubu ve trans yağlar gıda üretimi ve tüketiminde önemli bir yere sahiptir. Trans yağlar (TF) ve yüksek fruktozlu mısır şurubunun (HFCS) sağlık üzerinde benzer olumsuz etkilere neden olabileceğinden yola çıkılarak, diyette HFCS ve TF alımını sonucunda organizmada meydana gelen bazı biyokimyasal parametrelerindeki değişiklikleri belirlemek çalışmanın amacını oluşturmaktadır. Gereç ve Yöntem: Wistar Albino erkek sıçanlar (n = 24) 4 eşit gruba ayrıldı. Kontrol grubu (C) 8 hafta boyunca standart fare yemi, 2. grup pamuk yağı, 3. grup trans yağ ve 4. grup trans yağ ve mısır şurubu ile beslendi. Çalışma gruplarından anestezi altında 0. günde supraorbital yöntemle ve 60. günde intrakardiyak yöntemle kan alımı gerçekleştirildi. Glukoz, HbA1c, trigliserit, kolesterol, HDL, LDL, AST, ALT, ALP, SOD ve GGT analizleri yapıldı. Bulgular: Sunulan çalışmada trans yağların, trigliserit konsantrasyonunu arttırdığı, HDL konsantrasyonunu azalttığı, bazı karaciğer enzim değerlerinde değişmelere neden olduğu görülmüştür. Glukoz ve trigliserit konsantrasyonunda artış, HDL ve GGT analizlerinde azalma istatistiksel olarak anlamlıydı (p ˂ 0.05). LDL, AST ve HbA1c analizlerindeki artış ve azalma istatistiksel olarak anlamlı değildi (p ˃ 0.05). Öneri: Gıdalarda bulunan yüksek fruktozlu mısır şurubu ve trans yağ asidi miktarının mümkün olduğunca sınırlandırılması gerektiği ve bu sınırlamaların insan sağlığını olumlu etkileyeceği sonucuna varıldı.

Determination of hemoglobin A1c (HbA1c), alkaline phosphatase (ALP), aspartate aminotransferase (AST), superoxide dismutase (SOD) values and lipid profiles in rats fed with corn syrup and trans oil added diets

Aim: In recent years, corn syrup and trans fats have an important place in food production and consumption. Since trans fats (TF) and high fructose corn syrup (HFCS) can cause similar negative effects on health, the aim of this study was to determine the changes in some biochemical parameters of an organism following the intake of HFCS and TF in the diet. Materials and Methods: Wistar Albino male rats (n = 24) were divided 4 equal groups. Control group (C) was fed with a standard rat feed, 2nd group with cotton fat, 3rd group with trans fat, and 4th group with trans fat and corn syrup for 8 weeks. Blood samples were collected on day 0 by the supraorbital method and on day 60 by the intracardiac method under anesthesia. Glucose, HbA1c, triglyceride, cholesterol, HDL, LDL, AST, ALT, ALP, SOD, and GGT analyzes were performed. Results: In the present study, trans fats increased triglyceride concentration, decreased HDL concentration and caused changes in some liver enzyme values. Increase in glucose and triglyceride concentration and decrease in HDL and GGT analyzes were statistically significant (p ˂ 0.05). The increase and decrease in LDL, AST and HbA1c analyzes were not statistically significant (p ˃ 0.05). Conclusion: High fructose corn syrup and trans fatty acid found in foods ıt was concluded that the amount should be limited as much as possible, and these limitations will positively affect human health.

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