Kalori kısıtlaması uygulanan farelerde biyokimyasal değerler

.Amaç: Erkek farelerde (Swiss Albino) gerçekleştirilen bu çalışmada yem (kalori) kısıtlamasının kan lipit peroksidasyonu (LPO), protein karbonil (PC), HDL ve LDL kolesterol, trigliserit (TG), aspartat amino transferaz (AST) ve glikoz gibi temel biyokimyasal parametreler ile canlı ağırlık değerlerine olası etkileri araştırılmıştır.Gereç ve Yöntem: Araştırmada hayvan materyali olarak 96 adet 6-8 aylık yaşta Swiss Albino erkek fare kullanılmış; deneme başlangıcında hayvanlar tartılarak canlı ağırlıkları homojen ve her kafeste 8 adet fare olacak şekilde 1.Kontrol, 2.Kalori kısıtlanmış (% 40) grup, 3.Kalori kısıtlanmış (% 60) grup olmak üzere 3 ayrı grup halinde barındırılmışlardır. Araştırma Selçuk Üniversitesi Veteriner Fakültesi Deneysel Araştırma Ünitesinde 60 gün süreli yürütülmüştür. Denemede 10 günlük adaptasyon döneminden sonra deneme başında (1.gün) kalp içinden kan alınmış, aynı uygulamalar 30 ve 60. günlerde tekrarlanmıştır. Bulgular: LPO ve PC değerleri 2. ve 3. gruplarda 30 ve 60. gün incelemelerinde devamlılık ifade eden düşüş göstermiş (P

Cakici O, Kurtoglu F. Biochemical values of male mice fed with restricted calorie diet

Cakici O, Kurtoglu F. Biochemical values of male mice fed with restricted calorie diet.Aim: In this study, the effects of calorie restriction on basic biochemical parameters such as blood lipid peroxidation (LPO), protein carbonyl (PC), HDL and LDL cholesterol, triglycerides (TG), aspartate amino transferase (AST), glucose and body weight of male mice (Swiss Albino) were investigatedMaterials and Methods: Ninety six Swiss Albino male mice that have 6-8 months of age and body weight close to by each other were used in the study. Before starting the experiment, all animals were weighed and distributed in groups according to homogenity for theirs body weight. The research lasted for 60 days and conducted at Selcuk University, Faculty of Veterinary Medicine Experimental Animal Research Unit. Mice were divided into 3 groups in each subgroups be of 8 mice and were fed in standard mice cages These groups organized as follows; 1-Control; 2- Calorie restricted (40%); 3- Calorie restricted (60%). After the adaptation period of 10 days, at the beginning; 30; and 60 days blood samples were taken by cardiac puncture.Results: LPO and PC values of 2nd and 3rd showed continuity declines (P

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Agarwal S, Sharma S, Agarwal V, Roy N, 2005.Caloric restriction augments ROS defence in S. Cerevisiae, by a Sir2- independent mechanism. Free.Radic.Res, 39, 55-62.
Akman C, Zhao Q, Liu X, Holmes GL, 2004. Effect of food deprivation during early development on cognition and neurogenesis in therat. Epilepsy and Behavior, 5, 446–454.
Alvers AL, Fishwick LK, Wood MS, Hu D, Chung HS, Dunn Jr WA, Aris JP, 2009. Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae. Aging Cell, 8, 353–369.
Aruoma OI, 1994. Nutrition and health aspects of free radicals and antioxidant. Food Chem Toxic, 32, 671-683.
Başpınar N, Kurtoğlu F. Vitaminler. Birinci Baskı, S.Ü. Veteriner Fakültesi Yayın Ünitesi. Konya. 2003.
Brookes PS, Land JM, Clark JB, Heales SJR, 1998. Peroxynitrite and brain mitochondria: evidence for increased proton leak. J Neurochem, 70, 2195–2202.
Brownlee M, 1992. Glycation products and the pathogenesis of diabetic complications. Diabetes Care, 15, 1835.
Cao SX, Dhahbi JM, Mote PL, Spindler SR, 2001. Genimic profiling of short and long term calorie restriction effects in the liver of aging mice. Proc Natl Acad Sci, 98, 10630-10635.
Cartee GD, Dean DJ, 1994. Glucose transport with brief dietary restriction. Heterogenous responses in muscles, Am J Physiol, 266, E946–E952.
Chacon F, Cano P, Jimenez V, Cardinali DP, Marcos A, Esquifino AI, 2004. 24-hour changes in circulating prolactin, follicle-stimulating hormone, luteinizing hormone, and testosterone in young male rat ssubjected to calorie restriction. Chronobiol Int, 21, 393–404.
Chaney SG, Principles of Nutrition I-II. In: Devlin Thomas M, Editor. Textbook of Biochemistry with Clinical Correlations 4th ed. New York: Von Hoffmann Press; 997; pp. 1087-1137
Choi JH, Yu BP, 1995. Brain synaptosomal ageing: free radicals and membrane fluidity. Free Radic Biol.Med, 18, 133- 139.
Coomes MW, 1997. In: Devlin Thomas M, Editor. Textbook of Biochemistry with Clinical Correlations 4th ed. New York: Von Hoffmann Press;. pp. 445-456.
Cunha FM, Demasi M, Kowaltowski AJ, 2011. Aging and calorie restriction modulate yeast redoxstate, oxidized protein removal, and the ubiquitin-proteasome system, Free Radi cal Biology and Medicine, 51, 664-670.
Cutler RG, Davis BJ, Ingram DK, Roth GS, 1992. Plasma concentrations of glucose, insulin and percent glycosylated hemoglobin are unaltered by food restriction in rhesus and squirrel monkeys. J Gerontol Biol Sci, 47, B9–B12.
Dixit R, Coleman JB, Mattson B, Balam GC, Kenan KP, Louis MO, 2006. The effects of uncontrolled excess caloric intake and moderate to marked caloric restriction (CR) on obesity, spontaneous disease and cancers in Sprague Dowley rats. Neurology, 67, 1208-1214.
Drew B, Phaneuf S, Dirks A, Selman C, Gredilla R, Lezza A, Barja G, Leeuwenburgh C, 2003. Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart. Am J Physiol, 284, R474-R480.
Fabrizio P, Gattazzo C, Battistella L, Wei C, Cheng M, Mc Grew K, Longo VD, 2005. Sir2 blocks extreme life span extension. Cell, 23,655–667.
Fernandes G, 1994. Dietary lipids and risk of autoimmune disease. Clin Immunol Immunopathol, 2, 193–197.
Fontana L, Meyer TE, Klein S, Holloszy JO, 2004. Long-term calori restriction is highly effective in reducing the risk for in atherosclerosis humans. Proc Natl Acad Sci, 101, 659– 666.
Forster MJ, Lal H, 1999. Estimating age-related changes in psychomotor function: influence of practice and of level of caloric intake in different genotypes. Neurobiol Aging, 20, 167-76.
Goldberg AA, Bourque SD, Kyryakov P, Gregg C, Boukh-Viner T, Beach A, Burstein MT, Machkalyan G, Richard V, Rampersad S, Cyr D, Milijevic S, Titorenko V, 2009. Effect of calorie restriction on the metabolic history of chronologically aging yeast. Exp Gerontol, 44, 555–571.
Guo Z, Raymundo FM, Yang H, Ikeno Y, Nelson J, Diaz V, Richardson A, Reddick R, 2002. Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice. Mechanisms of Ageing and Development, 123, 1121-1131.
Guthrow CE, Morris MA, Day JF, Thorpe SR, Baynes JW, 1979. Enhanced nonenzymatic glucosylation of human serum albumin in diabetes mellitus. Proc Natl Acad Sci, 76, 4258– 4261.
Gutteridge JMC, Halliwell B, 1993. Transition metal ions and antioxidant proteins in extracellular fluids In: Atmospheric Oxidation and Antioxidant Ed. Schott G. Amsterdam, pp. 71-95.
Hagen TM, Yowe DL, Bartholomew JC, 1997. Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase. Proc Natl Acad Sci 94, 3064-3069.
Hagopian K, Ramsey JJ, Weindruch R, 2003. Caloric restriction increases gluconeogenic and transaminase enzyme activities in Mouse liver. Exp Gerontol, 38, 267-278.
Hagopian K, Ramsey JJ, Weindruch R, 2005. Fructose metabolizing enzymes from Mouse liver: influence of age and caloric restriction. Biochimica et Biophysica Acta, 1721, 37- 43. Hagopian K, 2005. Krebs cycle enzymes from livers of old mice are differantially regulated by caloric restriction. Phsiol and Behavior, 85, 581-592.
Harris RA, Crabb DW, 1997. Metabolic Interrelationsships In: Textbook of Biochemistry with Clinical Correlations, Ed. . Devlin Thomas M, 4th ed. New York: Von Hoffmann Press; p.525-547.
Heilbonn LK, Ravussion E, 2003. Calorie restriction and aging: review of the literature and implications for studies in humans. Ann J Clin Nutr,78, 361-369.
Hopfer U. Digestion and Absorbtion of Basic Nutritional Constituents, 1997. In: Textbook of Biochemistry with Clinical Correlations, Ed. Devlin Thomas M, 4th ed. New York: Von Hoffmann Press;. pp. 1056-1083
Ingram DK, Weindruch R, Spangler EL, Freeman JR, Walford RL, 1987. Dietary restriction benefits learning and motor performance of aged mice. J Gerontol, 42, 78-81.
Kargın F, Fidancı UR, 2000. Serbest oksijen radikaller ve oksidatif hasar. Türk Veteriner Hekimliği Dergisi, 3, 26-28.
Kim JD, McCarter RJM, Yu BP, 1996. Influence of age, exercise and dietary restriction on oxidative stres in rats. Ageing Clin Exp Res, 8, 123-129.
Lane MA, Ball SS, Ingram DK, Tilmont EM, Cutler RG, Roth GS, 1995. Diet restriction in rhesus monkeys lowers fasting and glucose-stimulated glucoregulatory end points. Am J Physiol, 268, E941–E948.
Lane MA, Black A, Hand YA, Tilmont EM, Ingram DK, Roth GS, 2001. Caloric restriction in primates, Ann N Y Acad Sci, 928, 287–295.
Lee AT, Cerami A, 1992. Role of glycation in aging. Ann NY Acad Sci, 663, 63-70.
Lee J, Yu BP, Herlihy JT, 1999. Modulation of cardiac mitochondrial membrane fluidity by age and calorie intake. Free Radic Biol Med, 26, 260–265.
Lee CK, Allison, DB, Brand J, Weindruch R, Prolla TA, 2002. Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts. Proc Natl Acad Sci, 99, 14988–14993.
Lewis SEM, Goldspink DF, Phillips JG, Merry BJ, Holehan AM, 1985. The effects of aging and chronic dietary restriction on whole body growth and protein turnover in the rat. Exp Gerontol, 20, 253-263.
Longo VD, Fontana L, 2009. Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends in Pharmacol Sci, 2, 31-37.
Luvizotto AM, Sandro JC, Sibio MT, Nascimento AF, Lima-Leopoldo AS, Padovani CR, Cicogna AC, Nogueira CR, 2010. Administration of physiologic levels of triiodothronine increases leptin expression in calorie-restricted obese rats, but does not influence weight loss. Met.Clin.and Exp, 59,1-6.
Lysons TJ, 1993. Glycation and oxidation; a role in the pathogenesis of atherosclerosis. Am J Cardiol, 71, 26B.
Maalouf M, Rho JM, Mattson MP, 2009. The neuroprotective properties of calorie restriction, the ketogenic diet and ketone bodies. Brain Res Rew, 59, 293-315.
Markovic TP, Jenkins AB, Campbell LV, Furler SM, Kraegen EW, Chisholm DJ, 1998.The determinants of glycemic res ponses to diet restriction and weight loss in obesity and NIDDM. Diabetes Care, 21, 687-694.
Masoro EJ, Katz MS, McMahan CA, 1989. Evidence for the glycation theory of aging from the food-restricted rodent model. J Gerontol Biol Sci, 44, B20–B22.
McVerry BA, Fisher C, Hopp A, Huehns ER, 1980. Production of pseudodiabetic renal glomerular changes in mice after repeated injections of glucosylated proteins. Lancet,, 738–740.
Merry BJ, 2002. Molecular mechanism slinking calorie restriction and longevity. The Int J of Biochem and Cell Biol, 34, 1340–1354.
Merry BJ, 2005. Dietary restriction in rodents- delayed or retarded ageing? Mech Aging Dev, 126, 951-959.
Niki E, 1993. Lipid peroxidation and its inhibition In: Atmospheric Oxidation and Antioxidants, Ed. Scott G, Amsterdam. pp. 1-26.
Oliveira GA, Tahara EB, Gombert AK, Barros MH, Kowaltowski AJ, 2008. Increased aerobic metabolism is essential for the beneficial effects of caloric restriction on yeast life span. J Bioenerg Biomembr, 40, 381-388.
Öz N, Kurtoğlu F, 2002. Serbest radikaller ile antioksidan sistemler ve hastalıklarla ilişkileri. J of Konya Vet Cont and Res Inst, 13, 21-31.
Pitsikas N, Carli M, Fidecka S, Algeri S, 1990. Effect of lifelong hypocaloric diet on age-related changes in motor and cognitive behavior in a rat population. Neurobiol Aging, 11, 417-423.
Pryor WA, Porter NA, 1990. Suggested mechanism for the production of 4-hydroxy-2- nonenal, from the autoxidation of polyunsaturated fatty acids. Free Rad Biol Med, 8, 541-543.
Rebrın I, Kamzalov S, Sohal RS, 2003. Effects of age and caloric restriction on glutathione redoxstate in mice. Free Rad Biol.Med, 6, 626–635.
Reiser K, Mcgee C, Rucker R, Mcdonald R, 1995. Effect of aging and caloric restriction on extracellular-matrix biosynthesis in a model of injury repair in rats. J of Geront Series A- Biol Sci.and Med Sci, 50, B40-B47.
Redman LM, Ravussin E, 2009. Endocrine alterations in response to calorie restriction in humans. Molecular and Cell Endocrinol, 299, 129-136.
Rolfe DFS, Brown GC, 1997. Cellular energy utilization and moleculer origin of standard metabolic rate in mammals. Physiol Rev, 77, 731-758.
Schwartz NB, 1997. In: Textbook of Biochemistry with Clinical Correlations. Ed. Devlin Thomas M, 4th ed. New York: Von Hoffmann Press;. pp. 335-352
Scrofano MM, Hodge JJ, Nowell TR, Gong X, Smith DE, Perrone G, Asmundsson G, Dallal G, Gindlesky B, Mura CV, Taylor A, 1998. The effects of aging and calorie restriction on plasma nutrient levels in male and female Emory mice. Mech Aging Dev, 105, 31–44.
Selman C, Phillips T, Staib JL, Duncan JS, Leeuwenburgh JR, 2005. Energy expenditure of calorically restricted rats is higher than predicted from their altered body composition. Mech Ageing Dev, 126, 783-793.
Sharma PK, Agrawal V, Roy N, 2011. Mitochondria-mediated hormetic response in life span extension of calorie-restricted Saccharomyces cerevisiae. Age, 33, 143–154.
Smith MA, Taneda S, Richey PL, 1994. Advanced Maillard reaction end products are associated with Alzheimer disease pathology. Proc Natl Acad Sci, 91, 5710-5714.
Sohal RS, Weindruch R. 1996. Oxidative stress, caloric restriction and aging. Science, 273, 59-63.
Speakman JR, Mitchell SE, 2011. Caloric restriction. Molec Aspects of Med, 32, 159-221.
Spindler SR, 2001. Caloric restriction enhances the expression of key metabolic enzymes associated with protein renewal during aging. Acad Sci, 928, 296-304.
Sprott RL, 1997. Diet and calorie restriction. Exp Gerontology, 32, 205-214.
SPSS for Windows version 21 SPSS Inc. (Statistical Package for the Social Sciences. Chicago, IL, United States). 2012.
Stein O, Dabach Y, Halperin G, Naim MB, Stein Y, 2003. Calorie restriction in mice does not affect LDL reverse cholesterol transport in vivo. Biochem and Biophysic Res Com, 308, 29-34.
Stewart J, Mitchell J, Kalant N, 1989. The effects of life-long food restriction on spatial memory in young and aged Fischer 344 rats measured in the eight-arm radial and the Morris water mazes. Neurobiol Aging, 10, 669-675.
Troyer DA, Venkatraman JT, Fernandes G, 1998. Effects of calorie restriction and ω-3 dietary fat on aging in short- and long-lived rodents. Age, 21, 175-182.
Van Liew JB, Davis PJ, Davis FB, Bernardis LL, Deziel MR, Marinucci LN, Kumar D, 1993. Effects of aging, diet, and sex on plasma glucose, fructosamine, and lipid concentrations inbarrier-raised Fischer 344 rats. J Gerontol Biol Sci, 48, B184-B190.
Vlassara H, Striker LJ, Teichberg S, Fuh H, Li YM, Steffes M, 1994. Advanced glycation end products induce glomerular sclerosis and albuminuria in normal rats. Proc Natl Acad Sci, 91, 11704–11708.
Weindruch R, Keenan KP, Carney JM, Fernandes G, Feuers RJ, Halter JB, Ramsey JJ, Richardson A, Roth GS, Spindler SR, 2001. Caloric Restriction Mimetics: Metabolic Interventions. J of Gerontol, SERIES A, 56, 20-33.
Weindruch R, Sohal RS, 1997. Caloric intake and aging. The New England J of Med, 337, 986-994.
Wickens AP, 2001. Ageing and the free radical theory. Resp Physiol, 128, 379-391.
Xia E, Rao G, Van Remmen H, 1994. Activities of antioxidant enzymes in varios issues of male Fischer 344 rats are altered by food restriction. J Nutr, 125, 195-201.
Yang MH, Schaich KM, 1996. Factors affecting DNA damage caused by lipid hydroperoxides and aldehydes. Free Radic Biol Med, 20, 225-236.
Yılmaz N, 2007. Ratlarda Kalori kısıtlamasının NMDA reseptör subünit konsantrasyonları üzerine etkisi. Süleyman Demirel Üniversitesi Tıp Fakültesi Biyokimya ve Klinik Biyokimya Dergisi, 21-22.
Yu BP, Suescun EA, Yang SY, 1992. Effect of age related lipid peroxidation on membrane fluidity and phospholipase A2 modulation by dietary restriction. Mech Ageing Dev, 65, 17-33.
Yu BP, 2005. Membrane alteration as a basis of aging and the protective effects of calorie restriction. Mech of Aging Dev, 126, 1003-1010.
Ziyadeh FN, Cohen MP, 1993. Effects of glycated albumin on mesangial cells: evidence for a role in diabetic nephropathy. Mol Cell Biochem, 125, 19-25.