Keskin E, Uluışık D. Streptozotosin ile diyabet oluşturulan ratlarda Koenzim Q10 (CoQ10)’un hematolojik etkileri

.Amaç: Bu çalışmada streptozotosin ile diyabet oluşturulan ratlarda Koenzim Q10 (CoQ10)'un bazı hematolojik parametreler üzerine etkilerinin belirlenmesi amaçlandı.Gereç ve Yöntem: : Bu amaçla 38 adet sağlıklı, yetişkin erkek rat beş gruba ayrıldı. Dört hafta boyunca 1. gruptaki hayvanlar standart rat yemi ile beslenirken, 2. gruptaki hayvanlara dört hafta boyunca günlük 0,3 ml mısır yağı intraperitoneal (IP) olarak uygulandı. Aynı süre ile 3. gruptaki hayvanlara günlük 10 mg/kg CoQ10 IP olarak enjekte edildi. 4. gruptaki hayvanlarda 40 mg/kg streptozotosinin günde tek doz olmak üzere iki gün subkutan (SC) enjeksiyonu ile diyabet oluşturulurken, aynı yolla diyabet oluşturulan 5. gruptaki hayvanlara dört hafta boyunca günlük 10 mg/kg CoQ10 IP olarak enjekte edildi. Bütün hayvanlardan alınan kan örneklerinde alyuvar (RBC) ve akyuvar (WBC) sayıları, hemoglobin miktarı, hematokrit değer (PCV), lökosit yüzdeleri ile ortalama alyuvar hacmi (MCV), ortalama alyuvar hemoglobini (MCH) ve ortalama alyuvar hemoglobin konsantrasyonu (MCHC) belirlendi.Bulgular: Streptozotosin ile diyabet oluşturulan ratların RBC, hemoglobin miktarı ve hematokrit düzeylerinin kontrol grubuna göre anlamlı olarak düşük olduğu (p

Hematological effects of Coenzyme Q10 in streptozotocin-induced diabetic rats

Keskin E, Uluisik D. Hematological effects of Coenzyme Q10 in streptozotocin-induced diabetic rats.Aim: This study was conducted to evaluate the effects of Coenzyme Q10 on some hematological parameters in streptozotocin-induced diabetic rats.Materials and Methods: In the experiment, 38 healthy, adult male rats were divided into five groups. Group 1 was fed standard rat pellets for four weeks. Group 2 was administered with 0,3 ml corn oil IP daily for four weeks, group 3 was injected IP with 10 mg/kg CoQ10 daily for four weeks, group 4 was made diabetic by SC injections of 40 mg/kg streptozotocin as single daily dose for two days, group 5 was made diabetic by SC injections of streptozotocin in the same way and then was injected IP with 10 mg/kg CoQ10 daily for four weeks. In blood samples received from all animals, red blood cells (RBC) and white blood cells (WBC) counts, hemoglobin amount, hematocrit value (PCV), differential leucocyte counts and mean cell volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) were determined.Results: In diabetic rats, RBC, hemoglobin and hematocrit values were determined to be lower (p

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