Buzağılarda lokal ve sistemik inflamatuar durumun demir metabolizması ve lipit profili üzerine etkileri

Amaç: Bu çalışmanın amacı, buzağılarda lokal ve sistemik inflamatuar durumun demir metabolizması ve lipit profili üzerine etkilerinin belirlenmesidir. Gereç ve Yöntem: Çalışmada farklı ırk ve cinsiyette 39 hasta ve 17 sağlıklı olmak üzere toplam 56 buzağı kullanıldı. Has- ta buzağılar lokal (8 omfalit ve 11 artritis) ve sistemik (10 enterit ve 10 pnömoni) yangı olmak üzere 2 gruba ayrıldı. Tüm buzağıların rutin klinik muayeneleri yapıldıktan sonra kan analizleri için 8 ml kan alındı ve biyokimyasal analizleri yapıldı. Bulgular: Lokal ve sistemik yangılı buzağılarda serum demir, total kolesterol (TC), yüksek dansiteli lipoprotein (HDL) ve albümin düzeylerinin kontrol grubuna göre önemli düzeyde (p

The effects of local and systemic inflammatory status on iron metabolism and lipid profile in calves

Aim: The aim of this study was to determine the effects oflocal and systemic inflammatory status on iron metabolismand lipid profile in calves.Materials and Methods: A total of 56 calves, 39 sick and 17healthy, were used in the study in different races and gen-ders. The sick calves were divided into two groups as local (8omphalitis and 11 arthritis) and systemic (10 enteritis and10 pneumonia) inflammations. After routine clinical exami-nations of all the animals were performed, 8 ml of blood wastaken for blood analysis and biochemical analyses were per-formed.Results: Serum iron, total cholesterol (TC), high density li-poprotein (HDL) and albumin levels were significantly (p

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Alvarez C, Ramos A, 1986. Lipids, lipoproteins, and apopro- teins in serum during infection. Clin Chem, 32, 142-145.
Andreassen SM, Vinther AML, Nielsen SS, Andersen PH, et al., 2017. Changes in concentrations of haemostatic and inflammatory biomarkers in synovial fluid after intra-ar- ticular injection of lipopolysaccharide in horses. BMC Vet Res, 13, 182.
Astiz S, Gonzalez-Bulnes A, Elvira-Partida L, Perez-Villalobos N, et al., 2018. Bovine Neonatology, https://www.eolss. net/sample-chapters/C10/E5-15A-33.pdf Available: June 17, 2018.
Aydogdu U, Coskun A, Yildiz R, Guzelbektes H, et al., 2018. Clinical importance of lipid profile in neonatal calves with sepsis. J Hellenic Vet Med Soc, 69, 1189-1194.
Aydoğdu U, Coşkun A, Yıldız R, Güzelbekteş H, et al., 2018. Sistemik yangısal cevap sendromlu buzağılarda hematolo- jik parametreler ve serum demir düzeyindeki değişimler. Eurasian J Vet Sci, 34, 56-59.
Aygun O, Yildiz R, 2018. Evaluation of thrombomodulin and pentraxin-3 as diagnostic biomarkers in calves with sepsis. Vet Med, 63, 313-320.
Ayoglu H, Sezer U, Akin M, 2016. Selenium, copper, zinc, iron levels and mortality in patients with sepsis and systemic inflammatory response syndrome in Western Black Sea Region, Turkey. J Pak Med Assoc, 66, 447-452.
Barati M, Nazari MZ, Taher MT, Farhadi N, 2011. Comparison of lipid profile in septic and non-septic patients. Iran J Clin Infect Dis, 6, 144-147.
Basoglu A, Baspinar N, Tenori L, Hu X, et al., 2014. NMR based metabolomics evaluation in neonatal calves with acute diarrhea and suspected sepsis: A new approach for biomarker/s. Metabolomics, 4, 134.
Basoglu A, Sen I, Meoni G, Tenori L, et al., 2018. NMR-Based plasma metabolomics at set intervals in newborn da- iry calves with severe sepsis. Mediators Inflamm, 2018, 8016510.
Baydar E, Dabak M, 2014. Serum iron as an indicator of acute inflammation in cattle. J Dairy Sci, 97, 222-228.
Bermudes ACG, Carvalho WB, Zamberian P, Muramoto G, et al., 2017. Changes in lipid metabolism in paediatric pati- ents with severe sepsis and septic shock. Crit Care Med, 13, 688-691.
Bozukluhan K, Merhan O, Gokce HI, 2017. Alterations in lipid profile in neonatal calves affected by diarrhea. Vet World, 10, 786-789.
Castellheim A, Brekke OL, Espevik T, Harboe M, et al., 2009. Innate immune responses to danger signals in systemic inflammatory response syndrome and sepsis. Scand J Im- munol, 69, 479-491.
Ceron JJ, Eckersall PD, Martýnez-Subiela S, 2005. Acute phase proteins in dogs and cats: current knowledge and future perspectives. Vet Clin Pathol, 34, 85-99.
Cherayil BJ, 2011. The role of iron in the immune response to bacterial infection. Immunol Res, 50, 1-9.
Civelek T, Kav K, Camkerten I, Celik HA, et al., 2007. Effects of bacterial pneumonia in neonatal calves on serum lipids. Bull Vet Inst Pulawy, 51, 503-507.
Constable PD, Hinchcliff KW, Done SH, Grünberg W, 2017. Ve- terinary Medicine. A textbook of the diseases of cattle, hor- ses, sheep, pigs and goats. 11th ed, Saunders Ltd., Missouri.
Donovan GA, Dohoo IR, Montgomery DM, Bennett FL, 1998. Calf and disease factors affecting growth in female Holste- in calves in Florida, USA. Prev Vet Med, 33, 1-10.
Eckersall PD, Bell R, 2010. Acute phase proteins: Biomarkers of infection and inflammation in veterinary medicine. Vet J, 185, 23-27.
El-Bahr SM, EL-Deeb WM, 2013. Acute phase proteins, li- pid profile and proinflammatory cytokines in healthy and bronchopneumonic water buffalo calves. Am J Biochem Bi- otechnol, 9, 34-40.
Fitrolaki DM, Dimitriou H, Kalmanti M, Briassoulis G, 2013. CD64-Neutrophil expression and stress metabolic pat- terns in early sepsis and severe traumatic brain injury in children. BMC Pediatr, 13, 31.
Fitrolaki MD, Dimitriou H, Venihaki M, Katrinaki M, et al., 2016. Increased extracellular heat shock protein 90a in severe sepsis and SIRS associated with multiple organ fa- ilure and related to acute inflammatory-metabolic stress response in children. Medicine, 95, e 4651.
Gupta S, Jonas M, 2006. Sepsis, septic shock and multiple organ failure. Anaesthesia and Intensive Care Medicine, 7, 143-146.
Guzelbektes H, Coskun A, Sen I, 2007. Relationship between the degree of dehydration and the balance of acid-based changes in dehydrated calves with diarrhoea. Bull Vet Inst Pulawy, 51, 83-87.
Jain S, Gautam V, Naseem S, 2011. Acute-phase proteins: As diagnostic tool. J Pharm Bioallied Sci, 3, 118-27.
Joshi V, Gupta VK, Dimri U, Mandal RSK, et al., 2015. Serum lipid profile in bacterial Bovine Respiratory Disease (BRD) affected calves. Intas Polivet 16, 187-88.
Kirbas A, Kandemir FM, Celebi D, Hanedan B, et al., 2019. The use of inflammatory markers as a diagnostic and prognos- tic approach in neonatal calves with septicaemia. Acta Vet Hung, 67 (3), 360–376.
Lekkou A, Mouzaki A, Siagris D, Ravani I, et al., 2014. Serum lipid profile, cytokine production, and clinical outcome in patients with severe sepsis. J Crit Care, 29, 723-727.
Lorenz I, Mee JF, Earley B, More SJ, 2011. Calf health from birth to weaning. I. General aspects of disease prevention. Ir Vet J, 64, 10.
Nassaji M, Ghorbani R, 2012. Plasma lipid levels in patients with acute bacterial infections. Turk J Med Sci, 42, 465-469.
Schmidt EMS, Eckersall PD, 2015. Acute phase proteins as markers of infectious diseases in small animals. Acta Vet Beograd 65, 149-161.
Shanbhogue LK, Paterson N, 1990. Effect of sepsis and sur- gery on trace minerals. J Parenter Enteral Nutr, 14, 287- 289.
Sipahi T, Köksal T, Tavil B, Akar N, 2004. The effects of acute infection on hematological parameters. Pediatr Hematol Oncol J, 21, 511-518.
Srinivas U, Braconier JH, Jeppsson B, Abdulla M, et al., 1988. Trace element alterations in infectious diseases. Scand J Clin Lab Invest, 48, 495-500.
Torrente C, Manzanilla EG, Bosch L, 2015. Plasma iron, C-reactive protein, albumin, and plasma fibrinogen con- centrations in dogs with systemic inflammatory response syndrome. J Vet Emerg Crit Care (San Antonio), 25, 611- 619.
Yıldız R, Beslek M, Beydilli Y, Özçelik M, et al., 2018. Evalu- ation of platelet activating factor in neonatal calves with sepsis. Vet Hekim Der Derg, 89, 66-73.