Tuğba Melike PARLAK, Enver YAZAR, Amir NASERİ, Merve İDER, Aidai ZHUNUSHOVA

Koyunlara kombine antiprotozoal ilaç kullanımının güvenilirliği

Amaç: Bu çalışmanın amacı kan parazitlerine karşı kullanılan imido- karb, buparvaquon ve oksitetrasiklinin koyunlarda maksimum doz ve sürede kombine kullanımının olası yan etkilerini belirlemektir. Gereç ve Yöntem: Araştırmada 10 adet koyuna imidokarb (2.4 mg/ kg), buparvaquon (2.5 mg/kg) ve oksitetrasiklin (20 mg/kg) birlikte kas içi yolla 3 gün ara ile iki kez uygulandı. Kan örnekleri uygula- ma öncesi (0 kontrol) ve sonrası 0.5, 1, 2, 3, 4, 5 ve 6. günler alındı. Malondialdehid, 8-hidroksi-2-deoksiguanosin, troponin I ve kreatin kinaz-MB isoenzim düzeyleri ELISA okuyucusunda belirlenirken, kalp, karaciğer ve böbrek fonksiyon parametreleri otoanalizörde öl- çüldü. Ayrıca kan gazları ve hemogram parametreleri ölçüldü. Bulgular: Uygulama sonrası koyunlarda oksidatif stres belirlenmez- ken (p>0.05), laktat dehidrogenaz, aspartat aminotransferaz, alanin aminotransferaz, kan üre nitrojen ile glikoz düzeylerinde artışlar belirlendi (p

Safety of an antiprotozoal drug combination in sheep

Aim: The aim of this study was to determine the possible side effectsin sheep of combined administration of imidocarb, buparvaquone,and oxytetracycline, which are antiprotozoal drugs against bloodborne parasites, at the maximum dose and treatment period. .Materials and Methods: Imidocarb (2.4 mg/kg), buparvaquone(2.5 mg/kg), and oxytetracycline (20 mg/kg) were administered si-multaneously by intramuscular injection to 10 sheep, and a secondcombined dose was administered 3 days later. Blood samples weretaken before (0 control) and at 0.5, 1, 2, 3, 4, 5, and 6 days after drugadministrations. Malondialdehyde, 8-hydroxy-2′-deoxyguanosine,troponin I, and creatine kinase-MB isoenzyme levels were determi-ned with ELISA reader, and cardiac, hepatic, and renal damage mar-kers were measured with autoanalyzer. Blood gas and hemogramparameters were also determined.Results: No oxidative stress (p>0.05) was observed in the sheep,whereas increased (p

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