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• 1. Arsenault RJ, Li Y, Bell K, Doig K, Potter A, Griebel PJ, Kusalik A, Napper S, (2012). Mycobacterium avium subsp. paratuberculosis inhibits interferon gamma induced signaling in bovine monocytes: insights into the cellular mechanisms of Johne’s disease. Infect Immun. 80, 3039-3048. 2. Arsenault RJ, Li Y, Maattanen P, Scruten E, Doig K, Potter A, Griebel P, Kusalik A, Napper S, (2013). Altered Toll-like receptor 9 signaling in Mycobacterium avium subsp. paratuberculosis- infected bovine monocytes reveals potential therapeutic targets. Infect Immun. 1, 226-237. 3. Arsenault RJ, Maattanen P, Daigle J, Potter A, Griebel P, Napper S, (2014). From mouth to macrophage: mechanisms of innate immune subversion by Mycobacterium avium subsp. paratuberculosis. Vet Res. 45, 54. 4. Ayele WY, Machackova M, Pavlik I, (2001). The transmission and impact of paratuberculosis infection in domestic and wild ruminants. Vet Med-Czech. 46, 205-224. 5. Baquero MM, Plattner BL, (2016). Bovine WC1(+) γδ T lymphocytes modify monocyte-derived macrophage responses during early Mycobacterium avium subspecies paratuberculosis infection. Vet Immunol Immunopathol. 170, 65-72. 6. Basler T, Geffers R, Weiss S, Valentin-Weigand P, Goethe R, (2008). Mycobacterium avium subspecies induce differential expression of proinflammatory mediators in a murine macrophage model: evidence for enhanced pathogenicity of Mycobacterium avium subspecies paratuberculosis. Immunobiology. 213, 879-888. 7. Bassey EO, Collins MT, (1997). Study of T-lymphocyte subsets of healthy and Mycobacterium avium subsp. paratuberculosis- infected cattle. Infect Immun. 65, 4869-4872. 8. Begg DJ, de Silva K, Carter N, Plain KM, Purdie A, Whittington RJ, (2011). Does a Th1 over Th2 dominancy really exist in the early stages of Mycobacterium avium subspecies paratuberculosis infections? Immunobiology. 216, 840-846. 9. Behr MA, Kapur V (2008): The evidence for Mycobacterium paratuberculosis in Crohn’s disease. Curr Opin Gastroenterol. 24, 17-21. 10. Clarke CJ (1997): The pathology and pathogenesis of paratuberculosis in ruminants and other species. J Comp Pathol. 116, 217-261. 11. Collins MT, Wells SJ, Petrini KR, Collins JE, Schultz RD, Whitlock RH, (2005). Evaluation of five antibody detection tests for diagnosis of bovine paratuberculosis. Clin Diagn Lab Immunol. 12, 685-692. 12. Coussens PM, Verman N, Coussens MA, Elftman MD, McNulty AM, (2004). Cytokine gene expression in peripheral blood mononuclear cells and tissues of cattle infected with Mycobacterium avium subsp. paratuberculosis: evidence for an inherent proinflammatory gene expression pattern. Infect Immun. 72, 1409-1422. 13. Çetinkaya B, Muz A, Ertaş B, Öngör H, Sezen Y, Gülcü B, (2000). Süt ineklerinde paratüberküloz prevalansının polimeraz zincir reaksiyonu (PZR) ile saptanması. Turk J Vet Anim Sci. 24, 371-379. 14. Davis JM, Ramakrishnan L, (2009). The role of the granuloma in expansion and dissemination of early tuberculous infection. Cell. 136, 37-49. 15. de Almeida DE, Colvin CJ, Coussens PM, (2008). Antigenspecific regulatory T cells in bovine paratuberculosis. Vet Immunol Immunopathol. 125, 234-245. 16. Ellingson JLE, Anderson JL, Koziczkowski JJ, Radcliff RP, Sloan, SJ, Allen SE, Sullivan NM, (2005). Detection of viable Mycobacterium avium subsp. paratuberculosis in retail pasteurized whole milk by two culture methods and PCR. J Food Prot. 68, 966-972. 17. Gillan S, O’Brien R, Hughes AD, Griffin JF, (2010). Identification of immune parameters to differentiate disease states among sheep infected with Mycobacterium avium subsp. paratuberculosis. Clin Vaccine Immunol. 17, 108-117. 18. Kalis CH, Barkema HW, Hesselink JW, van Maanen C, Collins MT, (2002). Evaluation of two absorbed enzymelinked immunosorbent assays and a complement fixation test as replacements for fecal culture in the detection of cows shedding Mycobacterium avium subspecies paratuberculosis. J Vet Diagn Invest. 14, 219-224. 19. Khalifeh MS, Stabel JR, (2004). Effects of gamma interferon, interleukin-10, and transforming growth factor beta on the survival of Mycobacterium avium subsp. paratuberculosis in monocyte-derived macrophages from naturally infected cattle. Infect Immun. 72, 1974-82. 20. Lamont EA, (2012). Survival strategies of Mycobacterium avium subsp. paratuberculosis in a variety of microenvironments. PhD Thesis, The University of Minnesota, Minnesota, United States. 21. Lockhart E, Green AM, Flynn JL, (2006). IL-17 production is dominated by T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J Immunol. 177, 4662-4669. 22. Magombedze G, Eda S, Stabel J, (2015). Predicting the role of IL-10 in the regulation of the adaptive immune responses in Mycobacterium avium subsp. paratuberculosis infections using mathematical models. PLoS One. 10, e0141539. 23. Mallikarjunappa S, (2013). Cytokine gene expression in Holstein-Friesian and Jersey Calves infected with Mycobacterium avium subsp. paratuberculosis. Master Thesis. The University of Guelph, Ontario, Canada. 24. Nielsen SS, (2008a). Transtions in diagnostic tests used for detection of Mycobacterium avium subsp. paratuberculosis infections in cattle. Vet Microbiol. 132, 274-282. 25. Nielsen SS, Bjerre H, Toft N, (2008b). Colostrum and milk as risk factors for infection with Mycobacterium avium subspecies paratuberculosis in dairy cattle. J Dairy Sci. 91, 4610- 4615. 26. Plattner BL, Doyle RT, Hostetter JM, (2009). Gamma-delta T cell subsets are differentially associated with granuloma development and organization in a bovine model of mycobacterial disease. Int J Exp Pathol. 90, 587-597. 27. Robinson M, O’Brien R, Mackintosh C, Griffin F, (2008). Differential immune responses of red deer (Cervus elaphus) following experimental challenge with Mycobacterium avium subsp. paratuberculosis. Clin Vaccine Immunol. 15, 963- 969. 28. Roussey JA, Steibel JP, Coussens PM, (2014). Regulatory T cell activity and signs of T cell unresponsiveness in bovine paratuberculosis. Front Vet Sci. 1, 20. 29. Sanjuan MA, Milasta S, Green DR, (2009). Toll-like receptor signaling in the lysosomal pathways. Immunol Rev. 227, 203-220. 30. Secott TE, Lin TL, Wu CC, (2002). Fibronectin attachment protein is necessary for efficient attachment and invasion of epithelial cells by Mycobacterium avium subsp. paratuberculosis. Infect Immun. 70, 2670-2675. 31. Selvaraj P, Afsal K, Harishankar M, (2015). Vitamin D and macrophage functions in tuberculosis. Macrophage. 2, e756. 32. Sohal JS, Singh SV, Tyagi P, Subhodh S, Singh PK, Singh AV, Narayanasamyc K, Sheoran N, Komal Singh Sandhu, (2008). Immunology of mycobacterial infections: with special reference to Mycobacterium avium subspecies paratuberculosis. Immunobiology. 213, 585-598. 33. Sommer S, Pudrith CB, Colvin CJ, Coussens PM, (2009). Mycobacterium avium subspecies paratuberculosis suppresses expression of IL-12p40 and iNOS genes induced by signalling through CD40 in bovine monocyte-derived macrophages. Vet Immunol Immunopathol. 128, 44-52. 34. Tiwari A, VanLeeuwen JA, McKenna SL, Keefe GP, Barkema HW, (2006). Johne’s disease in Canada Part I: clinical symptoms, pathophysiology, diagnosis, and prevalence in dairy herds. Can Vet J. 47, 874-882. 35. Tizard IR, (2009). Veterinary Immunology, 8th edition, Saunders Elsevier, St. Louis, Missouri, p: 11-16. 36. Wadhwa A, Kumar N, Velasco-Villa A, Eda S, (2013). Overview of Johne’s disease immunology. Veterinary World. 6, 901-904. 37. Waters WR, Miller JM, Palmer MV, Stabel JR, Jones DE, Koistinen KA, Steadham EM, Hamilton J, Davis WC, Bannantine JP, (2003). Early induction of humoral and cellular immune responses during experimental Mycobacterium avium subsp. paratuberculosis infection of calves. Infect Immun. 71, 5130-5138. 38. Weiss DJ, Souza CD, (2008). Modulation of mononuclear phagocyte function by Mycobacterium avium subsp. paratuberculosis. Vet Pathol. 45, 829-841. 39. Whittington RJ, Windsor PA, (2009). In utero infection of cattle with Mycobacterium avium subsp. paratuberculosis: A critical review and meta-analysis. Vet J. 179, 60-69. 40. Woo SR, Czuprynski CJ, (2008). Tactics of Mycobacterium avium subsp. paratuberculosis for intracellular survival in mononuclear phagocytes. J Vet Sci. 9, 1-8. 41. Yardımcı H, (2006). Mycobacterium infeksiyonları. Editörler: Aydın N, Paracıkoğlu J. Veteriner Mikrobiyoloji, İlke-Emek Yayınları, Ankara, s: 87-107.