Caner KABASAKAL, Afig BERDELİ, Sevgi MİR

The interleukin-6-174 C allel is associated with early acute rejection in pediatric kidney allografts

lnterlökin-6 (IL-6) inflamasyon, konakçı savunması ve doku hasarında önemli rol oynayan çok işlevli bir sitokindir. Daha çok proinflamatuar sitokin olarak kabul edilmekle birlikte, son zamanlarda IL-6'nm immunsupressif rolü de saptanmıştır. Bu çalışmada, IL-6 -174 G/C promoter genotipinin, 55 böbrek nakli hastasından 14'ünde görülen akut rejeksiyona etkisi incelenmiştir. Akut rejeksiyon gözlenen 14 hastada, erken (ilk 3 ay içinde) akut rejeksiyon görülmesinin -174 C allel taşıyanlarda, taşımayanlara oranla anlamlı şekilde daha fazla olduğu bulunmuştur (%33,3 ile %10,3 p

Anahtar Kelimeler:

Böbrek nakli, İnterlökin-6, Böbrek, Gen çiftleri, Nakil, homolog, Polimorfizm, genetik, Sitokinler

Çocuk böbrek allograflarında erken akut rejeksiyon ile interlökin-6-174 C alleli ilişkilidir

lnterleukin-6 (IL-6) is a pleiotropic cytokine with a central role in inflammation, host defense and tissue injury. Although it is considered as predominantly proinflammatory cytokine; recently, IL-6 has been recognized as having additional immunosuppressive properties. In this study, we investigated the impact of IL-6 -174 G/C promoter genotype on acute rejection in 14 patients out of 55 kidney recipients. In 14 acute rejection presenting patients, early acute rejection (within first 3 months) was found significantly frequent in -174 C allel carriers, compared to non-carriers (33.3% vs 10.3% p<0.05). Our results imply a higher risk of early acute rejection in carriers of -174 C allel compared to non-carriers, and the relative risk of early acute rejection is 4.3 fold higher in IL-6 -174 C allel carrriers.

Keywords:

Kidney Transplantation, Interleukin-6, Kidney, Alleles, Transplantation, Homologous, Polymorphism, Genetic, Cytokines,

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