Ertan Pelin KARA, Kor YERELİ, HASAN ERHUN KASIRGA, Özgür KURT, Tamer ŞANLIDAĞ, Ali ONAĞ, Ahmet ÖZBİLGİN

The examination of link between blood levels of IGA, IGE, IGG, IGM, CRP and giardiasis in children

Giardiasis, Giardia lamblia'nin neden olduğu Türkiye'de çocuklar arasında yaygın olan intestinal protozoal bir enfeksiyondur. Bu çalışmada çocuklarda immunoglobulin A, E, G, M ve C-reaktif protein (CRP) ile giardiasis arasındaki ilişkiyi belirleme amaçlanmış. Bu nedenle native-lugol, formol etil asetat ve trikrom çoklaştırma yöntemlerinden en az biriyle dışkılarında Giardia Lamblia kist ve/veya trofozoiti saptanan 2-15 yaşları arasında 31 çocuk hasta grubu olarak kabul edilmiştir (HG). Aynı yaş grubundan sağlıklı 50 çocuk kontrol grubu (KG) kabul edilmişlerdir. Kan immunoglobulin ve CRP düzeyleri sırası ile ELISA ve agglütinasyon yöntemleri ile ölçülmüştür.Her iki grupta IgA düzeyleri normal sınırlar içinde bulunmuştur. HG'da (%38.7) ve KG'da (%16) olgunun IgE düzeylerinin normalin üzerinde olduğu saptanmıştır (p

Anahtar Kelimeler:

İmmunoglobulin A, Giardiaz, Çocuk, C-reaktif protein, İmmünglobulin G, İmmünoglobulin E

Çocuklarda giardiasis ile serum IGA, IGE, IGG, IGM ve CRP düzeyleri arasındaki ilişkinin incelenmesi

Giardiasis, an intestinal protozoan infection caused by Giardia lamblia, is common in Turkey, especially in children. This study was designed to determine the link between blood levels of immunoglobulins (Ig) of A, E, G, M and C-Reactive Protein (CRP) and giardiasis in children. A total of 31 children, aged between 2 and 15 years-old, whose stool samples were found to be positive for Giardia lamblia cysts and/or trophozoites by at least one method of saline-Lugol, formalin-ethyl acetate and trichrome staining, were enrolled in the study group (SG). The control group (CG) consisted of 50 age-matched healthy children. Blood levels of immunoglobulins and CRP were measured by ELISA and agglutination methods, respectively. IgA levels were found to be within normal range in all cases of both groups, the IgE levels were found over normal range in (38.7%) of SG and in (16%) of CG (p<0.05). However in (38.7%) of SG and in (2%) of CG IgG levels were found under normal range (p<0.05). In (32.25%) of SG and in (6%) of CG, the IgM levels were found higher than normal range (p<0.05). CRP levels were found over normal range in (25.8%) of SG and (4%) of CG (p<0.05). These results revealed a correlation between giardiasis and both increase in serum IgE, IgM and CRP levels and decrease in serum IgG levels. Specific components of IgA should be assessed instead of total serum IgA.

Keywords:

Immunoglobulin A, Giardiasis, Child, C-Reactive Protein, Immunoglobulin G, Immunoglobulin E,

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