Banu SARSIK, B DOĞANAVŞARGİL, D. BOZKURT, S. ŞEN

Beta-2 mikroglobulin amiloidozu (A$B_ 2$M) (diyalizle ilişkili amiloidoz)

Beta 2 mikroglobulin birikimine bağlı olarak ortaya çıkan diyaliz ile ilişkili amiloidoz, uzun dönem diyaliz hastalarında sık görülen komplikasyonlardan biridir. Beta 2 mikroglobulin, osteoartiküler dokularda özellikle de uzun kemiklerde ve sinovyal membranlarda birikme eğilimine sahiptir. Klinik bulgular karpal tünel sendromu, destrüktif artropati, kemik kistleri ve kırıkları içerir. Biz, klinik olarak kistik lezyonu ve destrüktif artropatisi gösterilen hastada, β2 mikroglobilin amiloidozu tanısını koyduk. Olgu, 15 yıldan daha uzun süredir kronik böbrek yetmezliği nedeni ile hemodiyaliz uygulanan 53 yaşında erkekti. Kongo kırmızısı boyama yöntemi ve β2 mikroglobulin immunhistokimyası; femur boynu patolojik kırığı nedeni ile alınan operasyon materyalinde yoğun β2 mikroglobulin birikimlerini gösterdi.

Beta-2 microglobulin amyloidosis (A$B_ 2$M) (dialysis related amyloidosis)

Dialysis-related amyloidosis secondary to β2 microglobulin deposition is a complication of long-term dialysis. Beta2 microglobulin has a tendency to deposit in the osteoarticular tissues, particularly in large bones and in synovial membranes. Clinical manifestations include carpal tunnel syndrome, destructive arthropathy, bone cysts and fractures. We diagnosed a patient with β2 microglobulin amyloidosis in whom cystic lesion and destructive arthropathy were clinically showed. The patient was a 53-year-old man who had been on hemodialysis for more than 15 years because of end-stage renal disease. Congo red staining and β2 microglobulin immunohistochemistry, showed extended β2 microglobulin deposits in the operation material was taken because of the pathological fracture of femur .

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