Özlem Devrim BALABAN, MURAT İLHAN ATAGÜN, Latif Ruhsat ALPKAN

Disülfirama bağlı olarak gelişen bir katatoni olgusu

Katatoni, sınıflandırma sistemlerinde daha çok şizofreninin bir alt grubu olarak değerlendirilmiş olsa da, birçok genel tıbbi durum, nörolojik hastalık ya da bazı ilaçlara bağlı olarak da ortaya çıkabilir. Disülfiram, alkol bağımlılığı tedavisinde caydırıcı etkisi nedeniyle kullanılabilen bir ajandır. Psikoz ve deliryum gibi nöropsikiyatrik yan etkilere neden olabilir. Katatonik sendrom disülfiramın çok nadir görülen bir yan etkisidir. Bu yazıda, kliniği bilişsel işlevlerde bozulma ile başlayan ve katatonik sendroma dönüşen bir vaka sunulmaktadır. Hastanın alkol kötüye kullanımı dışında psikiyatrik öyküsü yoktu ve son 1 aydır, reçetesiz temin ettiği disülfiramı kullanıyordu. Hastaya, disülfirama bağlı katatoni tanısı ile elektrokonvülsif tedavi uygulandı. Tam düzelme sağlanan ve ilaçsız izlenen vakanın iyilik hali devam etti. Bu çalışmada, örnek vaka çerçevesinde katatoni kavramı tartışılmaktadır.

A case of catatonia induced by disulfiram

Although catatonia has predominantly been evaluated as a subtype of schizophrenia, many of general medical conditions, some of neurological diseases or medications may cause catatonia. Disulfiram is an agent that is being used in the treatment of alcohol dependency by its aversive effect. It may cause neuropsychiatric side effects such as psychosis or delirium. Catatonic sydrome is a rare side effect of disulfiram. This paper aimed to report a case turning into catatonic syndrome following cognitive deterioration. The patient had no prior psychiatric history except alcohol abuse and was using disulfiram in the last month. With the diagnosis of “catatonia induced by disulfiram”, electroconvulsive therapy was applied. Full remission was obtained and the patient have been followed up without any medication. Concept of catatonia is discussed in this context.

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