Amaç: Demanslı hastalarda plazma bakır seviyeleri ve antioksidan enzimlerin aktivitelerini incelemek. Gereç ve Yöntem: Bu çalışmada 21 Alzheimer tipi demanslı (ATD: 17 erkek ve 4 kadın) ve 9 multi infarkt demansh (MİD: 5 erkek ve 4 kadın) toplam 30 olguda plazma bakır (Cu) dü-zeyleri ve eritrosit süperoksit dismutaz (CuZnSOD), glutatyon peroksidaz (GSH - Px) ve katalaz (ÇAT) aktiviteleri incelendi. Aynı yaş ve cinsiyette, demansı olmayan 33 kişi (21 erkek ve 12 kadın) seçilerek kontrol grubu oluşturuldu. Bulgular: ATD ve MID'li hastalar'da bakır düzeyleri ve GSH - Px aktivitelerini kontrol grubu ile karşılaştırıldıklarında aralarında fark bulunamadı (p>0,05) CuZnSOD ve katalaz aktiviteleri, kontrol grubuna göre artmış bulundu (p

Objective: We have investigated that the levels of plasma copper and the activites of antioxidant enzyme of the dementia patients. Material and Method: in this study, We have investigated that the levels of plasma copper and erythrocyte superoxide dismutase (CuZnSOD), glutatione peroxidase (GSH-Px) and catalase (ÇAT) in thirty patients (8 females, 22 males) with dementia vvhich 21 out of them with dementia of Alzheimer type (DAT) (4 females, 17 males) and 9 out of them \vith multiinfarct dementia (MD) (4 females, 5 males). Thirty three people (12 females, 21 males) that vvere not having demential complaints and not using an antkmdant vvere selected as a control group. Results: The plasma copper and erythrocyte GSH-Px levels vvere to be not changed vvhereas CuZnSOD and ÇAT levels were increased in both DAT and MD patient groups compared to control (p>0.05). in additional to this, increasing levels of CuZnSOD and ÇAT vvere found to be statistically significant (p<0.05). it has also been found that there vvere not relation between age and ali investigated parameters in both control and patient groups (p>0.05). Even though same directed correlation vvere noticed in control group, vvhile negative directed correlation in patient betvveen plasma copper level and erythrocyte CuZnSOD activity, but these correlations vvere not statiscally significan (p>0.05).