Over, Böbrek ve Beyinde İskemi / Reperfüzyon Sonrası Redoks Dengesi ve Tribulus Terrestris L.’nin Etkileri

Amaç: Oksidatif stres prooksidan ve antioksidan sistemler arasında oksidasyon lehine bir dengesizlik olarak tanımlanır ve iskemi / reperfüzyon hasarı gibi çeşitli patolojilerden sorumlu tutulmaktadır. Eksojen antioksidanlar redoks dengesinin geri kazanılmasında faydalıdırlar. Tribulusterrestris L. (demir dikeni) güçlü antioksidan etki sergileyen flavonoidler ve saponinler açısından zengin bir tıbbi bitkidir. Bu çalışma over, böbrek ve beyinde reperfüzyon hasarında Tribulus ekstresinin redoks dengesi üzerine etkilerini araştırmayı hedeflemiştir. Yöntemler: Dişi Wistar albino sıçanlaraTribulus veya fizyolojik salin uygulandı ve hayvanlar 60 dakika süreli over, böbrek ya da beyin iskemisini takip eden 60 dakika süreli reperfüzyona maruz bırakıldılar. Bahsedilen dokularda total antioksidan durum (TOS), total oksidan durum (TAS) ve oksidatif stres indeksi (OSI) belirlendi. Bulgular: Tribulus’un over, böbrek ve beyinde yalnızca reperfüzyon hasarı oluşturulan hayvanlara kıyasla TOS’u düşürdüğü bulundu (sırasıyla, p

Effects of Tribulus Terrestris L. and Post-Ischemia/Reperfusion Redox Balance in Ovaries, Kidneys, and Brain

Objective: Oxidative stress is defined as the imbalance in pro-oxidative and anti-oxidative systems in favor of oxidation, and it is held responsible for numerous pathologies including ischemia/reperfusion injury. Exogenous antioxidants are of benefit to the restoration of the redox balance. Tribulusterrestris L. (devil’s weed) is a medicinal herb, rich in flavonoids and saponins that exert strong anti-oxidant actions. The present study was aimed to investigate the effects of Tribulus extract on the redox balance in ovarian, renal and cerebral reperfusion injury. Method: Female Wistar albino rats were either received Tribulus or physiological saline and undergone to ovarian, renal or cerebral ischemia for 60 minutes followed by a 60-minute-long reperfusion. Total anti-oxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were estimated in the mentioned tissues. Results: Tribulus was found to reduce TOS in ovaries, kidneys and brain as compared with the animals in which only reperfusion injury was generated (respectively, p

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