Manyetik Rezonans Görüntüleme ile Yetişkinlerde İntrakranial Beyin-Omurilik Sıvısı Aralıklarının Ölçümü

Amaç: Ekstraaksiyel boşluklar olarak da bilinen intrakranial beyin-omurilik sıvısı (BOS) aralıkları süperfisyal serebral sulkus, Sylvian fissürler, bazal sisternalar; üçüncü, dördüncü ve her iki lateral ventrikülden oluşur. Çalışmamız, sağlıklı yetişkinlerde BOS aralıklarının lineer indekslerinin ölçülerek ortalama değerlerini belirlemeyi amaçlamaktadır. Yöntemler: Çalışmaya 20-50 yaş arası 300 olgu (150 erkek ve 150 kadın) dahil edildi. Manyetik rezonans görüntüleme (MRG) taramaları için 10 parametre kullanıldı: Sağ frontal subaraknoid aralığın maksimum genişliği, sol frontal subaraknoid aralığın maksimum genişliği, sağ Sylvian fissürün maksimum genişliği, sol Sylvian fissürün maksimum genişliği, ön interhemisferik fissürün maksimum genişliği, dördüncü ventrikül genişliği, dördüncü ventrikül indeksi, bifrontal indeks, bikaudat indeks ve Evans indeksi. BOS aralıklarının lineer ölçümleri ve lineer indeks ölçümlerinin olağan sınırları belirlendi. Bu ölçümlerden ortalamalar ve standart sapmalar (SS) hesaplandı. Tahminler milimetre olarak ifade edildi. Bulgular literatür ile karşılaştırıldı. Bulgular: Bikaudat indeks, sağ frontal subaraknoid aralığın maksimum genişliği ve sol Sylvian fissürün maksimum genişliği dışında, diğer parametrelerde erkekler ve kadınlar arasında istatistiksel olarak anlamlı bir fark yoktu (p>0.05). Erkekler ve kadınlar arasında, bikaudat indeks (p

Anahtar Kelimeler:

ntrakranial beyin omurilik sıvısı, lineer ölçümler, lineer ventriküler indeksler, yetişkin kişiler, manyetik rezonans görüntüleme

Retrospective Comparison of Chemotherapy Plus Anti-HER2 Therapies at First-line Treatment in Patients with Metastatic Gastric Adenocarcinoma

Aim: We aimed to compare the efficacy and the safety of cisplatin plus 5-FU plus trastuzumab and mFOLFOX-6 plus trastuzumab at first-line treatment in HER2-positive metastatic gastric cancer. Method: It was a retrospective observational monocentric study. Patients diagnosed with HER2-positive metastatic gastric adenocarcinoma between January 2013 and December 2020 in Dr AY Ankara Oncology TRH were screened. Patients treated at least one cycle of treatment with either CF-T or mFOLFOX-T were included. Survival outcomes and treatment compliance of patients were compared between groups. Results: Of 52 patients, 55.8% (n=29) of patients were treated with CF-T, and 44.2% (n=23) with mFOLFOX-T. The median age at diagnosis was 60 years (IQR: 52-70) in the CF-T and 64 years (IQR: 59-70) in the mFOLFOX-T groups. De novo metastatic disease comprised 96.6% (n=28) of patients in the CF-T and 69.6% (n=16) in the mFOLFOX-T groups (p=0.016). Both IHC3+ and ISH positivity were observed 82.8% (n=24) of patients in the CF-T and 56.5% (n=13) in mFOLFOX-T groups (p=0.038). The mPFS was 10.4 months (95% CI 8.7-12.2) in the CF-T and 6.5 months (95% CI 5.5-7.6) in the mFOLFOX-T groups (p=0.532). The mOS was 12.2 months (95% CI 11.3-13.2) in the CF-T and 12.5 months (95% CI 9.8-15.5) in the mFOLFOX-T groups (p=0.974). No statistically significant difference regarding at least one dose reduction (31.0% vs 21.7%, p=0.453) and at least one dose delay (24.1% vs 21.7%, p=0.838) was observed between groups. Conclusion: It was revealed that CF-T and mFOLFOX6-T had similar efficacy and tolerability in patients with HER2-positive metastatic gastric adenocarcinoma.

Keywords:

metastatic gastric cancer anti-HER2, FOLFOX, CF, FOLFOX, CF,

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