Isolated neuro-Behçet’s disease in a child, from headache to diagnosis: A case report
Isolated neuro-Behçet’s disease in a child, from headache to diagnosis: A case report
Behçet's disease (BD) is an immuno-inflammatory multi-systemic disease characterized by ophthalmological and skin involvement, also oral and genital ulcers. Its etiology and pathogenesis are not clearly known. Neuro-Behçet's disease can occur as an isolated form or a rare complication of BD. Besides, diagnosis of neuro-Behçet's disease is difficult. Since Neuro-Behçet can result in morbidity and mortality, early diagnosis and treatment are important. The most important genetic factor in the pathogenesis of BD is Human Leucocyte Antigen (HLA-B 51) allele positivity. A 9-year-old girl was brought to our outpatient clinic for 6 months with a migraine-like headache. The headache of the patient has a partial response to analgesics and rarely awakes from sleep at night accompanied by vomiting. The patient was diagnosed with an isolated neuro-Behçet's disease by HLA-B 51 allele positivity and brain magnetic resonance imaging (MRI) findings. In the current study, the roles of HLA-B 51 allele positivity and brain MRI findings were discussed in the diagnosis of neuro-Behçet's disease.
___
- 1.Behçet H. Uber residivierende, aphtosedurcheinVirus verursachte Geschwure am Mund, am Augeund an den Genitalien. DermWschr. 1937; 105:1152-57.
- 2. Saip S, Akman DG, Siva A. Neuro-Behçet syndrome. HandbClin Neurol. 2014; 121: 1703-23.
- 3.Knapp P. Beitragzur symptomatologie undtherapie der rezidivieren den hypopyoniritis undder begleiten denaphtozenschleimhauterkrankungen. Schweiz MedWochenschr. 1941; 71: 1288-90.
- 4.Davatchi F. Diagnosis/classification criteria forBehçet’s disease. Patholog Res Int. 2012; 2012:607921.
- 5.Gazioglu S, Boz M, Arıca DA, et al. Nöro-BehçetHastalığında Klinik Özellikler. Dicle Tıp Dergisi.2020; 47(2): 324-30.
- 6.Domaç FM, Boylu E, Mısırlı H, et al. Nöro-Behçetsendromlu olgularda kraniyal manyetik rezonansgörüntüleme bulguları. Türk Nöroloji Dergisi. 2010;16(1): 21-26.
- 7.Uluduz D, Kurtuncu M, Yapici Z, et al. Clinicalcharacteristics of pediatric-onset neuro-Behçetdisease. Neurology. 2011; 77: 1900-5.
- 8.Dao JM, Qubty W. Headache Diagnosis in Childrenand Adolescents. Curr Pain Headache Rep. 2018;22(3): 17.
- 9.Mohamed C, Najib K, Essaadouni L. Radiologicalfindings in Behçet disease. Pan Afr Med J. 2015; 20:51.
- 10.Koné-Paut I. Behçet's disease in children, anoverview. Pediatr Rheumatol Online J. 2016; 14(1):10.
- 11.Borhani-Haghighi A, Kardeh B, Banerjee S, et al.Neuro-Behcet's disease: An update on diagnosis,differential diagnoses, and treatment. MultSclerRelat Disord. 2019; 39: 101906.
- 12.Hamzaoui A, Houman MH, Massouadia M, et al.Contribution of Hla-B51 in the susceptibility andspecific clinical features of Behçet's disease inTunisian patients. Eur J Intern Med. 2012; 23(4):347-9.
- 13.Noel N, Bernard R, Wechsler B, et al. Long-termoutcome of neuro-Behçet's disease. ArthritisRheumatol. 2014; 66(5): 1306-14.