Seckin İLTER, Sabahattin ERTUGRUL, İbrahim DEGER, İbrahim KAPLAN

The Measurement of Neutrophil Gelatinase Associated Lipocalin in Umbilical Cord Blood and the Assessment of Its Relationship with Neonatal Results

Objectives: In this study, the relationship of cord blood Neutrophil Gelatinase-Associated Lipocalin (NGAL) with neonatal diseases was investigated. Methods: NGAL levels were measured in the cord blood of 180 babies born between 2015 and 2016. Patients were classified according to maternal diseases, neonatal diseases and demographic characteristics. Obtained data were compared with cord blood NGAL levels. Results: In our study, the mean NGAL levels were 1283.99 ng/mL in boys and 1306.52 ng/mL in girls. Umbilical cord blood NGAL levels of infants diagnosed with intrauterine growth retardation (1913.4±2833.5 ng/mL) and prolonged premature rupture of membranes (2594.2±2037.1 ng/mL) were found to be statistically high (p0.05). Conclusions: Neutrophil Gelatinase-Associated Lipocalin, may be useful as a diagnostic biomarker in the evaluation of maternal and neonatal diseases. However, studies on larger patient populations are needed.

Keywords:

Neutrophil Gelatinase Associated Lipocalin, umbilical cord blood, newborn,

PDF

___

1.American Society of Nephrology American Societyof Nephrology Renal Research Report. J Am SocNephrol 2005; 16: 1886–93.
2.Bellos, I., Fitrou, G., Daskalakis, G. et al. Neutrophilgelatinase-associated lipocalin as predictor of acutekidney injury in neonates with perinatal asphyxia: asystematic review and meta-analysis. Eur J Pediatr.2018; 177: 1425-34.
3.De Mul A, Parvex P, Wilhelm-Bals A. Neutrophilgelatinase-associated lipocalin distribution inpreterm newborns without acute kidney injury asdefined by a reference method. J Matern FetalNeonatal Med. 2021; 17; 1-5.
4.Parravicini E, Nemerofsky SL, Michelson KA, et al.Urinary neutrophil gelatinase-associated lipocalin is a promising biomarker for late onset culture-positive sepsis in very low birth weight infants.Pediatr Res. 2010; 67: 636-40.
5.Ertuğrul S, Annagur A, Kurban S, et al. Comparisonof urinary neutrophil gelatinase-associatedlipocalin, C-reactive protein and procalcitonin in thediagnosis of late onset sepsis in preterm newborns.J Matern Fetal Neonatal Med. 2013; 26: 430-3.
6.Inoue H, Ohga S, Kusuda T, et al. Serum neutrophilgelatinase-associated lipocalin as a predictor of thedevelopment of bronchopulmonary dysplasia inpreterm infants. Early Hum Dev. 2013; 89: 425-9.
7.Kisiel A, Roszkowska-Blaim M, Pańczyk-Tomaszewska M, et al. Effect of perinatal risk factorson neutrophil gelatinase-associated lipocalin(NGAL) level in umbilical and peripheral blood inneonates. Cent Eur J Immunol. 2017; 42: 274-80.
8.Medic B, Rovcanin B, Vujovic KS, et al. Evaluationof novel biomarkers of acute kidney injury: thepossibilities and limitations. Curr Med Chem. 2016;23: 1981-97.
9.Naunova-Timovska S, Cekovska S, Sahpazova E, etal. Neutrophil gelatinase-associated lipocalin as anearly biomarker of acute kidney injury in newborns.Acta Clin Croat. 2020; 59: 55-62.
10.Bellos I, Fitrou G, Daskalakis G, et al. Neutrophilgelatinase-associated lipocalin as predictor of acutekidney injury in neonates with perinatal asphyxia: asystematic review and meta-analysis.Eur J Pediatr.2018; 177: 1425-34.
11.Pynn JM, Parravicini E, Saiman L, et al. Urinaryneutrophil gelatinase-associated lipocalin: potentialbiomarker for late-onset sepsis. Pediatr Res. 2015;78: 76-81.
12.Murthy S, Godinho MA, Guddattu V, et al. Riskfactors of neonatal sepsis in India: A systematicreview and meta-analysis. PLoS One. 2019; 25; 14:e0215683.
13.Essajee F, Were F, Admani B. Urine neutrophilgelatinase-associated lipocalin in asphyxiatedneonates: a prospective cohort study. Pediatr Nephrol. 2015; 30: 1189-96.
14.Fiala M, Baumert M, Surmiak P, et al. Umbilicalmarkers of perinatal hypoxia. Ginekol Pol. 2016; 87:200-4.
15.Surmiak P, Baumert M, Fiala M, et al. Umbilicalcord blood NGAL concentration as an early markerof perinatal asphyxia in neonates. Ginekol Pol. 2014;85: 424-7.
16.Chen C-N, Chou C-H, Jeng S-F, et al. UrinaryNeutrophil Gelatinase-Associated Lipocalin Levelsin Neonates. Pediatr Neonatol. 2016; 57: 207-12.
17.Saeidi B, Koralkar R, Griffin RL, et al. Impact ofgestational age, sex, and postnatal age on urinebiomarkers in premature neonates. Pediatr Nephrol. 2015; 30: 2037-44.
18.Mikulić V, Rogić D, Mikulić I, et al. Urineneutrophil gelatinase-associated lipocalinconcentration in healthy newborns during the firstthree postnatal days. Biochem Med (Zagreb). 2020;15; 30: 030706.
19.Karampas G, Eleftheriades M, Panoulis K, et al.Maternal serum levels of neutrophil gelatinase-associated lipocalin (NGAL), matrixmetalloproteinase-9 (MMP-9) and their complexMMP-9/NGAL in pregnancies with preeclampsiaand those with a small for gestational age neonate: alongitudinal study. Prenat Diagn. 2014; 34: 726-33.