GÜLŞAH KANER, NİLGÜN SEREMET KÜRKLÜ, KÜBRA TEL ADIGÜZEL

Larenks Kanserinde Beslenmenin Rolü

Larenks kanseri, erişkinlerde tüm kanserlerin %2sini oluşturmakla birlikte baş boyun kanserlerinin en sık görülen türlerindendir. Ses kısıklığı, yutma güçlüğü, boğaz ağrısı gibi semptomlar veren larenks kanserinin gelişiminde sigara, alkol, yaş, cinsiyet, meslek, radyasyon, genetik, gastroözofageal reflü, diyet gibi zemin hazırlayan etmenler rol almaktadır. Kanser ile beslenme arasındaki ilk ilişki 960-1270 yılları arasında Yong-He Yang tarafından ortaya atılmıştır. Yapılan ilk araştırmalarda larenks kanserinin spesifik bir besin ögesi yetersizliğinden dolayı olmadığı gösterilmiştir. Sigara ve diğer tütün ürünlerinin kullanımının azaltılması, yeterli ve dengeli beslenmenin eğitim yoluyla yaygınlaştırılması larenks kanseri görülme sıklığını azaltacaktır. Larenks kanserinin görülme sıklığında meydana gelecek bir azalma, kurtarılan yaşam yılları ile birlikte kanser tedavisi maliyetlerinin azalmasına, toplumsal üretkenliğin ve refahın artmasına katkıda bulunacaktır. Bu derlemede larenks kanseri ile besin ögeleri arasındaki ilişki incelenmiştir.

The Role of Nutrition in Laryngeal Cancer

Larynx cancer, one of the most seen head and neck cancer types, accounts 2% of whole cancer cases in adults. Hoarseness, dysphagia and sore throat are the symptoms of the disease. Predisposing factors are smoking, alcohol, age, gender, occupation, radiation exposure, genetic factors, gastroesophageal reflux disease and nutritional factors. Between years 960-1270, association of cancer and nutrition was put forward firstly by Yong-He Yang. The first research studies on nutrition suggested that larynx cancer may not be due to the exposure of a specific food. Smoking cessation and promoting adequate and balanced nutrition via educational programmes could decrease the incidence of larynx cancer. This decrease could also lead to a prolongation of life expectancy, a decline in financial burdens due to cancer, an increase in the social productivity and welfare. In this paper, association between nutrients and larynx cancer is reviewed.

PDF

___

1.Elci OA, Elci MA, Blair A, Dosemeci M. Risk of laryngeal cancer by ocupational chemical exposure in Turkey. J Occup Environ Med 2003;45:1100-1106.
2.T.C. Sağlık Bakanlığı, Kanserle Savaş Dairesi Başkanlığı. Türkiyede Kanser Kontrolü 2009, Ankara.
3.Filho VW. The epidemiology of laryngeal cancer in Brazil. Sao Paulo Med J 2004;122(5):188-194.
4.Rosai J. Respiratory tract. Rosai and Ackermans Surgical Pathology. China: Elsevier 2004:335-359.
5.Dosemeci M, Gokmen I, Unsal M, Hayes RB, Blair A. Tobacco, alcohol use, and risks of laryngeal and lung cancer by subsite and histologic type in Turkey. Cancer Causes Control 1997;8:729-737.
6.Koufman JA, Burke AJ. The etiology and pathogenesis of laryngeal carcinoma. Otolaryngol Clin North Am 1997;30:1-19.
7.El-Serag HB, Hepworth EJ, Lee P, Sonnenberg A. Gastroesophageal reflux disease is a risk factor for laryngeal and pharyngeal cancer. Am J Gastroenterol 2001;96(7):2013-2018.
8.Licitra L, Bernier J, Grandi C, Locati L, Merlano M, Gatta G, et al. Cancer of larynx. Crit Rev Oncol Hematol 2003;147:65-80.
9.World Cancer Research Fund/American Institute for Cancer Research. Food, nutrition, physical activity and the prevention of cancer: a global perspective. 2007, Washington DC: AICR.
10.Boyle P, Autier P, Bartelink H, Baselga J, Boffetta P, Burn J, et al. European Code Against Cancer and scientific justification: third version (2003). Ann Oncol 2003;14(7):973-1005.
11.Bosetti C, La Vecchia C, Talamini R, Negri E, Levi F, Dal Maso L, et al. Food groups and laryngeal cancer risk: a case-control study from Italy and Swıtzerland. Int J Cancer 2002;100:355-360.
12.Bosetti C, La Vecchia C, Talamini R, Negri E, Levi F, Fryzek J, et al. Energy, macronutrients and laryngeal cancer risk. Ann Oncol 2003;14:907-912.
13.Pelucchi C, Talamini R, Levi F, Bosetti C, La Vecchia C, Negri E, et al. Fibre intake and laryngeal cancer risk. Ann Oncol 2003;14:162-167.
14.Bidoli E, Bosetti C, La Vecchia C, Levi F, Parpinel M, Talamini R, et al. Micronutrients and laryngeal cancer risk in Italy and Switzerland: a case-control study. Cancer Causes Control 2003;14(5):477-484.
15.Roy SS, Mukherjee S, Mukhopadhyay S, Salil K, Das SK. Differential effect of cadmium on choline phosphotransferase activity in normal and cancer us human mammary epithelial cell lines. Mol Cancer Ther 2004;3(2):199-204.
16.Agudo A, Cabrera L, Amiano P, Ardanaz E, Barricarte A, Berenguer T, et al. Fruit and vegetable intakes, dietary antioxidant nutrients, and total mortality in Spanish adults: Findings from the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Spain). Am J Clin Nutr 2007;85(6):1634-1642.
17.Boeing H, Dietrich T, Hoffman K, Pischon T, Ferrari P, Lahmann PH, et al. Intake of fruits and vegetables and risk of cancer of the upper aero-digestive tract: the prospective EPIC-study. Cancer Causes Control 2006;17(7):957-969.
18.Russo GL. Ins and outs of dietary phytochemicals in cancer chemoprevention. Biochem Pharmacol 2007;74:533-544.
19.Frankenfeld CL, Cerhan JR, Cozen W, Davis S, Schenk M, Morton LM et al. Dietary flavonoid intake and non- Hodgkin lymphoma risk. Am J Clin Nutr 2008;87:1439- 1445.
20.Romagnolo DF, Selmin OI. Flavonoids and cancer prevention: A review of the evidence. Journal of Nutrition in Gerontology and Geriatrics 2012;31(3):206- 238.
21.Millen AE, Subar AF, Graubard BI, Peters U, Hayes RB, Weissfeld JL, et. al. Fruit and vegetable intake and prevalence of colorectal adenoma in a cancer screening trial. Am J Clin Nutr 2007;86:1754-1764.
22.Key TJ, Appleby PN, Allen NE, Travis RC, Andrew W, Roddam AW, et. al. Plasma carotenoids, retinol, and tocopherol sand the risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition study. Am J Clin Nutr 2007;86:672-681.
23.Sorice A, Guerriero E, Capone F, Colonna G, Castello G, Costantini S. Ascorbic acid: its role in immune system and chronic inflammation diseases. Mini Reviews in Medicinal Chemistry 2014;14(5):444-452.
24.Gonzalez MJ, Miranda-Massari JR. Anticancer Mechanisms of vitamin C. New Insights on Vitamin C and Cancer . Springer Briefs in Cancer Research 2014:17-26.
25.Riboli E, Kaaks R, Esteve J. Nutrition and laryngeal cancer. Cancer Causes and Control 1996;7:147-156.
26.Kapil U, Singh P, Bahadur S, Nand Dwivedi S, Singh R. Assessment of risk factors in laryngeal cancer in India: A case- control study. Asian Pacific J Cancer Prev 2005;6:202-207.
27.Block G. Vitamin C and cancer prevention: the epidemiologic evidence. Am J Clin Nutr 1991;53:270S-282S.
28.Poppel G, Berg H. Vitamins and cancer. Cancer Letters 1997;114:195-202.
29.Bidoli E, Bosetti C, La Vecchia C, Levi F. Micronutrients and laryngeal cancer risk in Italy and Switzerland: a case-control study. Cancer Causes and Control 2003;14:477484.
30.Gök Ü, Tazegül A. Larenks epidermoid kanserinde vitamin A düzeyi. Fırat Tıp Dergisi 2005;10(2):45-47.
31.Keszeia AP, Schoutena LJ, Driessena ALC, Huysentruyta CJR, Keulemansa YCA, Goldbohma RA, et al. Vegetable, fruit and nitrate intake in relation to the risk of Barretts oesophagus in a large Dutch cohort. Br J Nutr 2014;111(8):1452-1462.
32.Deneo-Pellegrini H, Boffetta P, De Stefani E, Correa P, Ronco AL, Acosta G, et al.Nutrient-based dietary patterns of head and neck squamous cell cancer: a factor analysis in Uruguay. Cancer Causes & Control 2013;24(6):1167-1174.
33.Attilioa G, Robertoc B, Luigid B, Piersl G, Vincenzoe G, Jaakn J, et al. Cancer prevention in Europe: the Mediterranean diet as a protective choice. Eur J Cancer Prevention 2013;22(1):9095.
34.Bosetti C, Gallus S, Trichopoulou A, Talamini R, Franceschi S, Negri E, et al. Influence of the Mediterranean diet on the risk of cancers of the upper aerodigestive tract. Cancer Epidemiol Biomarkers Prev 2003;12:1091-1094.
35.Chatenoud L, La Vecchia C, Franceschi S, Tavani A, Jacobs DR Jr, Parpinel MT, et al. Refined-cereal intake and risk of selected cancers in Italy. Am J Clin Nutr 1999;70:1107-1110.
36.Esteve J, Riboli E, Péquignot G, Estève J, Riboli G, Terracini B, et al. Diet and cancers of the larynx and hypopharynx: the IARC multi-center study in southwestern Europe. Cancer Causes and Control 1996;7:240-252.
37.Kjærheim K, Gaard M, Andersen A. The role of alcohol, tobacco and dietary factors in upper aerogastric tract cancers: a prospective study of 10,900 Norwegian men. Cancer Causes and Control 1998;9:99-108.
38.Pelucchi C, Talamini R, Levi F, Bosetti C. Fibre intake and laryngeal cancer risk. Ann Oncol 2003;14:162-167.
39.Donaldson MS. Nutrition and cancer: A review of the evidence for an anti-cancer diet. Nutr J 2004;3:1-21.
40.Riboli E, Norat T. Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am J Clin Nutr 2003;78:559S569S.
41.Lucenteforte E, Garavello W, Bosetti C, Vecchia CL. Dietary factors. Olshan AF (Ed.) Cancer of the Oral Cavity and Pharynx. Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer. London:Springer; 2010;117-137.
42.Galeone C, Pelucchi C, Levi F, Negri E, Franceschi S, Talamini R, et al. Onion and garlic use and human cancer Am J Clin Nutr 2006;84:1027-1032.
43.Bosetti C, Talamini R, Levi F, Negri E, Franceschi S, Airoldi L, et al. Fried foods: a risk factor for laryngeal cancer? Br J Cancer 2002;87:1230-1233.
44.De Stefani E, Ronco AL, Mendilaharsu M, Deneo- Pellegrini H. Diet and risk of cancer of the upper aerodigestive tractII. Nutrients. Oral Oncol 1999;35:2226.
45.Rossi M, Garavello W, Talamini R, Negri E, Bosetti C, Dal Maso L, et al. Flavonoids and the risk of oral and pharyngeal cancer: A case-control study from Italy. Cancer Epidemiol Biomark Prev 2007,16:16211625.
46.Ide R, Fujino Y, Hoshiyama Y, Mizoue T, Kubo T, Pham TM, et al. A prospective study of green tea consumption and oral cancer incidence in Japan. Ann Epidemiol 2007;17:821826.
47.Bosetti C, La Vecchia C, Talamini R, Simonato LE, Zambon P, Negri E, et al. Foods groups and risk of squamous cell esophageal cancer in Northern Italy. Int J Cancer 2000;87:289-294.
48.Orellana C. Meat consumption and laryngeal cancer in Uruguay. Lancet Oncol 2001;2:257-261.
49.Gallus S, Bosetti C, Francescho S, Levi F, Negri E, La Vecchia C. Laryngeal cancer in women. Tobacco, alcohol, nutritional and hormonal factors. Cancer Epidemiol Biom Prev 2003;12:514-517.
50.Garavello W, Lucenteforte E, Bosetti C, La Vecchia C. The role of foods and nutrients on oral and pharyngeal cancer risk. Minerva Stomatol 2009;58:25-34.