Diyabette Krom ve Magnezyumun Rolü

Diabetes mellitus (DM), dünyada hızla artış gösteren hastalıklardan biridir. Krom karbonhidrat metabolizması için elzem bir besin ögesidir. Krom desteğinin glukoz metabolizmasını iyileştirdiği yapılan birçok çalışmada gösterilmiştir. Bununla birlikte, kromun olası etkileri hakkında karışıklık devam etmektedir. Diyabet ile ilişkili bir diğer besin ögesi magnezyumdur. Epidemiyolojik çalışmalar diyabetik hastalarda yüksek hipomagnezemi prevelansı olduğunu göstermektedir. Magnezyum insülin aktivitesinde önemli bir rol oynamaktadır. Çalışmaların çoğunda magnezyum alımı ile diyabet riski arasında ters ilişki bulunmuştur.

The Role of Chromium and Magnesium in Diabetes

Diabetes is one of the fastest growing diseases in the world. Chromium is an essential nutrient for carbohydrate metabolism. Chromium supplementation has been shown to improve glucose metabolism in many of the studies. However, concern exists about the possible effects of chromium. Magnesium is an another nutrient which is associated with diabetes. Epidemiologic studies showed a high prevalence of hypomagnesamia in diabetic patients. Magnesium plays an important role in insulin activitiy. An inverse association between magnesium intake and risk of diabetes has been found in many of studies.

___

  • 1.Hummel M, Schnell O. Clinical studies on chromium suplementation in diabetes mellitus. Curr Top Nutraceutical Res 2009;7:1-10.
  • 2.Polley G, Pandit S, Pra Tip D, Somoresh M, Biswajit A, Banarjee D, et al. Effects of adjunct therapy of a proprietaryherbo-chromium supplement in type 2 diabetes: A randomized clinical trial. Int J Diab Dev Ctries 2010;30(3):153-161.
  • 3.Chaudhary PD, Sharma R, Bansal DD. Implications of magnesium deficiency in type 2 diabetes: a review. Biol Trace Elem Res 2010;134:119-129.
  • 4.Davi G, Santilli F, Patrona C. Nutraceuticals in diabetes and metabolic syndrome. Cardiovasc Ther 2010;28:216- 226.
  • 5.Balk ME, Tatsioni A, Lichtentein HA, Lau J, Pittas GA. Effect of chromium supplementation on glucose metabolism and lipids. Diab Care 2007;30:2154-2163.
  • 6.Cefalu TW, Rood J, Pinsonat P, Newcomer B, Wang QZ, Martin KC, et al. Characterization of the metabolic and physiologic response to chromium supplementation in subjects with type 2 diabetes mellitus. Metabolism 2010;59:755-762.
  • 7.Sharma S, Agarwal PR, Choudhary M, Jain S, Goyal S, Agarwal V. Beneficial effect of chromium supplementation on glucose, HbA1c and lipid variables in individuals with newly onset type-2 diabetes. J Trace Elem Biol 2011;25:149-153.
  • 8.Wang QZ, Qin J, Martin J, Zhang HX, Serada O, Anderson AR, et al. Phenotype of subjects with type 2 diabetes may determine clinical response to chromium supplementation. Metabolism 2007;56:1652-1655.
  • 9.Ghosh D, Mukherjee B, Manna B, Sinha M, Bhattacharya B, Chowdhury J. Role of chromium supplementation in Indians with type 2 diabetes mellitus. J Nutr Biochem 2002;13:690-697.
  • 10.Geohas J, Daly A, Juturu V, Fınch M, Komorowski RJ. Chromium picolinate and biotin combination reduce satherogenic index of plasma in patients with type 2 diabetes mellitus: a placebo controlled, double blinded, randomized clinical trial. Am J Med Sci 2007;333(3):145-153.
  • 11.Sandhu K, Sachdeva R. Efficacy of chromium supplementation and nutrition counseling on glysemic index and lipid profile in male NIDDM patients. J Hum Ecol 2011;35(3):181-187.
  • 12.Lai HM. Antioxidant effects and insulin resistance improvement of chromium combined with vitamin C and E supplementation for type 2 diabetes mellitus. J Clin Biochem Nutr 2008;43:191-198.
  • 13.Jain KS, Kahlon G, Morehead L, Dhawan R, Caltido G, Lieblong B,et al. Effect of chromium dinicocysteinate supplementation on circulating levels of insülin, TNF- α,oxidative stres, and insulin resistance in type 2 diabetic subjects: randomized, double blind, placebo controlled study. Mol Nutr Food Res 2012;56:133-1341.
  • 14.Albarracin AC, Fuqua CB, Evans LJ, Goldfine DI. Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes. Diabetes Metab Res Rev 2008;24:41-51.
  • 15.Hua Y, Clark S, Ren J, Sreejayan N. Molecular mechanisms of chromium in alleviating insulin resistance. J Nutr Biochem 2012;23:313-319.
  • 16.Kleefstra N, Bakker SJ, Verhoven S, Houweling ST, Jong MB, Gans RO. Chromium treatment has no effect in patients with type 2 diabetes in a western population. Diab Care2007;30(5):1092-1096.
  • 17.Kleefstra N, Bakker SJ, JansmanFG , Gronier KH, Gans RO, Houweling ST, et al. Chromium treatment has no effect in patients with poorly controlled, insulin treated type 2 diabetes in an obese western population. Diab Care 2006;29:521-525.
  • 18.Gunton JE, Cheung NW, Hitchman R, Hams G, O Sullivan C, Mcelduff A, et al. Chromium supplementation does not improve glucose tolerance, insulin sensitivity, or lipid profile: a randomized, placebo controlled, double blind trial of supplementation in subjects with impaired glucose tolerance. Diab Care 2005;28:712-713.
  • 19.Anderson RA, Cheng N, Bryden NA, Polansky MM, Chi J, Feng J. Konu adı??? Diabetes 1997;46:1786- 1791.
  • 20.Baysal A. Beslenme. 10. Baskı. Hatiboğlu Yayınevi, Ankara,2004.
  • 21.Ed. Baysal A, Aksoy M, Bozkurt N, Pekcan G, Mercanlıgil SM, Yıldız E ve arkadaşları. Diyet El Kitabı. 5. Baskı, Hatiboğlu Basım ve yayım San. Tic. Ltd. Şti. Ankara 2011. Yazarı ve konu adı
  • 22.American Diabetes Association. Nutrition recommendations and interventions for diabetes (Position Statement). Diab Care 2007;30(1):48-65.
  • 23.Barbagallo M, Dominguez LJ. Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance. Arch Biochem Biophys 2007;458:40- 47.
  • 24.Kirii K, Iso H, Date C, Fukui M, Tamakoshi A. Magnesium intake and risk of selfreported type 2 diabetes among Japanese. J Am Coll Nutr 2010;29:99- 106.
  • 25.Villegas R, Gao YT, Dai Q, Yang G, Cai H, Li H, et al. Dietary calcium and magnesium intakes and risk of type 2 diabetes: the Shanghai Women’s health study. Am J Clin Nutr 2009;89:1059-1067.
  • 26.Hopping BN, Erber E, Grandinetti A, Verheus M, Kolonel LN, Maskarinec G. Dietary fiber, magnesium, and glycemic load alter risk of type 2 diabetes in a multi ethnic cohort in Hawai. J Nutr 2010;140:68-74.
  • 27.Larson SC, Wolk A. Magnesium intake and risk of type 2 diabetes: a meta-analysis. J Intern Med 2007;262:208- 214.
  • 28.McKeown NM, Jacques PF, Zhang XL, Juan W, Sahyoun NR. Dietary magnesium intake is related to metabolic syndrome in older Americans. Eur J Nutr 2008;7:210-216.
  • 29.Nanri A, Mizoue T, Noda M, Takahashi Y, Kirii K, Inoue M, et al. Magnesium intake and type 2 diabetes in Japanese men and women: the Japan public health center based prospective study. Eur J Clin Nutr 2010;64:1244- 1247.
  • 30.Schulze MB, Heidemann C, Schienkiewitz A, Hoffman K, Boeing H, Schulz M. Fiber and magnesium intake and incidence of type 2 diabetes. Arch Intern Med 2007;167:956-965.
  • 31.Viktorinova A, Toserova E, Krizko M, Durackova Z. Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus. Metabolism 2009;59:1477-1482.
  • 32.Halaçoğlu A, Suher M. Diyabetes mellitus regülasyonunun serum eser elementleri ilişkisi. Yeni Tip Dergisi 2012;29(1):47-49.
  • 33.Maan MA, Sheikh MA, Nawaz H, Jamil A, Hussein F. Trace element status in type 2 diabetes. BJMS 2009;8(3):52-56.
  • 34.Masood N, Baloch GH, Ghori RA, Memon IA, Memon MA, Memon MS. Serum zinc and magnesium in type 2 diabetic patients. J Coll Physicians Surg Pak 2009;19(8):483-486.
  • 35.Dong JY, Xun P, He K, Qin LQ. Magnesium intake and risk of type 2 diabetes. Diab Care 2011;34:2116-2122.
  • 36.Bo S, Pisu E. Role of dietary magnesium in cardiovascular disease prevention, insulin sensitivity and diabetes. Curr Opin Lipidol 2008;19:50-56.
  • 37.Thomas T, Pfeifffer AFH. Foods for the prevention of diabetes: how do they work? Diabetes Metab Res Rev 2012;28:25-49.
  • 38.Ma B, Lawson AB, Liese AD. Dairy magnesium and calcium intake in relation to insulin sensitivity: approaches to modeling a dose-dependent association. Am J Epidemiol 2006;164:449-458.
Beslenme ve Diyet Dergisi-Cover
  • ISSN: 1300-3089
  • Yayın Aralığı: Yılda 3 Sayı
  • Başlangıç: 1972
  • Yayıncı: Türkiye Diyestisyenler Derneği