Hafif-Orta Hiperlipidemili Bireylerde Bitkisel Stanol İçeren Yoğurdun Serum Lipid Profiline Etkileri

Amaç: Bu çalışma hafif-orta hiperlipidemili yetişkinlerde bitkisel stanol ester içeren az yağlı yoğurdun serum lipitleri üzerindeki etkinliğini değerlendirmek amacıyla yapılmıştır. Bireyler ve Yöntem: Plasebo kontrollü, çift kör, randomize çalışma dizaynı kullanılmıştır. Toplam 70 hafif-ortahiperlipidemili birey çalışmaya katılmış ve katılımcılar randomizasyon tablosuna göre bitkisel stanol grubu veya kontrol grubuna ayrılmışlardır. Bitkisel stanol grubunda yer alan katılımcılar dört hafta süresince her gün 1.9 g bitkisel stanol ester içeren az yağlı yoğurt (115 gram) tüketirken, kontrol grubunda yer alan katılımcılar aynı miktarda bitkisel stanol içermeyen az yağlı yourt tüketmişlerdir. Kan örnekleri başlangıçta, 2. 3. ve 4. haftanın sonunda alınmış ve lipid profili parametreleri analiz edilmiştir. Bulgular: Dört haftalık müdahale dönemi sonunda bitkisel stanol esteri eklenmiş yoğurt tüketenlerde total ve düşük yoğunluklu lipoprotein (LDL) kolesterol düzeylerinin sırasıyla %4.6 ve %6.3 oranında azaldığı ve bu değişimin istatistiksel ve klinik açıdan önemli olduğu bulunmuştur (p0.05). Sonuç: Hafif-ortahiperlipidemili bireylerde total ve LDL kolesterol düzeylerini düşürebilmek için, bitkisel stanol eklenmiş az yağlı süt ürünlerinin diyete eklenmesi yararlı olabilir.

Effects of Yoghurt with Plant Stanols on Serum Lipid Profile in Patients with Mild to Moderate Hyperlipidemia

Aim: The aim of this study was to examine the effects of low fat yoghurt with plant stanols as esters on serum lipids in subjects with mild to moderate hyperlipidemia. Subjects and Methods: A parallel, randomised, double-blind study design was used. In total, 70 mildly to moderately hypercholesterolaemic subjects participated and they were randomly divided into two groups: a plant stanol ester group and a control group. The subjects in plant stanol ester group consumed low-fat yoghurt with 1.9 g plant stanols as esters (115 g) daily for 4 weeks where as subjects in control group consumed same amount of low fat yoghurt with outplant stanols as esters. Blood samples were collected at baseline, end of second, third and fourth week of intervention and the parameters of lipid profiles were analysed. Results: Four weeks intake of 1.9 g/d plant stanols as esters lowered total and LDL cholesterol levels by 4.6% and 6.3%, respectively (p<0.05). There was no change in serum high-density lipoprotein (HDL) cholesterol or triacylglycerol concentrations (p>0.05). Conclusion: Low fat dairy products with plant stanols as esters might be useful tools to reduce serum total and LDL cholesterol levels in mildly or moderately hypercholesterolemic individuals to prevent more severe hypercholesterolemia.

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