Öz Novel FT-Raman methods for the quantitative analysis of fenthion, diazinon, methyl-parathion, ciprofloxacin and acyclovir are presented along their evaluation in the analysis of their formulations. The proposed methods provide results that are in accordance with those obtained through standard methods. Multivariate calibration provides results that are in accordance with those obtained through univariate calibration for all methods except for methyl-parathion where the accuracy is improved by multivariate calibration. Furthermore, the proposed methods offer several advantages compared to spectroscopic and chromatographic methods