Öz Methods for trace elements determination in wine by electrothermal atomic absorption spectrometry (ETAAS) directly in untreated wines and in previously decomposed wines are given. The investigations on the atomization behaviour of the microelements in wine, on the reasons for strong wine matrix interferences, on the accuracy of the calibration procedures are presented. Appropriate procedures for preliminary separation and preconcentration of ultra trace elements from wine matrix are compared and discussed. Optimal analytical methods for direct ETAAS determination of As, Cd, Cr, Ni, Pb and extraction ETAAS determination of Se, Tl are developed and validated. Results for the content of trace elements in Macedonian and Bulgarian wines are presented