Mine ERİŞİR, Ahmet ÖZKAYA, Fulya BENZER, Üzeyir DAĞ

Kurşun Uygulanan Ratların Bazı Dokularında (Kalp, Akciğer, Beyin, Dalak, Kas) Oksidatif Stress Üzerine Naringeninin Etkisi

Naringenin oksidatif strese karşı direnci artıran bir flavonoiddir. Bu çalışmada kurşun maruziyeti ile ratların kalp, akciğer, beyin,dalak ve kas dokularında lipid peroksidasyon ve bazı antioksidanların ayrıca bu parametreler üzerine naringeninin etkisininaraştırılması hedeflendi. Naringenin 50 mg/kg dozda mısır yağında çözülerek orogastrik sonda ile kurşun asetat ise günlük 500 ppm olacak sekilde içme suyuna karıştırılarak 4 hafta boyunca verildi. Kurşuna maruz kalan ratların beyin, akciğer, dalak ve kas dokularının MDA düzeylerinde istatistik olarak anlamlı artış (P0.05). Kurşun uygulaması beyin, dalak, kas dokusunda GSH-Px aktivitesinde, kalp, akciğer ve kas dokusunda CAT aktivitesinde, akciğer ve kas dokusunda ise GSH konsantrasyonunda istatistik olarak önemli azalmalara sebep oldu (P

The Effect of Naringenin on Oxidative Stress in Some Tissues (Heart, Lung, Brain, Spleen, Muscle) of Lead-treated Rats

Naringenin, a flavonoid increases resistance against oxidative stress. The present study aims to investigate the effect of lead on lipid peroxidasyonu and some antioxidants in heart, lung, brain, spleen, muscle and the effect of naringenin on these parameters. Naringenin was administered by orogastric gavage (50 mg/kg, dissolved in corn oil) and lead acetate was given as daily 500 parts per million in drinking water for 4 weeks. In the rats exposed to lead, MDA levels in the brain, lungs, spleen and muscle tissues significantly increased (P0.05). Lead caused a statistically significant decrease in GSH-Px activity of the brain, spleen and muscle tissues, in CAT activity of the heart, lung and muscle tissues, in GSH concentration of the lungs and muscle tissues (P

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