İbrahim Mert POLAT, Hatice Esra ÇOLAKOĞLU, Murat Onur YAZLIK, Ekrem Çağatay ÇOLAKOĞLU

Evcil Hayvanlarda Operasyon Sonrası Rifamisin Nedenli Hayati Hipersensitivite Reaksiyonları: 7 Olgunun Değerlendirilmesi

İlaç nedenli hipersensitivite ve yüksek mortalite ile ilişkili yan etkiler veteriner hekimler için halen büyük bir sorun teşkil etmektedir. Her ne kadar veteriner pratikte intradermal duyarlılık testi olmaksızın yara sağaltımında Rifamisin SV uygulaması yaygın şekilde kullanılsa da konuyla ilgili literatür veri bulunmamaktadır. Sunulan olgularda, kedi (n=3) ve köpeklerin (n=4) meme bezlerinde bulunan neoplastik kitleler mastektomi operasyonu ile uzaklaştırıldı. Rifamisin SV’nin subkutanöz uygulaması intra ve post operatif olarak yapıldı. Rifamisin SV’nin multipl subkutanöz kullanımı sonrasında yüz ve dil altında ödem, hipersalivasyon, solunum güçlüğü, taşikardi, akut kusma, yüzde eritem ve kaşıntı, nöbet ve ataksi gibi hipersensitivite reaksiyonlarını içeren akut semptomlar gelişti. Sonuç olarak her ne kadar Rifamisin SV, insizyon hattında daha iyi iyileştirici etki sağlasa da veteriner hekimler özellikle jinekolojik operasyonlar sonrası topikal Rifamisin SV kullanımının şiddetli yan etkilerine karşı dikkatli olmalıdırlar.

Postmastectomy Life-threatening Hypersensitivity Reactions Induced by Rifamycin SV in Companion Animals: Evaluation of 7 Cases

Drug-induced hypersensitivity and adverse symptoms related to the high mortality remain as a major problem for veterinary practitioners. Although application of Rifamycin SV without intradermal susceptibility tests have been commonly used in wound management in veterinary medicine, there is no literature about this subject. In cases presented here, neoplastic masses on the mammary glands of queens (n=3) and bitches (n=4) were removed by mastectomy. Subcutaneous Rifamycin SV was performed intra- and post-operatively. After the multiple subcutaneous usage of Rifamycin SV, acute symptoms including hypersensitivity reactions such as facial and sublingual swelling, hypersalivation, respiratory distress, tachycardia, acute vomiting, erythema and itchiness around the face, seizures and ataxia developed. In conclusion, although Rifamycin SV provides better healing effects on incision line, veterinary practitioners should consider the serious side effects of subcutaneous Rifamycin SV usage after gynaecological surgeries in companion animals.

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