Altı yaşındaki çocukta Listeria menenjiti
Listeria monocytogenes sağlıklı çocuklarda nadiren menenjite neden olur. Kliniğimize baş ağrısı ve ateş yüksekliği ile başvuran 6 yaşındaki erkek olgunun daha önceden tamamen sağlıklı olduğu öğrenilmiştir. Meningiyal irritasyon bulguları pozitif olan olgunun beyin omurilik sıvısında (BOS) 1950 lö'kosit/mm3 (% 90 polimorf nüveli lökosit), glukoz 30 mg/dl (eş zamanlı kan glukozu 100 mg/dl), protein 70 mg/dl (15-45 mg/dl) olarak saptanmıştır. Olguya menenjit tanısıyla sefotaksim (200 mglkglgün) başlanmıştır. BOS kültüründe L.monocytogenes üremiş, tedavi ampisilin (300 mglkglgün) olarak değiştirilmiştir. Olgunun immünolojik tetkikleri normal bulunmuştur. Tamamen iyileşen olgu yatışının 4. haftasında taburcu edilmiştir. Bu olgu Listeria menenjitinin nadir görülmesi nedeniyle sunulmuştur.
Listeria meningitis in a six year old child
Listeria monocytogenes may rarely cause meningitis in healthy children. A six year old boy was admitted to our clinic with history of high fever and headache. He was healthy before admission. Physical examination showed positive meningial irritation signs. Lumbar puncture was performed and the CSF showed a white blood cell count of 1950 cells/mm3 with 90 % polymorphonuclear leukocytes, glucose level of 30 mg/dl, protein level of 70 mg/dl. Empirical treatment with cefotaxime (200 jiglkglday) was begun for meningitis. Since Listeria monocytogenes was isolated from CSF culture, empirical treatment with cefotaxime was changed to ampicillin (300 mglkgl day). Immunological tests were normal. The patient was discharged 4 weeks after hospitalization, having completely recovered. We report this case of Listeria meningitis because it is seen extremely rare.
___
- 1. Aouaj Y, Spanjaard L, van Leeuwen N, Dankert J: Listeria monocytogenes meningitis: serotype distribution and patient characteristics in The Netherlands, 1976-95, Epidemiol Infect 2002; 128(3):405-9.
- 2. Baltimore RS: Listeria monocytogenes, "Feigin RD, Cherry JD (eds): Textbook of Pediatric Infectious Diseases, 17.baskı" kitabında s. 890-2, WB Saunders Company, Philedelphia (2000).
- 3. Economou M, Karyda S. Kansouzıdou A, Kavaliotis J: Listeria meningitis in children: Report of two cases. Infection 2000:28:121-3.
- 4. Gemiglorgis K: Listeriosis and foods, Microbiol Ann 1991;7:267-81.
- 5. Jones EM, MaeGowan AP: Antimicrobial chemotherapy of human infection due to Listeria monocytogenes, Eur J Clin Microbiol Infect Dis 1995;14:165-75.
- 6. Kessler SL. Dajani AS: Listeria meningitis in infants and children, Pediatr Infect Dis 1990;9:61-3.
- 7. Lalloo UG, Coovadia YM. Adhikari M, Poyiadji O: Listeria monocytogenes meningitis at King Edward VIII Hospital. Durban. A 10-year experience, 1981-1990, S Afr.I Med 1992;81:187-9.
- 8. Mascola L. Sorvillo F, Lashley N, Steinberg E: Fetal meningitis in an immunocompromised infant: therapeutic implications, J Infect 1991 ;23; 287-91.
- 9. Tim MW. Jackson MA. Shannon K, Cohen B. McCracken G Jr: Non-neonatal infection due to Listeria monocytogenes. Pediatr Infect Dis J 1984:3:213-7.