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Ağız mikroflorasının genel sağlığa etkisi

Ağız mikroflorası son derece karmaşık ve eşsizdir. Yeni sekanslama teknolojisine göre >19,000 Şlotip barındırmaktadır. Bunların çoğu kommensal türlerdir ve karmaşık biyofilmler oluştururlar. Son derece dinamiktirler ve çok çeşitli çevrelere adapte olabilirler. Çevresel değişikliklere yanıt olarak eksprese ettikleri gen profilini değiştirerek patojen hale gelebilirler. Ağızın hem infeksiyon hem inflamasyona ve dolayısıyla genel sağlık ve iyilik haline katkısı çok önemlidir. Periodontitis bir bakteri infeksiyonu olarak başlayan, lokal, kronik inflamatuvar hastalıktır. Periodontitisin sistemik inflamatuvar yanıtı artırdığı ve ateroskleroz ve kardiovasküler hastalıkların olası bir risk faktörü olduğu konusunda son on yıldır kanıtlar artmıştır. Ağız sağlığı ve genel sağlık ilişkisi konusunda hem kişisel hem toplumsal düzeyde farkındalık artırılması yaşamsaldır.

The effect of oral microbiota on general health

The oral microflora is extremely diverse and unique. According to new sequencing technology, it harbors >19,000 phylotypes. They are mostly commensal species and form mixed biofilms. Their behavior can be very dynamic, adapting to a wide range of environments. They can become pathogenic by changing profiles of expressed genes in responses to environmental changes. The mouth is a significant contributor to both the total burden of infection and the total burden of inflammation and, hence, to overall health and well-being. Periodontitis is a bacterially induced, localized, chronic inflammatory disease. Periodontitis has been widely reported to be associated with an increase in the systemic inflammatory response, and has emerged as a possible risk factor for atherosclerosis and cardiovascular diseases over the last decade. It is vital in raising the awareness of oral health and general health issues at both individual and community levels.

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