Risk Faktör/erine Göre Amniyosentez Sonuçları: İleri Anne Yaşı Olan 1026 Kadının Sonucu
Aim: To compare amniocentesis results of women above age of 35 according to their risk factors (maternalage alone vs maternal age and biochemical risk)Method: This was retrospective cohort study including population of pregnant women who underwentamniocentesis between years 2006 and 2014. Women were grouped into two according to their risk factor(age alone vs age and biochemical risk). Abnormal amniocentesis results were compared among groups.Results: 702 women with only maternal age risk and 324 women with combined age and biochemical riskwere included in study (1026 in total). Mean age of the study population was 38,1 112,66. Biochemical riskgroup had 27 fetuses (8,3%) with Trisomy 21 while advanced age only risk group had 18 fetuses (2,5%)diagnosed with Trisomy 21. When added to age factor, biochemical factors increased detection of Trisomy21 significantly (Odds ratio 3,56
Amniocentesis Results According to Risk Factors: A Result of 1026 Women With Advanced Maternal Age
Aim: To compare amniocentesis results of women above age of 35 according to their risk factors (maternalage alone vs maternal age and biochemical risk)Method: This was retrospective cohort study including population of pregnant women who underwentamniocentesis between years 2006 and 2014. Women were grouped into two according to their risk factor(age alone vs age and biochemical risk). Abnormal amniocentesis results were compared among groups.Results: 702 women with only maternal age risk and 324 women with combined age and biochemical riskwere included in study (1026 in total). Mean age of the study population was 38,1 112,66. Biochemical riskgroup had 27 fetuses (8,3%) with Trisomy 21 while advanced age only risk group had 18 fetuses (2,5%)diagnosed with Trisomy 21. When added to age factor, biochemical factors increased detection of Trisomy21 significantly (Odds ratio 3,56
___
- 1. Goddijn M, Joosten JH, Knegt AC, et al. Clinical relevance of diagnosing structural chromosome abnormalities in couples with repeated miscarriage. Hum Reprod. 2004;19:1013-1017.
- 2. Balkan M, Akbas H, Kalkanli S, et al. Evaluation of clinical and cytogenetic findings on 1,068 second-trimester amniocenteses in Southeast Turkey. Clin Exp Obstet Gynecol. 2011;38:364-368.
- 3. Karaoøuz MY, Bal F, Yakut T, et al. Cytogenetic results of amniocentesis materials: incidence of abnormal karyotypes in the Turkish collaborative study. Genet Couns. 2006;17:219-230.
- 4. Bottalico JN, Chen X, Tartaglia M, et al. Second-trimester genetic sonogram for detection of fetal chromosomal abnormalities in a community-based antenatal testing unit.Ultrasound Obstet Gynecol. 2009;33:161-168
- 5. Qi QW, Jiang YL, Zhou XY, et al. Genetic counseling, prenatal screening and diagnosis of Down syndrome in the second trimester in women of advanced maternal age: a prospective study. Chin Med J. 2013;126(11):2007-2010.
- 6. Han SH, An JW, Jeong GY et al. Clinical and cytogenetic findings on 31,615 midtrimester amniocenteses. Korean J Lab Med. 2008; 28: 378-385.
- 7. Chang YH, Chen PY, Li TY, et al. Discrepancy of cytogenetic analysis in Western and Eastern Taiwan. Pediatric Neonatology 2013;54:161-165.
- 8. Ocak Z, Ozlü T, Yazcog?lu HF, Ozyurt O, Aygün M. Clinical and cytogenetic results of a large series of amniocentesis cases from Turkey: report of 6124 cases. Journal of Obstetrics and Gynaecology Research 2013;40:139-146.
- 9. Danisman N, Kahyaoglu S, Celen S, et al. A retrospective analysis of amniocenteses performed for advanced maternal age and various other indications in Turkish women. Journal of Maternal-Fetal Neonatal Medicine 2013; 26:242-245.
- 10. Kohatsu M, Carvalho MH, Vieira Francisco RP, Amorim Filho AG, Zugaib M. Analysis of fetal and maternal results from fetal genetic invasive procedures: an exploratory study at a University Hospital. Revista da Associacao Medica Brasileira 2012;58:703-708.
- 11. Berkowitz RL, Roberts J, Minkoff H. Challenging the strategy of maternal agebased prenatal genetic counseling. Journal of the American Medical Association 2006;295:1446-1448.
- 12. ACOG Practice Bulletin No. 77: Screening for fetal chromosomal abnormalities. Obstet Gynecol 2007;109: 217- 227.
- 13. Bornstein E, Lenchner E, Donnenfeld A, et al. Advanced maternal age as a sole indication for genetic amniocentesis; risk benefit analysis based on a large database reflecting the current common practice. Journal of Perinatal Medicine 2009; 37:99-102.